DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GK and Rpt6

DIOPT Version :9

Sequence 1:	XP_011543793.1	Gene:	GK / 2710	HGNCID:	4289	Length:	587	Species:	Homo sapiens
Sequence 2:	NP_608447.1	Gene:	Rpt6 / 33105	FlyBaseID:	FBgn0020369	Length:	405	Species:	Drosophila melanogaster

Alignment Length:	147	Identity:	29/147 - (19%)
Similarity:	58/147 - (39%)	Gaps:	24/147 - (16%)

- Green bases have known domain annotations that are detailed below.

Human   361 AVIRWLRDNLGIIKTSEEIEKLAKEVGTSYGCYFVPAFSGLYAPYWEPSARGII-----CGLTQF 420
            |.:|.||:.|          :|.:|.|:..|....|...........|..:.::     ..:...
  Fly    53 AKVRMLREEL----------QLLQEQGSYVGEVVKPMDKKKVLVKVHPEGKFVVDLDKNIDINDV 107

Human   421 TNKCHIAFA----ALEAVCFQTREILDAMNRDCGIPLSHLQVDGGMTSNKILMQLQADILYIPVV 481
            |..|.:|..    .|..:.....:.|.::.....:|.|..::.||:  :|.:.::: :::.:||.
  Fly   108 TPNCRVALRNESYTLHKILPNKVDPLVSLMMVEKVPDSTYEMVGGL--DKQIKEIK-EVIELPVK 169

Human   482 KPSMPETTALGAAMAAG 498
            .|.:.:  |||.|...|
  Fly   170 HPELFD--ALGIAQPKG 184

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GK	XP_011543793.1	FGGY_GK1-3_metazoa	11..547	CDD:212664	29/147 (20%)
Rpt6	NP_608447.1	RPT1	17..403	CDD:224143	29/147 (20%)
		SlyX	<27..>69	CDD:294687	7/25 (28%)
		AAA_16	152..>205	CDD:289934	10/38 (26%)
		AAA	185..317	CDD:278434	29/147 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0554
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900