DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment SIGLEC7 and side-II

DIOPT Version :9

Sequence 1:NP_055200.1 Gene:SIGLEC7 / 27036 HGNCID:10876 Length:467 Species:Homo sapiens
Sequence 2:NP_001014485.3 Gene:side-II / 3346206 FlyBaseID:FBgn0259213 Length:1064 Species:Drosophila melanogaster


Alignment Length:625 Identity:117/625 - (18%)
Similarity:182/625 - (29%) Gaps:249/625 - (39%)


- Green bases have known domain annotations that are detailed below.


Human     1 MLLLLLLPLLW-------------------------GRERVEGQKSNRKDYSLTMQSSVTVQEGM 40
            |:|||.:.||.                         |.....|..|::..:..|  ..:...||.
  Fly     1 MVLLLAMALLMPVTLARLHSTSGVGMSGGGSSMGPGGGGSGSGGISSKDSHVKT--KDIDAVEGK 63

Human    41 CVHVRCSFSYPVDSQTDSDPVHGY---WFRAGNDI-----------------SWKAPVATNNPAW 85
            .|.:.|..:.|:|:.        |   |||....|                 .|.||....    
  Fly    64 SVSLPCPITEPLDNV--------YMVLWFRDNAGIPLYSFDVRDKESREQPRHWSAPEVFG---- 116

Human    86 AVQEETRDRFHLLGDPQTKNCTLSIR-----------DARMSDAGRYFFRM------EKGNI--K 131
                 :|.:||....|    .||.|:           |.|.|....:.|.:      |:..|  :
  Fly   117 -----SRAKFHFDSQP----ATLEIKRHDQGIYRCRVDFRTSQTQSFRFNLSVIILPEQPIIMDR 172

Human   132 WNYKY-----------DQLSVNVTALTHRP---------------------------NILIPGTL 158
            |..:.           |.:.:....:..||                           .:|.|...
  Fly   173 WGRQLNGTQLGPKQEGDDIVITCRVVGGRPQPQVRWLVNGLLVDNQNEHNSGDVIENRLLWPSVQ 237

Human   159 ESGCFQNLTCSV---------------------------------------PWACE-QGTPP--M 181
            .:......||..                                       ..:|| .|:.|  :
  Fly   238 RNDLNSVFTCQALNTQLDKPKEKSFILDMHLKPLVVKILEPPSSMIADRRYEVSCESSGSRPNAI 302

Human   182 ISW------MGTSVSPLHPSTTRSSVLTLIPQPQHHGTSLTCQVTLPGA-GVTTNRTIQLNVSYP 239
            |:|      :..:...:..::|||. |:.:|.....|.|:||:...|.. |:......:|||.||
  Fly   303 ITWYKGKRQLRRTKDDISKNSTRSE-LSFVPTTDDDGKSITCRAENPNVNGLYLETMWKLNVVYP 366

Human   240 PQNLTVTVFQGEGTASTALGNSSSLS---VLEGQSLRLVCAVDSNPPAR-LSWTWRSLTLYPS-- 298
            |   .||:..|           |:|:   :.||..:...|.|.|||..| |.|....:.|..:  
  Fly   367 P---LVTLRLG-----------STLTPDDIKEGDDVYFECHVQSNPQWRKLLWLHNGIHLEHNTS 417

Human   299 ----QPSNPLVLE-LQVHLGDEGEFTCRAQNSLGSQHVSLNLSLQQEYTGKMRPVSGVLLGAVGG 358
                :.:..|||: :..|..  |.:.|.|.|..| :.||..|.|:.:||...:....|:|     
  Fly   418 ARVIRSNQSLVLQKITKHYA--GNYACSAINDEG-ETVSNQLPLRVKYTPMCKHADRVIL----- 474

Human   359 AGATALVFLSFCVIFIVVRSCRKKSARPAADVGDIGMKDANTIRGSASQGNLTESWADDNPRHHG 423
                                              ||.....|:.      .:.|..||..||...
  Fly   475 ----------------------------------IGASKDETVE------VVCEIQADPPPRTFR 499

Human   424 LAAHSSGEEREIQYAPLSFHKGEPQDLSGQEATNNEYSEI 463
            ...::|||..::.....|.: |....|.....|:.:|..:
  Fly   500 WKFNNSGETLDVGSERFSVN-GSRSILKYTPVTDQDYGTL 538

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SIGLEC7NP_055200.1 Ig_Siglec_N 26..144 CDD:143189 30/167 (18%)
Sialic acid binding. /evidence=ECO:0000269|PubMed:12438315, ECO:0000269|PubMed:16623661, ECO:0000269|PubMed:16895906 131..135 1/3 (33%)
Ig 150..223 CDD:325142 20/147 (14%)
IG_like 261..336 CDD:214653 24/85 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 401..431 6/29 (21%)
ITIM motif 435..440 0/4 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 443..467 4/21 (19%)
side-IINP_001014485.3 IG_like 55..160 CDD:214653 25/125 (20%)
Ig 57..160 CDD:299845 25/123 (20%)
Ig 188..251 CDD:299845 7/62 (11%)
Ig 289..363 CDD:299845 18/74 (24%)
IG_like 289..351 CDD:214653 16/62 (26%)
Ig_2 376..460 CDD:290606 25/86 (29%)
IG_like 383..454 CDD:214653 21/73 (29%)
Ig 470..548 CDD:299845 18/115 (16%)
IG_like 481..557 CDD:214653 14/65 (22%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
00.000

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