Protein Alignment FOXD3 and FoxL1

DIOPT Version :10

• Sequence 1: NP_036315.1
• Gene: FOXD3 / 27022
• HGNCID: 3804
• Length: 478
• Species: Homo sapiens
• Sequence 2: NP_523912.1
• Gene: FoxL1 / 38471
• FlyBaseID: FBgn0004895
• Length: 365
• Species: Drosophila melanogaster
• Alignment Length: 358
• Identity: 114/358 - (31%)
• Similarity: 143/358 - (39%)
• Gaps: 102/358 - (28%)

Human    99 PEADGCKGGVGGEEGGASGGGPGAGSGSAG-----------------GLAPSKPKNS--LVKPPY 144
            |.|....||.|.|       |...||.|..                 ||..|...||  ..|||:
  Fly    37 PLAPSAVGGAGME-------GLMCGSFSPAFYYQGIDSFLALHNNIWGLPISFLHNSHRPEKPPF 94

Human   145 SYIALITMAILQSPQKKLTLSGICEFISNRFPYYREKFPAWQNSIRHNLSLNDCFVKIPREPG-- 207
            ||||||.|||..:|.::||||||.:||.::||||||....||||||||||||||||||||:..
  Fly    95 SYIALIAMAISSAPNQRLTLSGIYKFIMDKFPYYRENKQGWQNSIRHNLSLNDCFVKIPRDKNTI 159

Human   208 ----NPGKGNYWTLDPQSEDMFDNGSFLRRRKRFKRHQQEHLR-EQTALMMQSFGAYSLAAAAGA 267
                :.|||:||.||..:.|||:.|::.|||.|.:||.....| |:.:....:.|..|.|.....
  Fly   160 EDNDSAGKGSYWMLDSSASDMFEQGNYRRRRTRRQRHCGHPNRYERESGKDSNDGNSSAAEIRSP 224

Human   268 AGPYG--------------------RPY----------------GLHPA---------AAAGAYS 287
            :.|..                    |.|                ||.|.         ..|.:.|
  Fly   225 SEPLSDFDIFCNERPNYSDRITDLHRQYLSVSLGFNSLFNNEARGLRPLPEIRECPDDVDASSSS 289

Human   288 HPAAAAAAAAAAALQYPYALPPVAPVLPPAVPLLPSGELGRKAAAFGSQLGPGLQLQLNSLGAAA 352
            ..|..::......|..|.|..|               .|.|:..:  |...|.|....|.:....
  Fly   290 SKAMQSSMELHEELHSPSAFTP---------------PLNRRETS--SSGAPVLAEAFNGIKDVV 337

Human   353 AAAGTAGAAGTTASLIKSEPSARPSFSIENIIG 385
            .|.|::..|       .|..|....|:|:||||
  Fly   338 DAPGSSPVA-------SSNRSKTTLFTIDNIIG 363

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FOXD3	NP_036315.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..136		13/53 (25%)
		FH_FOXD3	140..236	CDD:410821	61/101 (60%)
FoxL1	NP_523912.1	FH_FOX	89..186	CDD:469596	58/96 (60%)