DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fkbp9 and Fkbp14

DIOPT Version :9

Sequence 1:	NP_036186.2	Gene:	Fkbp9 / 27055	MGIID:	1350921	Length:	570	Species:	Mus musculus
Sequence 2:	NP_001246448.1	Gene:	Fkbp14 / 37449	FlyBaseID:	FBgn0010470	Length:	220	Species:	Drosophila melanogaster

Alignment Length:	205	Identity:	72/205 - (35%)
Similarity:	109/205 - (53%)	Gaps:	31/205 - (15%)

- Green bases have known domain annotations that are detailed below.

Mouse   379 PPDCSVLSKKGDYLKYHYNASL-LDGTLLDSTWNLGKTYNIVLGSGQVVLGMDMGLREMCVGEKR 442
            |..|...||.||.|..||..:| .||...||:::..:.:...||:|||:.|.|.||..|||||||
  Fly    34 PEVCEQKSKNGDSLTMHYTGTLQADGKKFDSSFDRDQPFTFQLGAGQVIKGWDQGLLNMCVGEKR 98

Mouse   443 TVIIPPHLGYGEAGVDGEVPGSAVLVFDIELLELVSGLPEGYMFIWNGEVSPNLFEEIDRDGNGE 507
            .:.|||.||||:.|....:|..|.|:||:||:.           |.|...:.|:|:|||.:.:.:
  Fly    99 KLTIPPQLGYGDQGAGNVIPPKATLLFDVELIN-----------IGNAPPTTNVFKEIDDNADKQ 152

Mouse   508 VLLEE----FSEYIHAQVATGKGK--------LAPGFNAEMIVKNMFTNQDRNGDGKVTAEEFKL 560
            :..||    .|||:..|:...:|:        ||..   :.:|:.:|.::|::.:|.::.:||
  Fly   153 LSREEVIVYVSEYLKKQMTAVEGQDSEELKNMLAEN---DKLVEEIFQHEDKDKNGFISHDEF-- 212

Mouse   561 KDQEAKHDEL 570
              ...|||||
  Fly   213 --SGPKHDEL 220

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fkbp9	NP_036186.2	FKBP_C	47..139	CDD:278674
		FKBP_C	159..251	CDD:278674
		FKBP_C	271..362	CDD:278674
		FKBP_C	382..474	CDD:278674	43/92 (47%)
		EF-hand_7	495..559	CDD:290234	19/75 (25%)
		EFh	497..558	CDD:238008	17/72 (24%)
		Prevents secretion from ER. /evidence=ECO:0000255\|PROSITE-ProRule:PRU10138	567..570		2/2 (100%)
Fkbp14	NP_001246448.1	FKBP_C	37..130	CDD:278674	43/92 (47%)
		EF-hand_7	140..212	CDD:290234	18/74 (24%)
		EFh	141..212	CDD:298682	17/73 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0545
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1507309at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820