Protein Alignment ATP2C1 and SERCA

DIOPT Version :10

• Sequence 1: NP_001365440.1
• Gene: ATP2C1 / 27032
• HGNCID: 13211
• Length: 983
• Species: Homo sapiens
• Sequence 2: NP_726381.1
• Gene: SERCA / 49297
• FlyBaseID: FBgn0263006
• Length: 1020
• Species: Drosophila melanogaster
• Alignment Length: 1003
• Identity: 342/1003 - (34%)
• Similarity: 517/1003 - (51%)
• Gaps: 155/1003 - (15%)

Human    65 VSEVASILQADLQNGLNKCEVSHRRAFHGWNEFDISEDEPLWKKYISQFKNPLIMLLLASAVISV 129
            |.:..:....|.:.||...::...:..:|.||....|.:.:|:..:.||.:.|:.:||.:|:||.
  Fly     9 VEQSLNFFGTDPERGLTLDQIKANQKKYGPNELPTEEGKSIWQLVLEQFDDLLVKILLLAAIISF 73

Human   130 LMHQFDD-------AVSITVAILIVVTVAFV---QEYRSEKSLEELSKLVPPECHCVREGK--LE 182
            ::..|::       .|...|.:||::..|.|   ||..:|.::|.|.:..|.....||:.|  ::
  Fly    74 VLALFEEHEETFTAFVEPLVILLILIANAVVGVWQERNAESAIEALKEYEPEMGKVVRQDKSGIQ 138

Human   183 HTLARDLVPGDTVCLSVGDRVPADLRL--FEAVDLSIDESSLTGETTPCSKVT--APQPAATNGD 243
            ...|:::||||.|.:||||::|||:|:  ..:..|.||:|.||||:....|.|  .|.|.|.|.|
  Fly   139 KVRAKEIVPGDLVEVSVGDKIPADIRITHIYSTTLRIDQSILTGESVSVIKHTDAIPDPRAVNQD 203

Human   244 LASRSNIAFMGTLVRCGKAKGVVIGTGENSEFGEVFKMMQAEEAPKTPLQKSMDLLGKQLSFYSF 308
               :.||.|.||.|..|||:|||||||.::..|::...|...|..|||||:.:|..|:|||
  Fly   204 ---KKNILFSGTNVAAGKARGVVIGTGLSTAIGKIRTEMSETEEIKTPLQQKLDEFGEQLS---- 261

Human   309 GIIGIIMLVGWLLG--------------KDILEMFTISVSLAVAAIPEGLPIVVTVTLALGVMRM 359
            .:|.:|.:..|.:.              |..:..|.|:|:|||||||||||.|:|..||||..||
  Fly   262 KVISVICVAVWAINIGHFNDPAHGGSWIKGAIYYFKIAVALAVAAIPEGLPAVITTCLALGTRRM 326

Human   360 VKKRAIVKKLPIVETLGCCNVICSDKTGTLTKNEMTVTHIFTSDG--------LHAEVTGVGYNQ 416
            .||.|||:.||.||||||.:|||||||||||.|:|:|:.:|..|.        |..|:||..|..
  Fly   327 AKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVSRMFIFDKVEGNDSSFLEFEMTGSTYEP 391

Human   417 FGEVIVDGDVVHGFYNPAVSRIVEAGCVCNDAVIRNNTL------MGKPTEGALIALAMKM---- 471
            .|||.::|..:.......:..:.....:|||:.|..|..      :|:.||.|||.||.|:
  Fly   392 IGEVFLNGQRIKAADYDTLQELSTICIMCNDSAIDYNEFKQAFEKVGEATETALIVLAEKLNSFS 456

Human   472 ----GLD----------GLQQDYIRKAEYPFSSEQKWMAVKCVHRTQQDR----PEICFMKGAYE 518
                |||          .::..:.::....||.::|.|:..|. ..:..|    |:: |:|||.|
  Fly   457 VNKSGLDRRSAAIACRGEIETKWKKEFTLEFSRDRKSMSSYCT-PLKASRLGTGPKL-FVKGAPE 519

Human   519 QVIKYCT-----------TYQSKGQTLTLTQQQ---RDVYQQEKARMGSAGLRVLAL--ASGP-- 565
            .|::.||           |...|.:.|.||.|.   ||.            ||.|||  |..|
  Fly   520 GVLERCTHARVGTTKVPLTSALKAKILALTGQYGTGRDT------------LRCLALAVADSPMK 572

Human   566 ----ELG----------QLTFLGLVGIIDPPRTGVKEAVTTLIASGVSIKMITGDSQETAVAIAS 616
                :||          .|||:|:||::||||..|.:::....|:|:.:.:||||::.||.||..
  Fly   573 PDEMDLGDSTKFYQYEVNLTFVGVVGMLDPPRKEVFDSIVRCRAAGIRVIVITGDNKATAEAICR 637

Human   617 RLGLYSK----TSQSVSGEEIDAMDVQQLSQIVPKVAVFYRASPRHKMKIIKSLQKNGSVVAMTG 677
            |:|::::    |.:|.||.|.|.:...:....|.:..:|.|..|:||.||::.||....:.||||
  Fly   638 RIGVFAEDEDTTGKSYSGREFDDLSPTEQKAAVARSRLFSRVEPQHKSKIVEFLQSMNEISAMTG 702

Human   678 DGVNDAVALKAADIGVAMGQTGTDVCKEAADMILVDDDFQTIMSAIEEGKGIYNNIKNFVRFQLS 742
            ||||||.|||.|:||:||| :||.|.|.||:|:|.||:|.:|:||:|||:.||||:|.|:|:.:|
  Fly   703 DGVNDAPALKKAEIGIAMG-SGTAVAKSAAEMVLADDNFSSIVSAVEEGRAIYNNMKQFIRYLIS 766

Human   743 TSIAALTLISLATLMNFPNPLNAMQILWINIIMDGPPAQSLGVEPVDKDVIRKPPRNWKDSILTK 807
            ::|..:..|.|...:..|..|..:|:||:|::.||.||.:||..|.|.|::.||||...:.:::.
  Fly   767 SNIGEVVSIFLTAALGLPEALIPVQLLWVNLVTDGLPATALGFNPPDLDIMEKPPRKADEGLISG 831

Human   808 NLILKILVSSIIIVCGTL------FVF---------WR------------ELR--DNVI--TPRD 841
            .|..:.:.....:...|:      |||         |:            |.:  |..|  .|..
  Fly   832 WLFFRYMAIGFYVGAATVGAAAWWFVFSDEGPKLSYWQLTHHLSCLGGGDEFKGVDCKIFSDPHA 896

Human   842 TTMTFTCFVFFDMFNALSSRSQTKSVFEIGLCSNRMFCYAVLGSIMGQLLVIYFPPLQKVFQTES 906
            .||..:..|..:|.||::|.|:.:|:..:....|.....::..|.....:::|...|..|||...
  Fly   897 MTMALSVLVTIEMLNAMNSLSENQSLITMPPWCNLWLIGSMALSFTLHFVILYVDVLSTVFQVTP 961

Human   907 LSILDLLFLLGLTSSVCIVAEIIKKVER 934
            ||..:.:.::..:..|.::.|.:|.|.|
  Fly   962 LSAEEWITVMKFSIPVVLLDETLKFVAR 989

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ATP2C1	NP_001365440.1	ATPase-IIA2_Ca	57..937	CDD:130585	342/1003 (34%)
SERCA	NP_726381.1	P-type_ATPase_SERCA	5..989	CDD:319778	341/1001 (34%)