Protein Alignment DNAI1 and sw

DIOPT Version :10

• Sequence 1: NP_001268357.1
• Gene: DNAI1 / 27019
• HGNCID: 2954
• Length: 703
• Species: Homo sapiens
• Sequence 2: NP_477075.2
• Gene: sw / 44160
• FlyBaseID: FBgn0003654
• Length: 663
• Species: Drosophila melanogaster
• Alignment Length: 649
• Identity: 137/649 - (21%)
• Similarity: 256/649 - (39%)
• Gaps: 142/649 - (21%)

Human   116 DEGRRQHYRDELVAVSYQGSQESVKVISETGNLEEDEEPKELETEPGSQTDVPAAGAAEKVTEEE 180
            |:.:|:...:.|.::......|.:..:|...::..|          .|.|..|.|.....|..:.
  Fly    47 DKDQRKDLDEMLSSLGVAPVSEVLSSLSSVNSMTSD----------NSNTQTPDASLQATVNGQS 101

Human   181 LMTPKQPKERKLTNQFNFSERASQTYNNPVRDRECQTEPPPRTN---------------FSATAN 230
             ...|||        .|.|....|..|.|.::....|:....|:               .|....
  Fly   102 -GGKKQP--------LNLSVYNVQATNIPPKETLVYTKQTQTTSTGGGNGDVLSCHSSPLSGYME 157

Human   231 QW---------EIYDAY--------VEELEKQEKT-------------------------KEKEK 253
            .|         :.||.|        .:|....|::                         |:...
  Fly   158 DWWRPRKAHATDYYDEYNLNPGLEWEDEFTDDEESSLQNLGNGFTSKLPPGYLTHGLPTVKDVAP 222

Human   254 AKTPVAKKSGKMAMRKLTSMESQTDDLIKLSQ--------AAKIMERMVNQNTYDDIAQDFKYYD 310
            |.||:..|......:::..:..:...:|.||:        |.:::||.:::|.  ||..|:....
  Fly   223 AITPLEIKKETEVKKEVNELSEEQKQMIILSENFQRFVVRAGRVIERALSENV--DIYTDYIGGG 285

Human   311 DAADEYRDQVGTLLPLWKFQNDK--AKRLSVTALCWNPKYRDLFAVGYGSYDFMKQS----RGML 369
            |:.:...::....|.|.:...|:  :|...:|::.|:..:.:|..   |||...::|    .|::
  Fly   286 DSEEANDERSHARLSLNRVFYDERWSKNRCITSMDWSTHFPELVV---GSYHNNEESPNEPDGVV 347

Human   370 LLYSLK-NPSFPEYMFSSNSGVMCLDIHVDHPYLVAVGHYDGNVAIYNLKKPHSQPSFCSSAKSG 433
            ::::.| ..|.||.:|...|.||.......:|.|:..|.|.|.:.:::.:.....|...:...:.
  Fly   348 MVWNTKFKKSTPEDVFHCQSAVMSTCFAKFNPNLILGGTYSGQIVLWDNRVQKRTPIQRTPLSAA 412

Human   434 KHSDPVWQVKWQKDDMDQNL-NFFSVSSDGRIVSWTLVKRKLVHIDVIKLKVEGSTTEVPEGLQL 497
            .|:.||:.::...   .||. |..|:||||::.||:|        |:  |.....|.|:.:....
  Fly   413 AHTHPVYCLQMVG---TQNAHNVISISSDGKLCSWSL--------DM--LSQPQDTLELQQRQSK 464

Human   498 HPVGCGTAFDFHKEIDYMFLVGTEEGKIYKCSK-SYSSQFLDTYDAHNMSVDTVS-----WNPYH 556
            .......||..: ||:.: ::|:|:|.:|..|: ...|...:.|:.|...:..:|     .:|..
  Fly   465 AIAITSMAFPAN-EINSL-VMGSEDGYVYSASRHGLRSGVNEVYERHLGPITGISTHYNQLSPDF 527

Human   557 TKVFMSCSSDWTVKIWDHTIKTPMFIYDLNS-AVGDVAWAPYSSTVFAAVTTDGKAHIFDLAINK 620
            ..:|::.|.|||:|:|......|::.::.|| .|.||||:|....:||||...|:..:::|
  Fly   528 GHLFLTSSIDWTIKLWSLKDTKPLYSFEDNSDYVMDVAWSPVHPALFAAVDGSGRLDLWNL---- 588

Human   621 YEAICNQ----PVAA-------KKNRLTHVQFNLIHPIIIVGDDRGHIISLKLSPNLRKMPKEK 673
                 ||    |.|:       ..||::.....| |  :.:||:.|.:....::.||.:..:::
  Fly   589 -----NQDTEVPTASIVVAGAPALNRVSWTPSGL-H--VCIGDEAGKLYVYDVAENLAQPSRDE 644

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DNAI1	NP_001268357.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..54
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	144..174		5/29 (17%)
		WD 1	324..374		12/55 (22%)
		WD40 repeat	339..385	CDD:293791	12/50 (24%)
		WD40	<357..615	CDD:475233	72/270 (27%)
		WD 2	379..417		11/37 (30%)
		WD40 repeat	391..428	CDD:293791	7/36 (19%)
		WD 3	426..469		13/43 (30%)
		WD40 repeat	439..496	CDD:293791	16/57 (28%)
		WD 4	478..530		12/51 (24%)
		WD40 repeat	504..541	CDD:293791	10/37 (27%)
		WD 5	535..574		11/43 (26%)
		WD40 repeat	547..584	CDD:293791	10/41 (24%)
		WD 6	578..616		14/38 (37%)
		WD40 repeat	589..616	CDD:293791	11/26 (42%)
		WD 7	622..662		11/50 (22%)
sw	NP_477075.2	Dynein_IC2	105..135	CDD:463291	9/37 (24%)
		WD40	316..632	CDD:475233	87/345 (25%)
		WD40 repeat	316..365	CDD:293791	13/51 (25%)
		WD40 repeat	371..409	CDD:293791	6/37 (16%)
		WD40 repeat	418..457	CDD:293791	15/51 (29%)
		WD40 repeat	469..555	CDD:293791	22/87 (25%)
		WD40 repeat	561..599	CDD:293791	16/46 (35%)
		WD40 repeat	607..633	CDD:293791	7/28 (25%)