Protein Alignment FOXP1 and fkh-7

DIOPT Version :10

• Sequence 1: NP_001231739.1
• Gene: FOXP1 / 27086
• HGNCID: 3823
• Length: 693
• Species: Homo sapiens
• Sequence 2: NP_001023147.1
• Gene: fkh-7 / 177340
• WormBaseID: WBGene00001439
• Length: 778
• Species: Caenorhabditis elegans
• Alignment Length: 833
• Identity: 214/833 - (25%)
• Similarity: 325/833 - (39%)
• Gaps: 258/833 - (30%)

Human    11 SNGSAIQNGSGGSNHLLECGGLREGRSNGETPAVDIGAADLAHAQQQQQQALQVARQLLLQQQQ- 74
            |:.|.:.:.:..:||||               |.|....|:.| :::::...::..::.:|.:.
 Worm    17 SSTSTVTSPTSQNNHLL---------------AEDEEQIDVVH-EEEEEDMEEMKMEIEMQSKSL 65

Human    75 QQQVSGLK-----------------------------SPKRNDK----------QPALQVPVSVA 100
            .|:.|||:                             .|..:|.          :||..:|..
 Worm    66 HQKPSGLRRSFRPLIASELRSGGIHKTSSDSNLKRLAGPSSSDSAGTSGYGYLPRPASNLPAG-- 128

Human   101 MMTPQVITPQQMQQILQQQVLSP-QQLQVLLQQQQALMLQQQQLQEFYKKQQEQLQLQLLQQQHA 164
                          |..:..:.| |.:|..||..|:|| ....:.....|      |.:.:.||.
 Worm   129 --------------INHEFKIDPLQTVQQFLQMHQSLM-NSPSVPTCLSK------LLIDEDQHN 172

Human   165 GKQPKEQQQVATQQLAFQQQLLQMQQLQQ------------QH--------------LLSLQRQG 203
            .:.......|....:...:.|.:..|.|.            .|              ||:||.:
 Worm   173 HQSTTTLNNVLAPPMITSESLPRPTQAQSFANSTIGGGANTSHLPVTLDTGINDNLILLALQER- 236

Human   204 LLTIQPGQPALPLQPLAQGMIPTELQQLWKEVTSAHTAEETTGNNHSSLDLTTTCVSS------- 261
              .::|.||.     |.|......|..|     :|.|...|...:..|.| ||..:..
 Worm   237 --LMRPQQPT-----LTQSATTPSLSHL-----AAATNSSTNATSLGSAD-TTRLIQQMFLGQML 288

Human   262 --SAPSKTSLIMNPHASTNGQLSVHTPKRESLSHEEHPHSHPLYGHGVCKWPGCEAVCEDFQSFL 324
              ..|:...|     |||....|:..|.:.::........|.|:.||:|.||.|:..|:...:.:
 Worm   289 IPQLPAALDL-----ASTIQSASMSLPLQTTIPQPMSAPQHALWQHGMCAWPSCDQPCDSVMALI 348

Human   325 KHLNSEHALDDRSTAQCRVQMQVVQQLELQLAKDKERLQAMMTHLHVK----------------- 372
            .||..||...|:|..:.|.|::.|:.:|.:|:.::.|||.||.||.:|
 Worm   349 THLQHEHPPSDKSNEEMRNQIEKVESIEHKLSVERSRLQGMMQHLRMKPSPDTTTPNLVKMEAQS 413

Human   373 ------------------------STEPKAAPQP------LNLVSSVTLSKSASEASP------- 400
                                    :::|:.:|..      |::.::|..|.:|:..||
 Worm   414 PLRSPKIEGAAFSIQPAQQFQQQTTSQPQVSPTSEAASSLLSIAATVAASTAAAVTSPINQISTV 478

Human   401 ---QSLP-------HTPTTPTAPLTPVTQGP-------SVITTTSMH----TVGPIRRRYSDKYN 444
               .|:|       .|.:.|::.....:.||       |..|.||.:    :..|.|.|.|||..
 Worm   479 PSVSSMPSFLNHQLSTSSQPSSQQASGSSGPLLQRAASSASTETSPNPDSKSFVPRRSRISDKTV 543

Human   445 VPISSADIAQNQEFYKNAEVRPPFTYASLIRQAILESPEKQLTLNEIYNWFTRMFAYFRRNAATW 509
            .||:: |||:|::||:..:||||:||||||||||:||.:.||||||||.|||..|||||||||||
 Worm   544 QPIAT-DIAKNRDFYRTNDVRPPYTYASLIRQAIMESSDCQLTLNEIYTWFTETFAYFRRNAATW 607

Human   510 KGAIRTNLSLHKCFIRVEDEF-GSFWTVDDEEFKRGR----HIQRGRPRKYCPDE---------- 559
            |.|:|.||||||||.|||... |:.|||||.||.|.|    ...|.:|:...||:
 Worm   608 KNAVRHNLSLHKCFQRVEQNVKGAVWTVDDSEFYRRRPNRASATRSQPQTPLPDDISQQKLFDTS 672

Human   560 ---NFDELVAHNPSLIKNMQSSHAYCTPLNAALQASMAENSIPLYTTASMGNP-TLGNLASAIRE 620
               :|.|:...:|:.:...|..      ||..|     ::.:.|...|.:.|| .:.:.|:|...
 Worm   673 ALSSFLEMQNFDPASLTGDQFQ------LNGNL-----DSVLSLLANADVNNPLQMLSAAAAAGN 726

Human   621 ELNGAMEHTNSNESDSSPGRSPMQAVHPVHVKEEPLDPEEAEGPLSLVTTANH 673
            ...|.:|....|                 :||||.:|..|.... .|:..|.|
 Worm   727 HSGGILEGQLLN-----------------NVKEEMMDVSEPHNG-HLLRVARH 761

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FOXP1	NP_001231739.1	FOXP-CC	302..369	CDD:465036	24/66 (36%)
		FH_FOX	464..545	CDD:469596	61/81 (75%)
fkh-7	NP_001023147.1	FOXP-CC	326..393	CDD:465036	24/66 (36%)
		FH_FOXP2	562..644	CDD:410839	61/81 (75%)