DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Omd and CG18095

DIOPT Version :9

Sequence 1:	NP_001347637.1	Gene:	Omd / 27047	MGIID:	1350918	Length:	423	Species:	Mus musculus
Sequence 2:	NP_001188805.1	Gene:	CG18095 / 34823	FlyBaseID:	FBgn0028872	Length:	564	Species:	Drosophila melanogaster

Alignment Length:	330	Identity:	81/330 - (24%)
Similarity:	150/330 - (45%)	Gaps:	65/330 - (19%)

- Green bases have known domain annotations that are detailed below.

Mouse    93 IQQLNLQFNDIEAVTANSFINATHLKEINLSHNKIKSQKIDYGVFAKLSNLQQLHLEHNNLEEF- 156
            :|||:|::|.|..:..:||...:|||.:.|:.|::  ..||...|..|..|..|.|:||.:|..
  Fly   137 LQQLDLRYNRISQIENDSFDGLSHLKHLYLNGNQL--AHIDGSFFRGLHRLSSLSLQHNRIEFIE 199

Mouse   157 --PFPLPKSLERLLLGYNEISILPTNAMDGLVNVTM------------------------LDLCY 195
              .|.....|..|.|..|.:|.|...:..||..:..                        |||.|
  Fly   200 MDSFESNTHLRSLRLDQNLLSSLQFLSQRGLARLVHLNLSSNLLQKLEPFVFSKNFELQDLDLSY 264

Mouse   196 NHLSDSMLKEKTLSKMEKLMQLNLCNNRLESM---PLGLPSSLMYLSLENNSISSIPDNYFDKLP 257
            |::  :.|.::.||.::.|.:||:.:|.::.:   .|....:|:.|.:..|.::::|||.|....
  Fly   265 NNI--TKLNKEALSGLDSLERLNISHNYVDKIYDESLDSLIALLQLDISFNLLTTLPDNLFHFNT 327

Mouse   258 KLHALRISHNKLEDIPYD-IFNLSNLIELNVGHNKLKQAFYIPR-----NLEHLY--LQNNEIES 314
            :|..:.:::||:|:|... :||.::|..:.:..|.:..|.::.|     |...||  |.:|.::|
  Fly   328 QLEEIILANNKIEEISSQMMFNQNHLRYIKLSGNAISDAAFLDRLSPSVNRFTLYVDLSSNRLKS 392

Mouse   315 INVTMICPSPDPVHHHHLTYLRVDQN---------KLKEPISSYIFFCFP--RIHSIYYGEQRST 368
            :|::.:.         |..|:.:..|         .|.:.:.:.:.|..|  .|:::   .:.:|
  Fly   393 LNLSSLL---------HFRYINLADNNWSCNWLVANLVQKLPNSVNFARPWTVINNL---SENTT 445

Mouse   369 NGETI 373
            |.|.|
  Fly   446 NVEGI 450

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Omd	NP_001347637.1	PRK15370	<68..>302	CDD:185268	63/244 (26%)
		leucine-rich repeat	74..92	CDD:275380
		LRR 1	92..113		8/19 (42%)
		leucine-rich repeat	94..116	CDD:275380	8/21 (38%)
		LRR 2	116..129		5/12 (42%)
		leucine-rich repeat	117..142	CDD:275380	8/24 (33%)
		LRR 3	142..164		7/24 (29%)
		leucine-rich repeat	143..163	CDD:275380	7/22 (32%)
		leucine-rich repeat	164..187	CDD:275380	8/22 (36%)
		LRR 4	165..184		5/18 (28%)
		LRR 5	187..207		6/43 (14%)
		leucine-rich repeat	188..213	CDD:275380	8/48 (17%)
		LRR 6	213..233		5/22 (23%)
		leucine-rich repeat	214..234	CDD:275380	5/22 (23%)
		LRR 7	234..255		7/20 (35%)
		leucine-rich repeat	235..258	CDD:275380	7/22 (32%)
		LRR 8	258..279		6/21 (29%)
		leucine-rich repeat	259..281	CDD:275380	7/22 (32%)
		LRR 9	281..294		2/12 (17%)
		leucine-rich repeat	282..301	CDD:275380	4/23 (17%)
		LRR 10	301..322		7/22 (32%)
		LRR 11	331..353		4/30 (13%)
		leucine-rich repeat	332..351	CDD:275380	3/27 (11%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	381..406
CG18095	NP_001188805.1	leucine-rich repeat	41..64	CDD:275380
		LRR_8	64..123	CDD:290566
		leucine-rich repeat	65..88	CDD:275380
		leucine-rich repeat	89..112	CDD:275380
		leucine-rich repeat	113..136	CDD:275380
		LRR_RI	115..384	CDD:238064	66/250 (26%)
		LRR_8	135..195	CDD:290566	22/59 (37%)
		leucine-rich repeat	137..160	CDD:275380	8/22 (36%)
		leucine-rich repeat	161..184	CDD:275380	8/24 (33%)
		LRR_8	184..243	CDD:290566	15/58 (26%)
		leucine-rich repeat	185..208	CDD:275380	7/22 (32%)
		leucine-rich repeat	209..232	CDD:275380	8/22 (36%)
		LRR_8	232..289	CDD:290566	11/58 (19%)
		leucine-rich repeat	233..256	CDD:275380	0/22 (0%)
		leucine-rich repeat	257..280	CDD:275380	8/24 (33%)
		LRR_8	280..339	CDD:290566	14/58 (24%)
		leucine-rich repeat	281..304	CDD:275380	5/22 (23%)
		leucine-rich repeat	305..328	CDD:275380	7/22 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45712
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010