DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DAPP1 and Socs36E

DIOPT Version :9

Sequence 1:	NP_055210.2	Gene:	DAPP1 / 27071	HGNCID:	16500	Length:	280	Species:	Homo sapiens
Sequence 2:	NP_523593.5	Gene:	Socs36E / 35085	FlyBaseID:	FBgn0041184	Length:	737	Species:	Drosophila melanogaster

Alignment Length:	232	Identity:	53/232 - (22%)
Similarity:	91/232 - (39%)	Gaps:	48/232 - (20%)

- Green bases have known domain annotations that are detailed below.

Human    26 EAELLQDLGWYHGNLTRHAAEALLLSNGCDGSYLLRDSNETTGLYSLSVRAKDSVKHFHVEYTGY 90
            :.|.:.:..:|.|.:.|:.||. ||....:|::|||||.:...|:|::.|......|..:|.:|:
  Fly   465 DLEKITNSSFYWGKMDRYEAEH-LLEGKPEGTFLLRDSAQEEFLFSVTFRKYGRSLHARIEQSGH 528

Human    91 SFKFGFNE---FSSLKDFVKHFANQPLIGSETGTLMVLKHPYPRKVEEPSIYESVRVH-----TA 147
            .|.|..::   |::           |.:   ||.|...|.|......||.:  ::.:|     :.
  Fly   529 KFSFDCHDPCVFTA-----------PTV---TGLLEHYKDPACVMFFEPCL--TIPLHRRQTFSL 577

Human   148 MQTGRTEDDLVPTAPSLGTKEGYLTKQGGLVKTWKTRWFTLHRNELKYFKDQMSPEPIRILDLTE 212
            .|..|.  .:|......|..:..|.   |.:|::...:....:..:|.. ||.:|.|..... .|
  Fly   578 QQLSRA--TIVSNTSYDGINQMELP---GRLKSYLKEYHYKQKLRVKPI-DQNTPMPYYGNVXRE 636

Human   213 CSAVQFDYSQERVNCFCLVFPFRTFYLCAKTGVEADE 249
            ...|.|                 |:|...::|.|.||
  Fly   637 EQQVGF-----------------TYYEDVESGSEVDE 656

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DAPP1	NP_055210.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20
		SH2_DAPP1_BAM32_like	28..119	CDD:198218	24/93 (26%)
		PH_DAPP1	163..258	CDD:269977	18/87 (21%)
Socs36E	NP_523593.5	SH2	463..563	CDD:301589	29/112 (26%)
Socs36E	NP_523593.5	SOCS	575..626	CDD:295349	10/56 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910