DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ABL2 and smal

DIOPT Version :9

Sequence 1:	NP_009298.1	Gene:	ABL2 / 27	HGNCID:	77	Length:	1182	Species:	Homo sapiens
Sequence 2:	NP_723165.2	Gene:	smal / 5740323	FlyBaseID:	FBgn0085409	Length:	939	Species:	Drosophila melanogaster

Alignment Length:	336	Identity:	76/336 - (22%)
Similarity:	107/336 - (31%)	Gaps:	106/336 - (31%)

- Green bases have known domain annotations that are detailed below.

Human   598 ATENSASSLAPGFIRGAQASSGSPALPRKQRDKSPSSLLEDAKETCFTRDRKGGFFSSFMKKRNA 662
            |..:...::.|.:   .....|..|:|..| |..|||.:...        ..||  ..::..|..
  Fly   596 AVNDLQCNMTPDY---TDVPEGGYAVPHMQ-DYMPSSKMGGG--------APGG--GGYVNVRRT 646

Human   663 PTPPKRSSSFREMENQP----HKKYELTGNFSSVASLQHADGFSFTPAQQEANLVPPKCYGGSFA 723
            | ||..||.|......|    .|.|..|..|.                       |.|   |..:
  Fly   647 P-PPPLSSIFPRPPTVPPPPMEKYYATTAIFK-----------------------PLK---GPGS 684

Human   724 QRNLCNDD-----GGGGGGS-------GTAGGGWSGITGFFTPRLIKKTLGLRAGKPTASDDTSK 776
            :|:.|:.:     .|||..|       .|.|...|||        ....:|....|.||  ....
  Fly   685 ERSGCSSNTNTVSSGGGKSSHSHSSHCSTGGPDHSGI--------YDDGIGTMNSKATA--PMIN 739

Human   777 PFPRSNSTSSMSSGLPEQDRMAMTLPRNCQRSKLQLERTVSTSSQPEENVDRANDMLPKKSEESA 841
            |:...||:|:.::...|                .|..||.:..|.|:.. ..|:..|     .:|
  Fly   740 PYSSGNSSSAAAAAAAE----------------FQRARTYNFRSYPDNLXFEASLKL-----VAA 783

Human   842 APSRERPKAKLLPRGATALPLRTPSGDLAITEKDPPGVGVAGVAAAPK-------GKEKNGGARL 899
            ||  :|..|.....|:|.:| :.|. .|::......|.| .|.::.||       .|...||..|
  Fly   784 AP--KRITAATASAGSTTMP-KKPQ-HLSLVASTAGGYG-CGTSSKPKYSLTLHNSKLATGGKHL 843

Human   900 GMAGVPEDGEQ 910
                  .||.|
  Fly   844 ------RDGLQ 848

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ABL2	NP_009298.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..47
		CAP	2..106
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	60..80
		SH3_Abl	111..164	CDD:212784
		SH2_ABL	169..262	CDD:198189
		PTKc_Abl	281..543	CDD:270645
		Pkinase_Tyr	288..539	CDD:285015
		Kinase activation loop. /evidence=ECO:0000250	427..451
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	611..641		8/29 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	654..674		7/19 (37%)
		Nuclear localization signal. /evidence=ECO:0000255	658..660		0/1 (0%)
		F-actin-binding. /evidence=ECO:0000250	694..930		52/236 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	763..794		7/30 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	807..851		11/43 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	964..1024
		F-actin-binding. /evidence=ECO:0000250	1020..1182
		FABD	1063..1182	CDD:197885
smal	NP_723165.2	FA58C	78..234	CDD:214572
smal	NP_723165.2	FA58C	81..233	CDD:238014
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910