DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PKD2L2 and pkd2

DIOPT Version :9

Sequence 1:	NP_001287850.1	Gene:	PKD2L2 / 27039	HGNCID:	9012	Length:	624	Species:	Homo sapiens
Sequence 2:	NP_001002310.1	Gene:	pkd2 / 432387	ZFINID:	ZDB-GENE-040827-4	Length:	904	Species:	Danio rerio

Alignment Length:	662	Identity:	290/662 - (43%)
Similarity:	426/662 - (64%)	Gaps:	61/662 - (9%)

- Green bases have known domain annotations that are detailed below.

Human    21 KEVEITTTLQELLLYFIFLINLCILTFGMVNPHMYYLNKVMSSLFLDTSVPGEERTNFKSIRSIT 85
            :|:.:.|.|:|::.|.:||:.|||:|:|||:.:|||..||||.|||||.:...|.|||||:.::.
Zfish   149 REMYLKTVLREMITYILFLLTLCIITYGMVSTNMYYYTKVMSQLFLDTPLSSGEPTNFKSLSTME 213

Human    86 DFWKFMEGPLLEGLYWDSWYNNQQLYNLKNSSRIYYENILLGVPRVRQLKVRNNTCKVYSSFQSL 150
            |||||.|||.|.|:||:.||||:.|  .:|.|.|||||:||||||:|||:|||.:|.|:...:..
Zfish   214 DFWKFTEGPFLNGMYWELWYNNKSL--PENQSLIYYENLLLGVPRLRQLRVRNESCSVHEDLRDE 276

Human   151 MSECYGKYTSANEDLSNFGLQINTEWRY-STSNTNSPWHWGFLGVYRNGGYIFTLSKSKSETKNK 214
            :.:||..|:.||||.:.||.:..|.||: ..|:.....:||.:..|..|||...||:::.::.|:
Zfish   277 VYDCYNVYSPANEDKAPFGPKNGTAWRFKDESSLGESSYWGQVSTYGGGGYYQDLSRTREKSANQ 341

Human   215 FIDLRLNSWITRGTRVIFIDFSLYNANVNLFCIIRLVAEFPATGGILTSWQFYSVKLLRYVSYYD 279
            ..:|:.|.|:.||||.:|:|||:||.|||||||:||:.|||||||.:.||||.:|:||||||.:|
Zfish   342 LQELKNNLWLDRGTRAVFLDFSIYNGNVNLFCIVRLLVEFPATGGAVPSWQFQTVRLLRYVSSWD 406

Human   280 YFIASCEITFCIFLFVFTTQEVKKIKEFKSAYFKSIWNWLELLLLLLCFVAVSFNTYYNVQIFLL 344
            ||:..||::||:|:..:..:|..:|:..:..||||:||.|::|::.|...|:..|......:...
Zfish   407 YFVGMCEVSFCLFVLYYLVEEALEIRLHRLRYFKSLWNCLDVLIVALSVPAIIMNICRTSAVSHR 471

Human   345 LGQLLKSTEKYSDFYFLACWHIYYNNIIAITIFFAWIKIFKFISFNKTMSQLSSTLSRCVKDIVG 409
            |..||::...|.:|..||...:::||:.||.:|.:|:|:||||:|||||:|||:|:|||.||::|
Zfish   472 LHFLLENHSTYPNFEPLARLQVHFNNLAAIIVFLSWVKLFKFINFNKTMNQLSTTMSRCAKDLMG 536

Human   410 FAIMFFIIFFAYAQLGFLVFGSQVDDFSTFQNSIFAQFRIVLGDFNFAGIQQANPILGPIYFITF 474
            |||||||:|.|||||.:||||:||:||||||..||.||||:||||:|:.|::|:.:||||||.||
Zfish   537 FAIMFFIVFLAYAQLAYLVFGTQVNDFSTFQACIFTQFRIILGDFDFSEIEEADSVLGPIYFTTF 601

Human   475 IFFVFFVLLNMFLAIINDTYSEVKADYSIGRRLDFELGKMIKQSYKNVLEKFRLKKAQKDE--DK 537
            :||:|.:|||||||||||||||||||.: .:|.:.|:..:||:||...:.|.:|||:..::  |.
Zfish   602 VFFIFMILLNMFLAIINDTYSEVKADMA-QQRSEMEITDLIKKSYNRAMVKLKLKKSSINDIPDS 665

Human   538 KTKGSG-----DLAEQARREGFDENEI---------------------QNAEQMKKWKERLEKKY 576
            ..:.:|     :|.:..|.:|..:.||                     |..:.::|.:|.|:.::
Zfish   666 LQQAAGKLSFDELRQDLRGKGHSDAEIEAIFAKYDLDGDQELTEHEHQQMRDDLEKEREDLDLEH 730

Human   577 YSM----------EIQDDYQP-------------------VTQEEFRELFLYAVELEKELHYINL 612
            .|:          ..|||.:.                   |:.|||:.|......:|..:..|..
Zfish   731 SSLPRPASGRSFSRSQDDSEEDDDEDSGHSSRRRGSSSGGVSYEEFQVLVRRVDRMEHSIGSIVS 795

Human   613 KLNQVVRKVSAL 624
            |::.|:.|:.|:
Zfish   796 KIDAVIVKLEAM 807

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PKD2L2	NP_001287850.1	PKD_channel	76..497	CDD:332708	222/421 (53%)
pkd2	NP_001002310.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..102
		PKD_channel	204..624	CDD:285288	222/421 (53%)
		Selectivity filter. /evidence=ECO:0000250\|UniProtKB:Q13563	578..580		1/1 (100%)
		EFh	<671..715	CDD:324233	6/43 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	708..770		8/61 (13%)
		Linker. /evidence=ECO:0000250\|UniProtKB:Q13563	740..759		3/18 (17%)
		Pkinase	<781..>856	CDD:330832	6/27 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	854..904
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3599
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D205541at33208
OrthoFinder	1	1.000	-	-		FOG0002518
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1653
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.820