Protein Alignment AMPD2 and Adgf-B

DIOPT Version :10

• Sequence 1: NP_004028.4
• Gene: AMPD2 / 271
• HGNCID: 469
• Length: 825
• Species: Homo sapiens
• Sequence 2: NP_649006.2
• Gene: Adgf-B / 39975
• FlyBaseID: FBgn0036751
• Length: 520
• Species: Drosophila melanogaster
• Alignment Length: 527
• Identity: 109/527 - (20%)
• Similarity: 172/527 - (32%)
• Gaps: 203/527 - (38%)

Human   342 KELAAQKKVPHRDFYNIRK-----VDTHIHASSCMNQKHLL----------------------RF 379
            |.||..:|.|   .:|:.|     ...|.|.::..:..:|:                      ||
  Fly    99 KTLAEVQKSP---IFNLIKGMPKGGALHAHDTALCSTDYLISLTYRKNLWICTAEEGCKAIAFRF 160

Human   380 IKRAMKRHLEEIVHVEQGREQTLRE-VFESM----------NLTAYDLSVDTLDVHADRNTFHRF 433
            .|             |:.:|:.::| ::|.|          |:|.|         ...|.:.:.|
  Fly   161 SK-------------EEPKEKPVKESIWEPMEEFRERRGEENVTKY---------LTRRFSMYPF 203

Human   434 DKFNAKYNPIGESVLREIFIKTDN-----RVSGKYFAHIIKEVMSDLEESKYQNAELRLSIYGRS 493
            .||.:  |....:....|||..|.     .:..:|:.:.:||    ..|...|..|||..:
  Fly   204 SKFIS--NNQAWAHFMGIFILLDGLLCHAPIWAEYYYNALKE----FAEDGVQYLELRSLL---- 258

Human   494 RDEWDKLARWAVMHRVHSPNVRWLVQVPRLF----DVYRTKGQLANFQEMLEN------------ 542
                                       |.|:    |:...:..:|.:...||.
  Fly   259 ---------------------------PPLYCIDGDMLTIRDTVAIYNSELERFRADHPDFIGSK 296

Human   543 -IFLPL--FEATV---HPASHPELHL-FLEHVDGFDSVDDE--SKPENHVFNLESPLPEAWVEED 598
             |:.||  .|.:|   :..:..||:. |...:.|||.|..|  .:|   :.:...||
  Fly   297 LIYAPLRGVEPSVVEQYVKTAVELNKEFPNFMVGFDLVGQEELGRP---LIDFVEPL-------- 350

Human   599 NPPYAYYLYYTFANMAMLNHLRRQRGFHTFVLRPHCGE----AGPI-HHLVSAFML-AENISHGL 657
                          :.|..|:    .|:.     |.||    ..|| .:||.|.:| .:.|.||.
  Fly   351 --------------LKMPEHI----NFYF-----HAGETNWFGSPIDENLVDAILLGTKRIGHGY 392

Human   658 LLRKAPVLQYLYYLAQIGIAMSPLSNNSLFL--SYHRNPLPEYLSRGLMVSLSTDDPLQFHFTKE 720
            .:.|.|::..|..|..|.|.:.|:||..|.|  .|..:|....|:..:.:.:|:|||..:|..
  Fly   393 AITKHPMMMRLAKLLGIAIEVCPVSNQVLQLGVDYRNHPAALLLAANVPIVISSDDPSFWHCA-- 455

Human   721 PLMEEYSIA---TQVWKLSSCDMCELARNSVLMSGFSHKVKSHWLGPNYTKEGPEGNDIRRTNVP 782
            ||..::..|   ....|.....:..||.||:..|....:.|
  Fly   456 PLSHDFYFAFLGIAPMKADLRFLKSLAINSIRYSALVGEEK------------------------ 496

Human   783 DIRVGYR 789
              |||||
  Fly   497 --RVGYR 501

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AMPD2	NP_004028.4	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..49
		AMP_deaminase	163..806	CDD:437158	109/527 (21%)
Adgf-B	NP_649006.2	adm_rel	56..515	CDD:273620	109/527 (21%)