Protein Alignment GK and CG8298

DIOPT Version :10

• Sequence 1: XP_011543793.1
• Gene: GK / 2710
• HGNCID: 4289
• Length: 587
• Species: Homo sapiens
• Sequence 2: NP_610718.1
• Gene: CG8298 / 36282
• FlyBaseID: FBgn0033673
• Length: 596
• Species: Drosophila melanogaster
• Alignment Length: 636
• Identity: 230/636 - (36%)
• Similarity: 338/636 - (53%)
• Gaps: 91/636 - (14%)

Human     1 MAASKKAVLGPLVGAVDQGTSSTRFLVFNSKTAELLSHHQVEIKQEFPREGWVEQDPKEILHSVY 65
            |:..:....|.|:|.....::..|||::::|.||:|::|:::::|...:.||:|.||.||..:..
  Fly     1 MSNGRYGRFGALIGVACVSSTHCRFLIYSTKNAEVLAYHELKLRQIVHQAGWMEYDPSEIWKNTQ 65

Human    66 ECIEKTCEKLGQLNIDISNIKAIGVSNQRETTVVWDKITGEPLYNAVAAPVSPGPSVPVAVVPSG 130
            ||||...:.|..|.|:..:|.|||:.|||.|:|:|:..||:||:||:.
  Fly    66 ECIETAYKNLVILEINPRDIIAIGIVNQRGTSVLWNLETGQPLHNAIG----------------- 113

Human   131 SSVPAPGTSSVWLDLRTQSTVESLSKRIPGNNNFVKSKTGLPLSTYFSAVKLRWLLDNVRKVQKA 195
                       |.|.|:...:::|...:..|.::|:.::|||||:.|||:|:|||:|:|..|..|
  Fly   114 -----------WSDCRSTPILKTLLHNVRHNVDYVRYRSGLPLSSCFSALKIRWLMDHVPAVATA 167

Human   196 VEEKRALFGTIDSWLIWSLTGGVNGGVHCTDVTNASRTMLFNIHSLEWDKQLCEFFGIPMEILPN 260
            :||.:.||||:||||:|:|||||..|||.||:|||..|.|.|:.:.:||.:||:||.:|:.|||.
  Fly   168 IEENKCLFGTLDSWLLWNLTGGVEMGVHSTDITNAHYTSLMNVSTEQWDPKLCQFFRLPLNILPR 232

Human   261 VRSSSEIYGLMKISHSVKAGALEGVPISGCLGDQSAALVGQMCFQIGQAKNTYGTGCFLLCNTGH 325
            :||:|||:|.      |..|.|.|.||:..:|:|.|:|:||:|.:.||...|....||:|.|||.
  Fly   233 IRSNSEIFGY------VLEGPLHGTPIAAMMGEQPASLLGQLCVKAGQNVCTLDDSCFVLLNTGR 291

Human   326 KCVFSDHGLLTTVAYKLGRDKPVYYALEGSVAIAGAVIRWLRDNLGI---IKTSEE-IEKLAKEV 386
            :.:.|.:||:|.:|:|||......|.|||:::.||:.:.||||.|.|   |.:::. :|.|...:
  Fly   292 EKLDSANGLITGIAHKLGEKAATNYTLEGAISNAGSTVTWLRDKLQINTEINSNDNVVESLNTFI 356

Human   387 G----TSYGC------------------YFVPAFSGLYAPYWEPSARGIICGLTQFTNKCHIAFA 429
            |    .|..|                  .|||||.|:|||||...|||||.|||..|...:|..|
  Fly   357 GENSMISSSCSSSMLNAECGLAAKRSEITFVPAFHGMYAPYWRHDARGIILGLTSQTTAENITQA 421

Human   430 ALEAVCFQTREILDAMNRDCG-------IPLSHLQVDGGMTSNKILMQLQADILYIPVVKPSMPE 487
            |.||..||..|:|.|..||..       .|:  |...|....|..|:|..|||:...:.:|....
  Fly   422 AYEATGFQIFEVLQAFKRDTPNWDRSSMQPV--LTFGGDYAENLHLVQFIADIIGYMLERPQTTS 484

Human   488 TTALGAAMAAGAAEGVGVWSLEPEDLSAVTM-----ERFEPQINAEESEIRYSTWKKAVMKSMGW 547
            ...||..:.||..  :.|.|||    .||.|     :.|.|.......|:.|..|..||.|.:.|
  Fly   485 PAGLGVMITAGVT--MKVVSLE----HAVKMYTPPTDVFSPTTTKNRRELLYKRWAYAVKKCLHW 543

Human   548 VTTQSPESG---------DPS--IFCSLPLGFFIVSSMVMLIGARYISGIP 587
            ...::.|:.         ||:  :..|:|...|:.:|..|:|.|.|:...|
  Fly   544 NNYETYEADIELFAQRELDPNLPVRRSVPGSIFLTTSFAMIILANYLKSNP 594

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GK	XP_011543793.1	ASKHA_NBD_FGGY_GK1-3-like	11..544	CDD:466802	214/570 (38%)
CG8298	NP_610718.1	ASKHA_ATPase-like	19..540	CDD:483947	212/562 (38%)