Protein Alignment FOXP1 and FoxP

DIOPT Version :10

• Sequence 1: NP_001231739.1
• Gene: FOXP1 / 27086
• HGNCID: 3823
• Length: 693
• Species: Homo sapiens
• Sequence 2: NP_001247011.1
• Gene: FoxP / 41182
• FlyBaseID: FBgn0262477
• Length: 520
• Species: Drosophila melanogaster
• Alignment Length: 475
• Identity: 181/475 - (38%)
• Similarity: 242/475 - (50%)
• Gaps: 113/475 - (23%)

Human   245 TGNNHSSLDLTTTCVSSSAP------SKTSLIM---NPHASTNGQ-LSVHTP------------K 287
            ||..::|:...:..|..|:|      |.|:...   |||....|| :....|            :
  Fly    52 TGFLNNSITFASHVVKCSSPASSIDESSTAAQQHESNPHMHIQGQHMMAPVPDLGFYNVPEFISE 116

Human   288 RESL-----------------------SHEE---HPHSHPLYGHGVCKWPGCEAVCEDFQSFLKH 326
            :|.|                       .|:|   ..:.|||:.||:|:|||||...||..||:||
  Fly   117 QEKLMFSDAERFLRSKDNEVCNNDFSYMHDEFAMRKYYHPLFAHGICRWPGCEMDLEDITSFVKH 181

Human   327 LNSEHALDDRSTAQCRVQMQVVQQLELQLAKDKERLQAMMTHLH---------------VKSTEP 376
            ||:||.||||||||.|||||||.|||..|.|:::||||||.||:               |...|.
  Fly   182 LNTEHGLDDRSTAQARVQMQVVSQLESHLQKERDRLQAMMHHLYLSKQLLSPTKIDRKDVPGREG 246

Human   377 KAAPQPLNLVSSVTLSKSASEASPQSLPHTPTTPTAPLTPVTQGPSVITTTSMHTVGPIRRRYSD 441
            |....||.:.|.....:..:..||.:||                  ::.:|::.:   |::|..|
  Fly   247 KFCRSPLTVNSIGRPIRQTNSPSPLNLP------------------MVNSTNLCS---IKKRNHD 290

Human   442 KYNVPISSA--------------DIAQNQEFYKNAEVRPPFTYASLIRQAILESPEKQLTLNEIY 492
            |....|:..              :|.:|:||||||:|||||||||||||||::||:|||||||||
  Fly   291 KNTFSINGGLPYMLERAGLDVQQEIHRNREFYKNADVRPPFTYASLIRQAIIDSPDKQLTLNEIY 355

Human   493 NWFTRMFAYFRRNAATWKGAIRTNLSLHKCFIRVEDEFGSFWTVDDEEFKRGRHIQRGRPRKYCP 557
            |||...|.||||||||||.||||||||||||:|.||:|||||.|||.||.:.||:.|||||||.|
  Fly   356 NWFQNTFCYFRRNAATWKNAIRTNLSLHKCFVRYEDDFGSFWMVDDNEFVKRRHLSRGRPRKYEP 420

Human   558 DENFDELVAHN--PSLIKNMQSSHAYCTPLNAALQASMAENSIPLYTTASMGN----PTLGN--L 614
            ..:.:...:.|  |:......:...:||.|...     |:|.:.......:|.    |..|:  |
  Fly   421 SSSPNSCQSGNGVPTDKNPCDNCTQHCTSLPPG-----ADNPLDSNNPNDLGRIGCLPYCGSDGL 480

Human   615 ASAIRE--ELNGAMEHTNSN 632
            :.|.::  .::..|..:||:
  Fly   481 SKASKDYSNMDSGMIESNSH 500

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FOXP1	NP_001231739.1	FOXP-CC	302..369	CDD:465036	45/66 (68%)
		FH_FOX	464..545	CDD:469596	65/80 (81%)
FoxP	NP_001247011.1	FOXP-CC	157..224	CDD:465036	45/66 (68%)
		FH_FOX	327..408	CDD:469596	65/80 (81%)