DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FOXD3 and FoxK

DIOPT Version :9

Sequence 1:	NP_036315.1	Gene:	FOXD3 / 27022	HGNCID:	3804	Length:	478	Species:	Homo sapiens
Sequence 2:	NP_001261701.1	Gene:	FoxK / 39252	FlyBaseID:	FBgn0036134	Length:	760	Species:	Drosophila melanogaster

Alignment Length:	494	Identity:	126/494 - (25%)
Similarity:	175/494 - (35%)	Gaps:	158/494 - (31%)

- Green bases have known domain annotations that are detailed below.

Human    47 PAGPPELRL---DEADEVPPAAPHHGQPQPPHQQPL---TLPKEAAGAGAGPGGDVGAPEADGCK 105
            |..||...|   .:..:..||  ||..|..|| .||   .|.::...:|:    .|.||.|
  Fly   315 PHHPPAHHLPLQQQQQQQQPA--HHPLPHTPH-HPLHHTALHQQQQRSGS----IVVAPPA---- 368

Human   106 GGVGGEEGGASGGGPG---------------------AGSGSAGGLAPSKPKNSLV--------- 140
               |......:|.|||                     .|:.||....|:.|:...:
  Fly   369 ---GAAAHLIAGDGPGIYSPLKISIPKKEQKSPYLSPTGTISAANSCPASPRQGFIQNQPNNYNN 430

Human   141 ----------------------KPPYSYIALITMAILQSPQKKLTLSGICEFISNRFPYYR-EKF 182
                                  ||||||..||..||..:|.|:||||||..||...:|||| |..
  Fly   431 YGNNNTQDLFQTPSTASYNHNEKPPYSYAQLIVQAISAAPDKQLTLSGIYSFIVKHYPYYRKETN 495

Human   183 PAWQNSIRHNLSLNDCFVKIPREPGNPGKGNYWTLDPQSEDMFDNGSFLRRRKRFKRHQQEHLRE 247
            ..||||||||||||..|:|:.|....||||::|.:||.|.....:.|:.:||:|
  Fly   496 KGWQNSIRHNLSLNRYFIKVARSQDEPGKGSFWRIDPDSGAKLIDHSYKKRRQR----------- 549

Human   248 QTALMMQSFGAYSLAAAAGAAGPYGRPYGLHPAAAAGAYSHPAAAAAAAAAAALQYPYALPPVAP 312
                           ::.|...|||.     |.:|..:.||...:..::            |:..
  Fly   550 ---------------SSQGFRPPYGM-----PRSAPVSPSHMDNSRESS------------PLQD 582

Human   313 VLPPAVPLLPSGELGRKAA----AFGSQLGPGLQLQLNSLGAAAAAAGTAGAAGTTASLIKSEPS 373
            ::..:.|..|...|.::||    .:.||.....|.|...           .....|.|...::.|
  Fly   583 IVLQSAPGSPGMSLEQRAADPEIIYNSQNAHQQQQQQQQ-----------QQQQQTLSNNSNQYS 636

Human   374 ARPSFSIENIIGGGPAAPGGSAVGAGVAGGTGGSG-------------GGSTAQSFLRPPGTV-- 423
            :...:.:.| ...|.|.|.....|:..:||.||.|             ||..:|..|.....|
  Fly   637 SGSPYYVTN-QSSGVATPQTHVEGSAASGGGGGGGVGALLALKRNHVMGGGASQHTLHQQQAVAQ 700

Human   424 -QSAALMATHQPLSLSR----------TTATIAPILSVP 451
             |.:.::....|...|.          ||||.|.:...|
  Fly   701 QQHSEIIYEELPTDYSGHIEASEEECVTTATDATVAKRP 739

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FOXD3	NP_036315.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..136		28/115 (24%)
FOXD3	NP_036315.1	Forkhead	141..227	CDD:278670	48/86 (56%)
FoxK	NP_001261701.1	FHA	<170..253	CDD:238017
FoxK	NP_001261701.1	Forkhead	453..540	CDD:278670	48/86 (56%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1270467at2759
OrthoFinder	1	1.000	-	-		FOG0000010
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2114
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.850