Protein Alignment ABL2 and abl2

DIOPT Version :10

• Sequence 1: NP_009298.1
• Gene: ABL2 / 27
• HGNCID: 77
• Length: 1182
• Species: Homo sapiens
• Sequence 2: XP_005166946.1
• Gene: abl2 / 570636
• ZFINID: ZDB-GENE-020809-2
• Length: 1182
• Species: Danio rerio
• Alignment Length: 1250
• Identity: 830/1250 - (66%)
• Similarity: 926/1250 - (74%)
• Gaps: 136/1250 - (10%)

Human     1 MGQQVGRVGE--APGLQ-QPQPRGIRG-SSAARPSGRR-RD--------------PAGRTT---- 42
            ||||||||||  :.|:| |||.:..:| |:.|..|||| ||              |.||:.
Zfish     1 MGQQVGRVGEGASSGIQTQPQSQQQQGRSNRASSSGRRPRDGGGGGSSTLTLTGTPPGRSAAAAV 65

Human    43 ----ETGFNIFTQHDHFASCVEDGFEGDKTGGSSPEALHRPYGCDVEPQALNEAIRWSSKENLLG 103
                :.|.|:||.|.                    ||||||:|.|  ..||.||:||||||||||
Zfish    66 NIMPDPGINVFTLHS--------------------EALHRPFGLD--STALTEAVRWSSKENLLG 108

Human   104 ATESDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQGWVPSNYITPVNSL 168
            |.|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Zfish   109 AAESDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQGWVPSNYITPVNSL 173

Human   169 EKHSWYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTADGKVYVT 233
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||||.:|||||||
Zfish   174 EKHSWYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTASDGKVYVT 238

Human   234 AESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQ 298
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Zfish   239 AESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQ 303

Human   299 YGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEY 363
            ||||||||||||:||||||||||||||||||||||:||||:||||||||||||||||||||||||
Zfish   304 YGEVYVGVWKKYNLTVAVKTLKEDTMEVEEFLKEASVMKEVKHPNLVQLLGVCTLEPPFYIVTEY 368

Human   364 MPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADF 428
            ||:||||||||||.|::|.||||||||||||||||||||||||||||||||||||||||||||||
Zfish   369 MPHGNLLDYLRECERDQVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADF 433

Human   429 GLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQ 493
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Zfish   434 GLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQ 498

Human   494 VYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFETMFHDSSISEEVAEELGR 558
            |||||||||||||||||||||||||||||:|||.|||||||.|||||||||||||||||||||.:
Zfish   499 VYDLLEKGYRMEQPEGCPPKVYELMRACWQWSPLDRPSFAEIHQAFETMFHDSSISEEVAEELCK 563

Human   559 AAS---SSSVVPYLPRLPILPSKTRTLKKQVENKENIEGAQDATENSASSLAPGFIRGAQASSGS 620
            .||   |.....:.|.:|:||||:|..||..|||||:|   :|..:..:.||.....|...||.|
Zfish   564 TASGGQSGVAHTFGPDMPLLPSKSRGQKKHSENKENME---EAGPHGPAGLATSLFVGDGRSSSS 625

Human   621 PALPRKQRDKSPSSLLEDAKETCFTRDRKGGFFSSFMKKR---------------NAPTPPKRSS 670
            ||||||||||||||||||.::|.||||||.|||||||||:               |.|.||||||
Zfish   626 PALPRKQRDKSPSSLLEDCQDTTFTRDRKAGFFSSFMKKKSMSSSSATSSPQQQQNLPMPPKRSS 690

Human   671 SFREMENQPHKKYELTGNFSS-VASLQHADGFSFTPAQQEANLVPPKCYGGSFAQRNLCNDDGGG 734
            ||||||.|||||||.|..||. ...|...||.||:|:..|.|.|..:|.|.:|.|:...::.|..
Zfish   691 SFREMETQPHKKYEPTAGFSGPPPPLPQTDGLSFSPSHGEGNHVQSRCCGATFGQKPSSSNSGAT 755

Human   735 GGGSGTAGGGWSGITGFFTPRLIKKTLGLRAGKPTASDDTS--KPFPRSNSTSSMSSGLPEQDRM 797
            .|..|:: ..|..:.|||||||||||||||.||.:..|:.|  |||||||||||||:|||:.:||
Zfish   756 SGQVGSS-SSWGSLAGFFTPRLIKKTLGLRTGKSSGIDEVSGAKPFPRSNSTSSMSAGLPDLERM 819

Human   798 AMTLPRNCQRSKLQLERTVSTSSQPEENVDRANDMLPKKSEESAAPSRERPKAKLLPRGATALPL 862
            |:|||||  |||..||||.||:||||....|.:|.:.:|.:|..|..|:|||||||||| .|..:
Zfish   820 ALTLPRN--RSKPPLERTSSTTSQPENGATRPSDAILRKLDEGTAQIRDRPKAKLLPRG-VAGGV 881

Human   863 RTPSGDLAITEKDPPGVGVAGVAAAPKGKEKNGGARLGMAGVPEDGEQPGWPSPAKAAPV-LPTT 926
            |.|              ||.|.|      |.:...|    |.....::.||.||:|.:.: ....
Zfish   882 RAP--------------GVGGEA------ESDSNTR----GKDGQDDRQGWSSPSKTSTLGSVNL 922

Human   927 HNHKVPVLISPTLKHTPADVQLIGTDSQGNKFKLLSEHQVTSSGDKDRPRRVKPKCAPPPPPVMR 991
            |||||||||||||||:..|..|:|.|||||:|||||:     |||:||||.|||||||||||::|
Zfish   923 HNHKVPVLISPTLKHSSGDAHLVGVDSQGNRFKLLSD-----SGDRDRPRLVKPKCAPPPPPMLR 982

Human   992 LLQHPSICSDPTEEPTALTAGQSTSETQEGGKKAALGAVPISGKAGRPVMPPPQVP----LPTS- 1051
            .||| :..:|..:|..:.....:....:..|::.         :..||.:||||||    :|:|
Zfish   983 SLQH-AYSADAADEVVSGNMEVNGDTIKRSGREV---------RGARPSIPPPQVPPAPVVPSSN 1037

Human  1052 SISPAKMANGTA-------GTKVALRKTKQAAEKISADKISKEALLECADLLSSAL---TEPVPN 1106
            :.:..|:|||.:       ..|..||:|:|..|:|..:|||||||||||:.|||||   :|...:
Zfish  1038 NTTQTKLANGASSGGPGPTSAKPTLRRTRQQTERIPLEKISKEALLECAECLSSALQGNSELSSS 1102

Human  1107 SQLVDTGHQLLDYCSGYVDCIPQTRNKFAFREAVSKLELSLQELQVSSAAAGV----PGTNPVLN 1167
            ||::|.||||||||||||||||||||||||||||.|||||||||:..|...||    |||:|.|:
Zfish  1103 SQVLDVGHQLLDYCSGYVDCIPQTRNKFAFREAVGKLELSLQELRACSTGGGVGLSGPGTSPALD 1167

Human  1168 NLLSCVQEISDVVQR 1182
            ||..|::||||||||
Zfish  1168 NLHMCIKEISDVVQR 1182

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ABL2	NP_009298.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..47		28/72 (39%)
		CAP	2..106		54/130 (42%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	60..80		5/19 (26%)
		SH3_Abl	111..164	CDD:212784	52/52 (100%)
		SH2_ABL	169..262	CDD:198189	90/92 (98%)
		PTKc_Abl	281..543	CDD:270645	250/261 (96%)
		Kinase activation loop. /evidence=ECO:0000250	427..451		23/23 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	611..641		22/29 (76%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	654..674		16/34 (47%)
		Nuclear localization signal. /evidence=ECO:0000255	658..660		1/1 (100%)
		F-actin-binding. /evidence=ECO:0000250	694..930		106/238 (45%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	763..794		22/32 (69%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	807..851		22/43 (51%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	964..1024		25/59 (42%)
		F-actin-binding. /evidence=ECO:0000250	1020..1182		96/180 (53%)
		FABD	1063..1182	CDD:197885	81/132 (61%)
abl2	XP_005166946.1	SH3_Abl	116..169	CDD:212784	52/52 (100%)
		SH2_ABL	174..267	CDD:198189	90/92 (98%)
		PTKc_Abl	286..548	CDD:270645	250/261 (96%)
		FABD	1057..1182	CDD:197885	81/124 (65%)