Protein Alignment STAU2 and Zn72D

DIOPT Version :10

• Sequence 1: NP_001157852.1
• Gene: STAU2 / 27067
• HGNCID: 11371
• Length: 570
• Species: Homo sapiens
• Sequence 2: NP_788510.1
• Gene: Zn72D / 39764
• FlyBaseID: FBgn0263603
• Length: 884
• Species: Drosophila melanogaster
• Alignment Length: 599
• Identity: 110/599 - (18%)
• Similarity: 182/599 - (30%)
• Gaps: 216/599 - (36%)

Human    47 GEQTWESEGSSIKKAQQAVANKALTESTLPKPVQKPPKSNVNN----NPGSITP-TVELNGLAMK 106
            |..|.....:|:..|||...|          |.|| |....||    ..|:..| ...:.|:..|
  Fly   143 GYDTALYNAASMYVAQQHQGN----------PNQK-PNGGANNWYQRKMGATIPGATAIRGMRPK 196

Human   107 R-----------------GEPAIYRP-LDPKPFPNYRANYNFRGMYN-------QRYHCPVPKIF 146
            .                 ..|..||. |:.:......|:.......|       ..|||.:..:
  Fly   197 APPRPQQLHYCEVCKISCAGPQTYREHLEGQKHKKREASLKMSASANSATQNRGNNYHCELCDV- 260

Human   147 YVQLTVGNNEFFGEGKTRQAARHNAAMKALQALQNEPIPERSP---------------------Q 190
               ...|.:.:....:   .|:|...:|..|.| .:|||...|                     :
  Fly   261 ---TCTGTDAYAAHVR---GAKHQKVVKLHQKL-GKPIPSEEPKKMGKINFVPAAAGGAGVAKTE 318

Human   191 NGESGKDVDDDKDANKSEISLVFEIALKRN----MPVSFEVIKESGPPHMK--SFVTRVSVGEFS 249
            .|.:..|...|.|.|..:       :|..|    .||..|.|:|......|  ||..::...:|:
  Fly   319 GGANESDAAGDLDDNLDD-------SLGENTDNIKPVGGEYIEEVKDEEGKILSFNCKLCDCKFN 376

Human   250 AEGEGNSKKLSKKRAATTVLQELKKLPPLPVVEKPKLFFKKRPKTIVKAGPEYGQGMNPISRLAQ 314
               :.|:|::..| .....||..:|:.|..||:     ||..|:.               .|||:
  Fly   377 ---DPNAKEMHMK-GRRHRLQYKRKVQPDLVVD-----FKPTPRQ---------------RRLAE 417

Human   315 IQQAKKEKEPDYVLLSERG----------MPRRREFVMQVKVGNEVATGTGPNKKIAKKNAAEAM 369
            .:..:.      ::.|.||          ..|.|::..:....|.::...|..::..:..
  Fly   418 ARANRA------MMSSHRGGDDHDGGYWEEQRNRQYNEEYDYNNWMSRSFGGAQRFGRMG----- 471

Human   370 LLQLGYKASTNLQDQLEKTGENKGWSGPKPGF----------PEPTNNTPKGILHLSPDVYQEME 424
                                     :||.|.|          ||.|::......|  .::|.:.|
  Fly   472 -------------------------NGPPPHFGMMPGGNVRRPESTDDRHAIARH--AEIYPKEE 509

Human   425 ASR--HKVISGT--TLGYLSPKDMNQPS---------------------SSFFSISPTSNSSATI 464
            ..:  .:::|.|  .|..:|.....|||                     :..||....:::...:
  Fly   510 ELQTIQRIVSHTERALKLVSDALAEQPSDAGAANKKDKAEKPSEKDGRDNQIFSFQKDADNGGNV 574

Human   465 -------------ARELLMNGTSSTAEAIGLKGSSPT----PPCSPVQPSK--------QLEYLA 504
                         |:.||::| .:..|.:.|....||    ...:.|.|.|        |:.|..
  Fly   575 VRILKGVMRVGYLAKGLLLHG-DNAVELVVLCAEKPTSGLLQRVANVLPDKLKEVAGDTQVNYRV 638

Human   505 RIQGFQAALSALKQ 518
            .:...:|||..|.:
  Fly   639 EVNAEEAALIVLDE 652

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
STAU2	NP_001157852.1	DSRM_SF	3..70	CDD:444671	7/22 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	71..94		7/26 (27%)
		DSRM_STAU2_rpt2	98..179	CDD:380711	16/105 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	181..203		7/42 (17%)
		DSRM_STAU2_rpt3	206..272	CDD:380713	16/71 (23%)
		Nuclear localization signal 1. /evidence=ECO:0000250	273..291		6/17 (35%)
		DSRM_STAU2_rpt4	304..389	CDD:380715	10/94 (11%)
		Nuclear localization signal 2. /evidence=ECO:0000250	373..412		7/48 (15%)
		Required for dendritic transport. /evidence=ECO:0000250	381..570		36/198 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	387..409		7/31 (23%)
		Staufen_C	461..523	CDD:465131	17/83 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	528..570
Zn72D	NP_788510.1	ZnF_U1	205..236	CDD:197732	5/30 (17%)
		C2H2 Zn finger	207..229	CDD:275371	4/21 (19%)
		ZnF_U1	252..284	CDD:197732	7/38 (18%)
		C2H2 Zn finger	255..277	CDD:275371	3/28 (11%)
		ZnF_U1	368..396	CDD:197732	6/31 (19%)
		C2H2 Zn finger	368..390	CDD:275371	4/25 (16%)
		DZF	577..829	CDD:128842	17/77 (22%)