DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DAPP1 and YOR343W-B

DIOPT Version :9

Sequence 1:	NP_055210.2	Gene:	DAPP1 / 27071	HGNCID:	16500	Length:	280	Species:	Homo sapiens
Sequence 2:	NP_620389.3	Gene:	YOR343W-B / 854523	SGDID:	S000007356	Length:	1770	Species:	Saccharomyces cerevisiae

Alignment Length:	234	Identity:	44/234 - (18%)
Similarity:	81/234 - (34%)	Gaps:	73/234 - (31%)

- Green bases have known domain annotations that are detailed below.

Human    40 LTRHAAEALLLSNGCDGSYLLRDSNETTG--LYSLSVR-----------AKDSVKHFHVEYTGYS 91
            :..|..::.:...|..| |.|..|..:.|  :|..|::           ..:..|....:|...:
Yeast   838 VNNHNPDSKIHPRGIPG-YALHPSRNSYGYIIYLPSLKKTVDTTNYVILQNNQTKLDQFDYDTLT 901

Human    92 FKFGFNEFSS-LKDFVKHFANQPLIGSETGTLMVLKHPYPRKVE--------------------- 134
            |....|..:: .:.|::....:......|.:    .|.|..::|
Yeast   902 FDDDLNRLTAHNQSFIEQNETEQSYDQNTES----DHDYQSEIEINSDPLVNDFSSQSLNPLQLD 962

Human   135 -EPSIYESVRVHTAMQTGRTEDDLVPT-----APSLGTKEGYLTKQGGLVKTWKT-----RWFTL 188
             ||  .:.||....:....:|.:::|:     .|.:..||.  |:.||.:::..|     ..||.
Yeast   963 KEP--VQKVRAPKEVDADISEYNILPSTIRSRTPHIINKES--TEMGGTIESDTTSPRHSSTFTA 1023

Human   189 HRNELKYFKDQMSP-EPIRILDLTECSAVQFDYSQERVN 226
                    ::|..| .|..::|||         ||:|||
Yeast  1024 --------RNQKRPGSPNDMIDLT---------SQDRVN 1045

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DAPP1	NP_055210.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20
		SH2_DAPP1_BAM32_like	28..119	CDD:198218	14/92 (15%)
		PH_DAPP1	163..258	CDD:269977	19/70 (27%)
YOR343W-B	NP_620389.3	TYA	17..114	CDD:279373
		gag_pre-integrs	574..641	CDD:290683
		rve	660..778	CDD:279057
		RVT_2	1296..1489	CDD:285028
		RNase_HI_RT_Ty1	1621..1757	CDD:260004
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0017
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900