Protein Alignment GK and CG1271

DIOPT Version :10

• Sequence 1: XP_011543793.1
• Gene: GK / 2710
• HGNCID: 4289
• Length: 587
• Species: Homo sapiens
• Sequence 2: NP_647763.1
• Gene: CG1271 / 38364
• FlyBaseID: FBgn0035392
• Length: 556
• Species: Drosophila melanogaster
• Alignment Length: 578
• Identity: 153/578 - (26%)
• Similarity: 248/578 - (42%)
• Gaps: 102/578 - (17%)

Human    15 AVDQGTSSTRFLVFNSK---------TAELLSHHQVEIKQEFPREGWVEQDPKEILHSVYECIEK 70
            |:|.||:..|..|.:.:         ..|||:          |:.|:.|.:|:.:...:...|.:
  Fly    35 ALDVGTTCVRSFVLDEQCEVRGSAVDAVELLN----------PQPGYFEIEPESLWRKIVGVITQ 89

Human    71 TCEKLGQLNIDISNIKAIGVSNQRETTVVWDKITGEPLYNAVAAPVSPGPSVPVAVVPSGSSVPA 135
            .. |..||.  ..:|..:.:|.||.|.:.||..:||..:|.:
  Fly    90 AV-KNAQLT--PPDITCLTISTQRCTFLTWDHRSGEYYHNFI----------------------- 128

Human   136 PGTSSVWLDLRTQSTVESLSKRIPGNNNFVKSK------------------TGLPLSTYFSAVKL 182
                 .|.|||....|:.      .|.::.||.                  .|..|......|..
  Fly   129 -----TWKDLRADELVDQ------WNASWTKSSMNWFSYALFLLTRQSRFLAGSVLQLMNGQVTP 182

Human   183 RWLLD--NVRKVQKAVEEKRALFGTIDSWLIWSLTGGVNGG---VHCTDVTNASRTMLFNIHSLE 242
            |.|.:  |.:|:::|:.:|:|....:|||::..|..|.:..   .|.||||:::.|.|::..:|.
  Fly   183 RLLFEIMNNKKLKQALMQKKARVELLDSWILHKLRTGSSRDKDVEHITDVTSSTATGLYDPFTLS 247

Human   243 WDKQLCEFFGIPMEILPNVRSSSEIYGLMKISHSVKAG---ALEGVPISGCLGDQSAALVGQMCF 304
            |...:...|||..:|||.|..:.  |......|....|   |...:||:..|.||:||:.|..||
  Fly   248 WSPLISWLFGINSKILPRVVDNG--YKGFGHVHPTAFGPDWANTEIPIAASLSDQTAAIWGSQCF 310

Human   305 QIGQAKNTYGTGCFLLCNTGHKCVFSDHGLLTTVAY---KLGRDKPVYYALEGSVAIAGAVIRWL 366
            |....|.|.|||.||...||.:|.....|:...||:   |..|.:...|.:||:....|.|:.|.
  Fly   311 QKNDVKVTMGTGAFLNLVTGDRCQAVISGMYPLVAWQFKKPTRQQGAVYCIEGASHDFGTVVTWA 375

Human   367 RDNLGIIKTSEEIEKLAKEVGTSYGCYFVPAFSGLYAPYWE-PSARGIICGLTQFTNKCHIAFAA 430
            : :..:..:......:|:.|..:...:|:||||||..|..: .||.|.| |||..|.|.|:..|.
  Fly   376 Q-SCELFDSPANTSDIAQSVPDTNDVFFMPAFSGLGPPVNDYRSASGFI-GLTPSTTKAHMVRAL 438

Human   431 LEAVCFQTREILDAMNRDCGIPLSHLQVDGGMTSNKILMQLQADILYIPVVKPSMPETTALGAAM 495
            ||::.|:..::::|..::....|..::||||::.|..:.|..||:..:.|.:....|::.:||..
  Fly   439 LESIVFRLVQLIEAAEKETSQKLHMIRVDGGVSRNDFVCQFLADLSRLRVERADNAESSIMGATF 503

Human   496 AAGAAEGVGVWSLEPEDLSAVTMER-----FEPQINAEES-EIRYSTWKKAVMKSMGW 547
            .||.  .:|:|    .|::.:...|     |||:....|: ..|...|.:.:.:...|
  Fly   504 MAGI--NLGIW----RDVNDLKRFRKVARVFEPRPKEYETIANRMDKWSRTIARFSDW 555

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GK	XP_011543793.1	ASKHA_NBD_FGGY_GK1-3-like	11..544	CDD:466802	152/573 (27%)
CG1271	NP_647763.1	ASKHA_NBD_FGGY_GK5-like	32..549	CDD:466803	152/570 (27%)