DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ABL2 and Src64B

DIOPT Version :9

Sequence 1:	NP_009298.1	Gene:	ABL2 / 27	HGNCID:	77	Length:	1182	Species:	Homo sapiens
Sequence 2:	NP_001286937.1	Gene:	Src64B / 48973	FlyBaseID:	FBgn0262733	Length:	553	Species:	Drosophila melanogaster

Alignment Length:	452	Identity:	191/452 - (42%)
Similarity:	278/452 - (61%)	Gaps:	18/452 - (3%)

- Green bases have known domain annotations that are detailed below.

Human   113 VALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVR-SKNGQGWVPSNYITPVNSLEKHSWYHG 176
            |||||:.:..::.||..||:::.|:...::..|..|. :...:|.:|.|::....|:....|:..
  Fly   101 VALYDYKSRDESDLSFMKGDRMEVIDDTESDWWRVVNLTTRQEGLIPLNFVAEERSVNSEDWFFE 165

Human   177 PVSRSAAEYLLSSLIN--GSFLVRESESSPGQLSISLR--YEGRVY---HYRINTTADGKVYVTA 234
            .|.|..|:.||.:..|  |:||||.||.:|...|:|::  .:||.|   ||||....:|..|:..
  Fly   166 NVLRKEADKLLLAEENPRGTFLVRPSEHNPNGYSLSVKDWEDGRGYHVKHYRIKPLDNGGYYIAT 230

Human   235 ESRFSTLAELVHHHSTV-ADGLVTTLHYPAPKCNKPTVYGVSP-IHDKWEMERTDITMKHKLGGG 297
            ...|.:|..||..:|.. |.||...|..|.|| .:|.::.:.| :.||:|:.|::|.:..|||.|
  Fly   231 NQTFPSLQALVMAYSKENALGLCHILSRPCPK-PQPQMWDLGPELRDKYEIPRSEIQLLRKLGRG 294

Human   298 QYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTE 362
            .:|||:.|.|:. |:.||||||:|.||....||:|||:||:.:|..||.|..||:.|.|.|||.|
  Fly   295 NFGEVFYGKWRN-SIDVAVKTLREGTMSTAAFLQEAAIMKKFRHNRLVALYAVCSQEEPIYIVQE 358

Human   363 YMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVAD 427
            ||..|:|||:|||.:...:....|:|:|||::|.|||||.|..|||||||||.|:|||:|.|:.|
  Fly   359 YMSKGSLLDFLREGDGRYLHFEDLIYIATQVASGMEYLESKQLIHRDLAARNVLIGENNVAKICD 423

Human   428 FGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLS 492
            |||:|::..|.|....|::||:||||||::.|..||||||||::|:||.|:.|||..||||:...
  Fly   424 FGLARVIADDEYCPKQGSRFPVKWTAPEAIIYGKFSIKSDVWSYGILLMELFTYGQVPYPGMHSR 488

Human   493 QVYDLLEKGYRMEQPEG--CPPKVYELMRACWKWSPADRPSFAETHQAFETMFHDSSISEEV 552
            :|.:.:|:|:||.:|..  .|..:|:|:..||...|..||:|...:..||:.    |::.||
  Fly   489 EVIENIERGFRMPKPTNHYFPDNIYQLLLQCWDAVPEKRPTFEFLNHYFESF----SVTSEV 546

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ABL2	NP_009298.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..47
		CAP	2..106
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	60..80
		SH3_Abl	111..164	CDD:212784	15/51 (29%)
		SH2_ABL	169..262	CDD:198189	35/100 (35%)
		PTKc_Abl	281..543	CDD:270645	130/263 (49%)
		Pkinase_Tyr	288..539	CDD:285015	126/252 (50%)
		Kinase activation loop. /evidence=ECO:0000250	427..451		10/23 (43%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	611..641
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	654..674
		Nuclear localization signal. /evidence=ECO:0000255	658..660
		F-actin-binding. /evidence=ECO:0000250	694..930
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	763..794
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	807..851
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	964..1024
		F-actin-binding. /evidence=ECO:0000250	1020..1182
		FABD	1063..1182	CDD:197885
Src64B	NP_001286937.1	SH3_Src_like	99..150	CDD:212779	14/48 (29%)
		SH2_Src_family	158..259	CDD:199827	35/100 (35%)
		STYKc	285..537	CDD:214568	126/252 (50%)
		PTKc_Src_like	289..538	CDD:270630	125/249 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X88
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910