Protein Alignment GJB3 and gjb3

DIOPT Version :10

• Sequence 1: NP_076872.1
• Gene: GJB3 / 2707
• HGNCID: 4285
• Length: 270
• Species: Homo sapiens
• Sequence 2: NP_001017685.1
• Gene: gjb3 / 550380
• ZFINID: ZDB-GENE-050417-174
• Length: 304
• Species: Danio rerio
• Alignment Length: 301
• Identity: 181/301 - (60%)
• Similarity: 210/301 - (69%)
• Gaps: 41/301 - (13%)

Human     1 MDWKTLQALLSGVNKYSTAFGRIWLSVVFVFRVLVYVVAAERVWGDEQKDFDCNTKQPGCTNVCY 65
            |||||.|||||||||||||||||||||||||||:||||||||||||||||||||||||||.||||
Zfish     1 MDWKTFQALLSGVNKYSTAFGRIWLSVVFVFRVMVYVVAAERVWGDEQKDFDCNTKQPGCANVCY 65

Human    66 DNYFPISNIRLWALQLIFVTCPSLLVILHVAYREERERRHRQKHGDQCAKLYDNAGKKHGGLWWT 130
            |.|||||:|||||||||.||||||:|::||.|||||||:.:       ||||||.||||||||||
Zfish    66 DFYFPISHIRLWALQLILVTCPSLMVVMHVKYREERERKAK-------AKLYDNTGKKHGGLWWT 123

Human   131 YLFSLIFKLIIEFLFLYLLHTLWHGFNMPRLVQCANVAPCPNIVDCYIARPTEKKIFTYFMVGAS 195
            ||.||..|..||..|||:||.::..|.:||||:| :|.||||:|||||.|||||::|||||||||
Zfish   124 YLISLFAKTGIEITFLYILHHIYDSFYLPRLVKC-DVQPCPNVVDCYIGRPTEKRVFTYFMVGAS 187

Human   196 AVCIVLTICELCYLICHRVLRGLHKDKPRGGCS-PSSSASRASTCRCH---HKLVEAGEVDPD-- 254
            |:||||::||:.|||..|:.|..:|.|.....| |.:...|.....|.   |:|....|..|:
Zfish   188 ALCIVLSVCEIIYLIAKRISRCANKYKRHDKRSTPINQRYRDEDSNCTIPLHELESKPEYKPETK 252

Human   255 --------PG-------------------NNKLQASAPNLT 268
                    ||                   :..::||||||:
Zfish   253 EDFRSEYKPGPKPQFKSEVKPTFKPAYRLSVDMRASAPNLS 293

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GJB3	NP_076872.1	Connexin	2..211	CDD:459638	159/208 (76%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	250..270		10/48 (21%)
gjb3	NP_001017685.1	Connexin	2..202	CDD:459638	158/207 (76%)