DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FOXB1 and FoxK

DIOPT Version :9

Sequence 1:	NP_036314.2	Gene:	FOXB1 / 27023	HGNCID:	3799	Length:	325	Species:	Homo sapiens
Sequence 2:	NP_001261701.1	Gene:	FoxK / 39252	FlyBaseID:	FBgn0036134	Length:	760	Species:	Drosophila melanogaster

Alignment Length:	253	Identity:	83/253 - (32%)
Similarity:	120/253 - (47%)	Gaps:	37/253 - (14%)

- Green bases have known domain annotations that are detailed below.

Human     4 PGRNTYS-DQKPPYSYISLTAMAIQSSPEKMLPLSEIYKFIMDRFPYYRENTQR-WQNSLRHNLS 66
            |...:|: ::||||||..|...||.::|:|.|.||.||.||:..:||||:.|.: ||||:|||||
  Fly   443 PSTASYNHNEKPPYSYAQLIVQAISAAPDKQLTLSGIYSFIVKHYPYYRKETNKGWQNSIRHNLS 507

Human    67 FNDCFIKIPRRPDQPGKGSFWALHPSCGDMFENGSFLRRRKR--------FKVLKSDHLAPSKPA 123
            .|..|||:.|..|:|||||||.:.|..|....:.|:.:||:|        :.:.:|..::||...
  Fly   508 LNRYFIKVARSQDEPGKGSFWRIDPDSGAKLIDHSYKKRRQRSSQGFRPPYGMPRSAPVSPSHMD 572

Human   124 DAAQYLQQQAKLRLSALAASGTHLPQM---PAAAYNLGGVAQPSGFKHPFAIENIIAREYKMPGG 185
            ::.:....|..:..||..:.|..|.|.   |...||.....|....:.....:..::.....
  Fly   573 NSRESSPLQDIVLQSAPGSPGMSLEQRAADPEIIYNSQNAHQQQQQQQQQQQQQTLSNNSNQ--- 634

Human   186 LAFSAMQPVPAAYPLPNQLTTMGSSLGTGWPHVYGSAGMIDSATPISMASGDYSAYGV 243
              :|:..|    |.:.||    .|.:.|...||.|||           |||.....||
  Fly   635 --YSSGSP----YYVTNQ----SSGVATPQTHVEGSA-----------ASGGGGGGGV 671

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FOXB1	NP_036314.2	FH_FOXB2	1..110	CDD:410817	53/115 (46%)
FOXB1	NP_036314.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	284..325
FoxK	NP_001261701.1	FHA	<170..253	CDD:238017
FoxK	NP_001261701.1	Forkhead	453..540	CDD:278670	47/86 (55%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000010
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2114
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.940