Protein Alignment AMPD2 and AMPdeam

DIOPT Version :10

• Sequence 1: NP_004028.4
• Gene: AMPD2 / 271
• HGNCID: 469
• Length: 825
• Species: Homo sapiens
• Sequence 2: NP_001285233.1
• Gene: AMPdeam / 32352
• FlyBaseID: FBgn0052626
• Length: 798
• Species: Drosophila melanogaster
• Alignment Length: 795
• Identity: 455/795 - (57%)
• Similarity: 567/795 - (71%)
• Gaps: 50/795 - (6%)

Human    26 STAAPEARGGLGA----PPLQSARSLPGP-------APC-LKHFPLDLRTSMDGKCKEIAEELFT 78
            |.||..|.|.||:    ..|.:..|:..|       |.| |...|:|.:...|   .|:..|:
  Fly    31 SHAATNAAGPLGSKASGKSLNACTSMSMPQKPSSLRATCDLADSPVDEKAEAD---VEVTNEI-- 90

Human    79 RSLAESELRSAPYEFPEESPIEQLEERRQRLERQISQDVKLEPDILLRAKQDFLKTDSDSDLQLY 143
                     |||||.| :.||||:|::.| ::|.:::.....|..:..|.  .|.|:.:|
  Fly    91 ---------SAPYEVP-QFPIEQIEKKLQ-IQRHLNEKQATGPRPVATAA--VLATNRES----- 137

Human   144 KEQGEGQGDRSLRERDVLEREFQRVTISGEEKCGVPFTDLLDAAKSVVRALFIREKYMALSLQSF 208
            ....||:......||:..:..||||:||||:..|||..||..|:..::.||.:|..|||:|.|||
  Fly   138 SSSTEGRESAVTMERNDADINFQRVSISGEDTSGVPLEDLERASTLLIEALRLRSHYMAMSDQSF 202

Human   209 CPTTRRYLQQLAEKPLETRTYEQGPDTPVSADAPVHPPALEQHPYEHCEPSTM--PGDLGLGLRM 271
            ..||.|:|:.:..|       ::..:.||...:.||   |...|.:...|..:  |.|....::.
  Fly   203 PSTTARFLKTVKLK-------DRINNLPVKEVSDVH---LRHSPMKITNPWNVEFPNDEDFKIKP 257

Human   272 VRGVVHVYTRREPDEHCSEVELPYPDLQEFVADVNVLMALIINGPIKSFCYRRLQYLSSKFQMHV 336
            :.||.|:|   |.|:..||::..|||:.:||.|:.|:..:|.:||:||||||||.|||||:||||
  Fly   258 LNGVFHIY---ENDDESSEIKYEYPDMSQFVNDMQVMCNMIADGPLKSFCYRRLCYLSSKYQMHV 319

Human   337 LLNEMKELAAQKKVPHRDFYNIRKVDTHIHASSCMNQKHLLRFIKRAMKRHLEEIVHVEQGREQT 401
            ||||::||||||.||||||||.|||||||||:|||||||||||||:.:|.:..|:|.|..|::.|
  Fly   320 LLNELRELAAQKAVPHRDFYNTRKVDTHIHAASCMNQKHLLRFIKKTLKNNANEVVTVTNGQQMT 384

Human   402 LREVFESMNLTAYDLSVDTLDVHADRNTFHRFDKFNAKYNPIGESVLREIFIKTDNRVSGKYFAH 466
            |.:||:|||||.|||:||.|||||||||||||||||:||||||||.|||:|:||||.::|||||.
  Fly   385 LAQVFQSMNLTTYDLTVDMLDVHADRNTFHRFDKFNSKYNPIGESRLREVFLKTDNYLNGKYFAQ 449

Human   467 IIKEVMSDLEESKYQNAELRLSIYGRSRDEWDKLARWAVMHRVHSPNVRWLVQVPRLFDVYRTKG 531
            |||||..||||||||||||||||||:|.|||.|||:||:.:.|:|.|:|||:|:|||||::::..
  Fly   450 IIKEVAFDLEESKYQNAELRLSIYGKSPDEWYKLAKWAIDNDVYSSNIRWLIQIPRLFDIFKSNK 514

Human   532 QLANFQEMLENIFLPLFEATVHPASHPELHLFLEHVDGFDSVDDESKPENHVFNLESPLPEAWVE 596
            .:.:|||:|.||||||||||..|:.|||||.||::|.|||||||||||||.:|:.:.|.||.|..
  Fly   515 MMKSFQEILNNIFLPLFEATARPSKHPELHRFLQYVIGFDSVDDESKPENPLFDNDVPRPEEWTY 579

Human   597 EDNPPYAYYLYYTFANMAMLNHLRRQRGFHTFVLRPHCGEAGPIHHLVSAFMLAENISHGLLLRK 661
            |:|||||||:||.:|||.:||..|:.|..:|||||||||||||:.|||..|::||||||||||||
  Fly   580 EENPPYAYYIYYMYANMTVLNKFRQSRNMNTFVLRPHCGEAGPVQHLVCGFLMAENISHGLLLRK 644

Human   662 APVLQYLYYLAQIGIAMSPLSNNSLFLSYHRNPLPEYLSRGLMVSLSTDDPLQFHFTKEPLMEEY 726
            .|||||||||.||||||||||||||||:||||||||||:|||::|||||||||||||||||||||
  Fly   645 VPVLQYLYYLTQIGIAMSPLSNNSLFLNYHRNPLPEYLARGLIISLSTDDPLQFHFTKEPLMEEY 709

Human   727 SIATQVWKLSSCDMCELARNSVLMSGFSHKVKSHWLGPNYTKEGPEGNDIRRTNVPDIRVGYRYE 791
            |||.||||||||||||||||||:||||.|.:|..||||.|.::|..||||.|||||:|||.||||
  Fly   710 SIAAQVWKLSSCDMCELARNSVMMSGFPHAIKQQWLGPIYYEDGIMGNDITRTNVPEIRVAYRYE 774

Human   792 TLCQELALITQAVQS 806
            ||..||:.|.:..|:
  Fly   775 TLLDELSNIFKVNQT 789

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AMPD2	NP_004028.4	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..49		9/26 (35%)
		AMP_deaminase	163..806	CDD:437158	414/644 (64%)
AMPdeam	NP_001285233.1	AMPD	284..780	CDD:238644	362/495 (73%)