Protein Alignment PKD2L2 and brv1

DIOPT Version :10

• Sequence 1: NP_001287850.1
• Gene: PKD2L2 / 27039
• HGNCID: 9012
• Length: 624
• Species: Homo sapiens
• Sequence 2: NP_649116.1
• Gene: brv1 / 40116
• FlyBaseID: FBgn0036874
• Length: 728
• Species: Drosophila melanogaster
• Alignment Length: 659
• Identity: 141/659 - (21%)
• Similarity: 257/659 - (38%)
• Gaps: 131/659 - (19%)

Human     8 HRGGASKHKLHYR---KEVEITTTLQELLLYFIFLINLCILTFGMVNPHMYYLNKVMSSLFLDTS 69
            ||.  .:..|.||   :|:.:|..|  .|:||       .:.....:..:|:..:....||   .
  Fly   109 HRN--ERVNLKYRLITEELWLTGKL--FLVYF-------FMALAFFDELLYFNTEATELLF---Q 159

Human    70 VPGEERTNFKSIRSITDFWKFMEGPLLEGLYWDSWYNNQQLYNLKNSSR----IYYENI-LLGVP 129
            ....:.....|:..:.|.:.|:...|:.. :.|.          ||:|.    |:.|.. ||||.
  Fly   160 CNHGDAFGLLSVGDVPDIYFFVVSSLVLA-FTDG----------KNTSGGAPWIHAEGTRLLGVV 213

Human   130 RVRQLKVRNN---------TCKVYSSFQSLMSECYGKYTSANEDLSNFGLQINTEWRYSTSNTNS 185
            |:|||:..:|         |.:.:|...:|..|.. .||...       ..|.|.|..|.|....
  Fly   214 RLRQLRTESNRLGLSLPVFTERDFSESWTLPYERV-PYTDKY-------WPIYTPWLPSVSVARD 270

Human   186 PWHWGFLGVYRNGGYIFTLSKSK------SETKN---KFID-LRLNSWITRGTRVIFIDFSLYNA 240
            ....|...|    |::|...:||      |:|::   |.|| |...:|:...|..:|:|||||||
  Fly   271 NLLMGINHV----GHMFNYPESKGYKVLLSDTRHKSLKIIDYLMKKNWLDANTTALFMDFSLYNA 331

Human   241 NVNLFCIIRLVAE-----FPATGGILTSWQFYSVKLLRYVSYYDYFIASCEITFCIFLFVFTTQE 300
            :.|.|.:..|..|     :|.....:.|..|  |:.||..:.:...:        :|:||.|.
  Fly   332 DANTFTVCTLWVEKFPYQYPDGHTRIESHTF--VEQLREFTKFGMLM--------VFVFVVTW-- 384

Human   301 VKKIKEFKSAYFKSIWN--------WLE---LLLLLLCFVAVSFNTYYNVQIFLLLGQLLKSTE- 353
                .:|..|:|..:|.        |::   :::.|...|.:..:...|     |:.:::||.|
  Fly   385 ----LQFTKAFFLKVWYDPRQLKTLWVQVDAMIVALSLVVGMIMSVRDN-----LVQKMIKSVEI 440

Human   354 ----KYSDFYFLACWHIYYNNIIAITIFFAWIKIFKFISFNKTMSQLSSTLSRCVKDIVGFAIMF 414
                .:.||...|......:.:..:.:....::::|.:.|:.|....:.|::.....::...::.
  Fly   441 AVVVDFLDFREPAQLAYLEDVVTGLAVALVTMRLWKVLQFSATFQLFTKTIAMAWDALLCTFVIT 505

Human   415 FIIFFAYAQLGFLVFGSQVDDFSTFQNSIFAQFRIVLGDFNFA---GIQQANPILGPIYFITFIF 476
            .|...|.......:.|:...:|..|...|........|..|..   .|......||.:.:....|
  Fly   506 VIFIIAIGIATVTINGNYTSNFRDFPKGIVTVTCFAFGYTNLVYPPDIFYGGEWLGILLYTIMGF 570

Human   477 FVFFVLLNMFLAIINDTYSEVKA--DYSIGRRLDFELGKMIKQSYKNVLEKF-RLKKAQKDEDKK 538
            .|.::|:|:.::::.|..:.|||  |..:.:|:.|  .:.::..|.:.:... ::...||...:|
  Fly   571 VVKYMLINLIVSMMRDQMASVKADRDKKVRQRITF--WQFLRVEYAHFINYIVKVFHCQKGYQRK 633

Human   539 TKGSGDLAEQARREGFDENEIQNAEQMKKWKERLEKKY----YSMEIQDDYQPVTQEEFRELFLY 599
            .:   .:|:..:|:       .|:.::|:.|.::...|    |.|.|..|.:   |.::||....
  Fly   634 NR---TVAQNIQRK-------LNSNELKRRKTKISSIYSETIYVMPIDKDLE---QMKYRERIER 685

Human   600 AVELEKELH 608
            ...|...||
  Fly   686 TFTLAAILH 694

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PKD2L2	NP_001287850.1	Polycystin_dom	77..272	CDD:466668	60/223 (27%)
		PKD_channel	273..497	CDD:462341	40/242 (17%)
brv1	NP_649116.1	Polycystin_dom	167..363	CDD:466668	59/220 (27%)
		PKD_channel	364..591	CDD:462341	41/245 (17%)