Protein Alignment GJB3 and Gjb3

DIOPT Version :10

• Sequence 1: NP_076872.1
• Gene: GJB3 / 2707
• HGNCID: 4285
• Length: 270
• Species: Homo sapiens
• Sequence 2: NP_062113.1
• Gene: Gjb3 / 29585
• RGDID: 2695
• Length: 270
• Species: Rattus norvegicus
• Alignment Length: 270
• Identity: 224/270 - (82%)
• Similarity: 248/270 - (91%)
• Gaps: 0/270 - (0%)

Human     1 MDWKTLQALLSGVNKYSTAFGRIWLSVVFVFRVLVYVVAAERVWGDEQKDFDCNTKQPGCTNVCY 65
            ||||.||.||||||:||||||||||||||||||||||||||||||||||||||||:|||||||||
  Rat     1 MDWKKLQDLLSGVNQYSTAFGRIWLSVVFVFRVLVYVVAAERVWGDEQKDFDCNTRQPGCTNVCY 65

Human    66 DNYFPISNIRLWALQLIFVTCPSLLVILHVAYREERERRHRQKHGDQCAKLYDNAGKKHGGLWWT 130
            ||:||||||||||||||||||||:||||||||||||||:||||||:.|||||.:.||||||||||
  Rat    66 DNFFPISNIRLWALQLIFVTCPSMLVILHVAYREERERKHRQKHGEHCAKLYSHPGKKHGGLWWT 130

Human   131 YLFSLIFKLIIEFLFLYLLHTLWHGFNMPRLVQCANVAPCPNIVDCYIARPTEKKIFTYFMVGAS 195
            ||||||||||||.:|||:||||||||.||||||||:|.||||.||||||||||||:|||||||||
  Rat   131 YLFSLIFKLIIELVFLYVLHTLWHGFTMPRLVQCASVVPCPNTVDCYIARPTEKKVFTYFMVGAS 195

Human   196 AVCIVLTICELCYLICHRVLRGLHKDKPRGGCSPSSSASRASTCRCHHKLVEAGEVDPDPGNNKL 260
            ||||:|||||:||||.||::|||.|||.....|...|:||||||||||||:|:|:::..|.::||
  Rat   196 AVCIILTICEICYLIFHRIMRGLSKDKSTKSISSPKSSSRASTCRCHHKLLESGDLEAVPADDKL 260

Human   261 QASAPNLTPI 270
            |||||:||||
  Rat   261 QASAPSLTPI 270

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GJB3	NP_076872.1	Connexin	2..211	CDD:459638	186/208 (89%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	250..270		10/19 (53%)
Gjb3	NP_062113.1	Connexin	2..211	CDD:459638	186/208 (89%)