Protein Alignment AMPD2 and Adgf-E

DIOPT Version :10

• Sequence 1: NP_004028.4
• Gene: AMPD2 / 271
• HGNCID: 469
• Length: 825
• Species: Homo sapiens
• Sequence 2: NP_610977.1
• Gene: Adgf-E / 36627
• FlyBaseID: FBgn0033952
• Length: 539
• Species: Drosophila melanogaster
• Alignment Length: 605
• Identity: 120/605 - (19%)
• Similarity: 197/605 - (32%)
• Gaps: 194/605 - (32%)

Human   235 TPVSADAPVHPP----ALEQHPYEHCEPSTMPGDLGLGLRMVRGVVHVYTRREPDEHCSEVELPY 295
            ||.:|....|.|    .||.....:...|| |.|    .|::|.:.:.:.|.....:..::.||.
  Fly    19 TPTAAQWIHHNPEKMTLLEMLGTTNLRKST-PKD----YRILREIFNSFERYSGVGNDIQLTLPE 78

Human   296 PDLQEFVADVNVLMALIINGPIKSFCYRRLQYLS-----SKFQ--MHV--------------LLN 339
            ....|.:                 .|.::.:|..     |||.  .|:              :|.
  Fly    79 RAANELI-----------------MCEKKREYEKGIMDPSKFAPGHHIFQVLTKVKKSPLFQILR 126

Human   340 EMKELAAQK-------------KVPHRDFYNIRKVDTHIHASSCMNQKHLLRFIKRAMKRHLEEI 391
            .|.:.||.|             ::.:||  |:....|.   :.|..::  .||.|...|.
  Fly   127 RMPKGAALKAHDTSMCSSRVVIEITYRD--NLWVCTTQ---NGCRVEE--FRFAKDKPKD----- 179

Human   392 VHVEQGR------------EQTLREVFESMNLTAYDLSVDTLDVHADRNTFHRFDKFNA--KYNP 442
            |..|.|.            |:.||:..: |..:.|.|:..|.:.||.|:....|...:.  :|.|
  Fly   180 VSFENGEWQPMEKLRELRGEENLRKYLQ-MRFSMYPLASFTTNAHAWRHMMGIFGLLDGLLQYAP 243

Human   443 IGESVLREIFIKTDNRVSGKYFAHIIKEVMSD----------------LEESKYQNAELRLSIYG 491
                            |.|.|:.:.:||..:|                |:.|:....| .:.||.
  Fly   244 ----------------VWGDYYYNALKEFYADGVQYLEVRSVLPQLYSLDGSRMPKRE-TVQIYK 291

Human   492 RSRDEWDKLARWAVMHRVHSPNVRWLVQVPRLFDVYRTKGQLANFQEMLENIFLPLFEATVHPAS 556
                  |.|.|:...|             |...|.......:.:.|..|...::.  |.|
  Fly   292 ------DTLERFKKEH-------------PGFIDSKLIYAPIRHVQPELVGEYIK--ECT----- 330

Human   557 HPELHL-FLEHVDGFDSVDDESKPENHVFNLESPLPEAWVEEDNPPYAYYLYYTFANMAMLNHLR 620
              ||:. |...|.|||.|..|        ::..||.....|....|...:.|:
  Fly   331 --ELNKEFPSFVVGFDLVGQE--------DVGHPLSNFAAELLKLPDHIHFYF------------ 373

Human   621 RQRGFHTFVLRPHCGEAG-----PIHHLVSAFML-AENISHGLLLRKAPVLQYLYYLAQIGIAMS 679
                        |.|:..     ...:|:.|.:| .:.|.||..:.|.|||..|.....|.:.:.
  Fly   374 ------------HAGQTNWYGSHVDQNLLDAIVLGTKRIGHGYTITKHPVLMRLAKYLNIALEVC 426

Human   680 PLSNNSLFL--SYHRNPLPEYLSRGLMVSLSTDDPLQFHFTKEPLMEEYSIATQVWKLSSCDMCE 742
            |:||..|.|  .|..:|....::..:.:.:::..|  ..:...||..::.:|.......:.|:..
  Fly   427 PVSNQVLQLGSDYRSHPAATLIAENVPMVIASGSP--GFWRAAPLSHDFYMAFLGIAPMNADLKF 489

Human   743 L---ARNSVLMSGFSHKVKS 759
            |   |:||:..|....:.|:
  Fly   490 LKRTAKNSIKYSSLKDEAKA 509

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AMPD2	NP_004028.4	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..49
		AMP_deaminase	163..806	CDD:437158	120/605 (20%)
Adgf-E	NP_610977.1	adm_rel	52..527	CDD:273620	109/567 (19%)