Protein Alignment PKD2L2 and pkd2l1

DIOPT Version :9

• Sequence 1: NP_001287850.1
• Gene: PKD2L2 / 27039
• HGNCID: 9012
• Length: 624
• Species: Homo sapiens
• Sequence 2: XP_002936910.2
• Gene: pkd2l1 / 100495064
• XenbaseID: XB-GENE-954499
• Length: 832
• Species: Xenopus tropicalis
• Alignment Length: 653
• Identity: 300/653 - (45%)
• Similarity: 424/653 - (64%)
• Gaps: 60/653 - (9%)

Human    21 KEVEITTTLQELLLYFIFLINLCILTFGMVNPHMYYLNKVMSSLFLDTSVPGEERTNFKSIRSIT 85
            :|:.|.|||:|||:|.:||:::|:||:||.:.:.||...|||.|||||.  .:....||:|.::.
 Frog   105 RELYIKTTLRELLVYIVFLVDICLLTYGMTSTNTYYYTNVMSKLFLDTQ--SDSGVTFKAISNMD 167

Human    86 DFWKFMEGPLLEGLYWDSWYNNQQLYNLKNSSRIYYENILLGVPRVRQLKVRNNTCKVYSSFQSL 150
            |||.:::||:|:||||..||||..|.:..| |.|||||:||||||:|||||:||:|.||..|:..
 Frog   168 DFWSYLQGPMLDGLYWTKWYNNVSLTDNTN-SLIYYENLLLGVPRMRQLKVKNNSCMVYKDFKDE 231

Human   151 MSECYGKYTSANEDLSNFGLQINTEWRYST-SNTNSPWHWGFLGVYRNGGYIFTLSKSKSETKNK 214
            :..|:..|:...||.|.|||...|.|.|.| .......:||.:..|..|||...|..:|.::..:
 Frog   232 IVGCFDVYSKDKEDTSQFGLINGTAWTYYTEEELGGSSYWGKITTYSGGGYYIDLELTKRDSLRQ 296

Human   215 FIDLRLNSWITRGTRVIFIDFSLYNANVNLFCIIRLVAEFPATGGILTSWQFYSVKLLRYVSYYD 279
            ...|:.|.|:.||||.:|:|||:||||:||||::|||.|||||||.:.|||..:|||:||||.:|
 Frog   297 LQTLKSNLWLDRGTRAVFVDFSVYNANINLFCVLRLVVEFPATGGAIPSWQIRTVKLIRYVSGWD 361

Human   280 YFIASCEITFCIFLFVFTTQEVKKIKEFKSAYFKSIWNWLELLLLLLCFVAVSFNTYYNVQIFLL 344
            |||..|||.||||:|.:..:|:.:::..|..||.||||.|:::::||..||:.|:.:..:::..|
 Frog   362 YFIIGCEIVFCIFIFYYVVEEILELRIHKFRYFTSIWNILDVIVILLSLVAIGFHIFRTMEVNRL 426

Human   345 LGQLLKSTEKYSDFYFLACWHIYYNNIIAITIFFAWIKIFKFISFNKTMSQLSSTLSRCVKDIVG 409
            :|.|||:...|:||.|||.|...|||:.|:.:|||||||||:|||||||:||||||:||.|||:|
 Frog   427 MGTLLKNPTIYADFEFLAFWQTQYNNMNAVNLFFAWIKIFKYISFNKTMTQLSSTLARCAKDILG 491

Human   410 FAIMFFIIFFAYAQLGFLVFGSQVDDFSTFQNSIFAQFRIVLGDFNFAGIQQANPILGPIYFITF 474
            |||||||:||||||||:|:||:||::||||...||.||||:||||::..|..||.:||||||:|:
 Frog   492 FAIMFFIVFFAYAQLGYLLFGTQVENFSTFVKCIFTQFRIILGDFDYDAIDNANRVLGPIYFVTY 556

Human   475 IFFVFFVLLNMFLAIINDTYSEVKADYSIGRRLDFELGKMIKQSYKNVLEKFRLKKAQKDEDKKT 539
            :|||||||||||||||||||||||.:.| .::.:.:...::||.||..|.|.:|||.:..:.:|.
 Frog   557 VFFVFFVLLNMFLAIINDTYSEVKEELS-NQKNELQFSDILKQGYKKTLLKLKLKKERISDVQKA 620

Human   540 KGSG-------DLAEQARREGFDENEIQNA---------------EQMKKWK------------- 569
            ..:|       :.....|..|.|::||..|               |||:..:
 Frog   621 LQNGNKELKFEEFKNSLREMGHDDHEISAAFSNFDQDGNRILDEEEQMRMKQILEERRVALNAEI 685

Human   570 ---------ERLEKKYYSMEIQDDYQP----VTQEEFRELFLYAVELEKELHYINLKLNQVVRKV 621
                     :|||::....:|::|...    |:|:||: :||      |.|..:...::.::||:
 Frog   686 ENLGRSYRNKRLEEEVNLDDIKNDISSKGSWVSQDEFK-IFL------KRLQQLEFSISGIMRKI 743

Human   622 SAL 624
            .::
 Frog   744 ESV 746

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PKD2L2	NP_001287850.1	PKD_channel	76..497	CDD:332708	235/421 (56%)
pkd2l1	XP_002936910.2	PKD_channel	160..579	CDD:369653	235/419 (56%)
		SCP-1	<573..809	CDD:114219	44/182 (24%)
		Fer4_24	717..751	CDD:375558	10/37 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D205541at33208
OrthoFinder	1	1.000	-	-		FOG0002518
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1653
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	4.010