DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ABL2 and csw

DIOPT Version :9

Sequence 1:	NP_009298.1	Gene:	ABL2 / 27	HGNCID:	77	Length:	1182	Species:	Homo sapiens
Sequence 2:	NP_477131.1	Gene:	csw / 45278	FlyBaseID:	FBgn0000382	Length:	945	Species:	Drosophila melanogaster

Alignment Length:	698	Identity:	135/698 - (19%)
Similarity:	226/698 - (32%)	Gaps:	264/698 - (37%)

- Green bases have known domain annotations that are detailed below.

Human    10 EAPGLQQPQPRG----------IRGSSAARPSGRRRDPAGRTTETGFNIFTQHDHFASCVEDGFE 64
            |.|..|:|..:.          |:|.:....:.|.||  .|.......:..|....||
  Fly    94 ETPEAQEPACKNCMTHDELAQIIKGVAKGADAQRNRD--NRLQRRRRPLSAQPSAAAS------- 149

Human    65 GDKTGGSSPEALHRPYGCDVEPQALNEA--IRWSSKENLLGATESDPNLFVALYDFVASGDNTLS 127
                ..:|.|:|||   ....|||...|  ..|:          :.|..|.|.:...:..::|||
  Fly   150 ----ASTSTESLHR---LTPSPQASYPATPTSWT----------ATPPQFPAAFGGASCSNSTLS 197

Human   128 ITKGEKLRVLGYNQNGEWSEVRSKNGQGWVPSNYITPVNSLEKHSWYHGPVSRSAAEYL-LSSLI 191
            :....::::.||                                :|:||.:|...||.| |....
  Fly   198 LLATMRVQLHGY--------------------------------TWFHGNLSGKEAEKLILERGK 230

Human   192 NGSFLVRESESSPGQLSISLRYEGRVYHYRINTTADGKVYVTAESRFSTLAELVHHH--STVADG 254
            |||||||||:|.||...:|:|.:.:|.|..|. ..|.|..|.....|.||:||:.|:  :.:.:.
  Fly   231 NGSFLVRESQSKPGDFVLSVRTDDKVTHVMIR-WQDKKYDVGGGESFGTLSELIDHYKRNPMVET 294

Human   255 LVTTLHYPAP-KCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKT 318
            ..|.:|...| ...:.|..|::        .|.:..:|.            |.|:::      ::
  Fly   295 CGTVVHLRQPFNATRITAAGIN--------ARVEQLVKG------------GFWEEF------ES 333

Human   319 LKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTA 383
            |::|:.:.  |.:.....:|.:..|                     .|.|:|.|       :.|.
  Fly   334 LQQDSRDT--FSRNEGYKQENRLKN---------------------RYRNILPY-------DHTR 368

Human   384 VVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMT-GDTYTAHAGAKF 447
            |.||.:...::.| ||: ..|:|                         ||.| ||.|
  Fly   369 VKLLDVEHSVAGA-EYI-NANYI-------------------------RLPTDGDLY-------- 398

Human   448 PIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPP 512
                    :::.::.|:.|.|                                       ..||
  Fly   399 --------NMSSSSESLNSSV---------------------------------------PSCP- 415

Human   513 KVYELMRACWKWSPADRPSFAETHQAFETMFHDSSISEEVAEELGRAASSSSVVPYLPRLPILPS 577
                   ||         :.|:|.:       :.|..:...:...:.|..|:::|| ........
  Fly   416 -------AC---------TAAQTQR-------NCSNCQLQNKTCVQCAVKSAILPY-SNCATCSR 456

Human   578 KTRTLKKQVENKENIEGAQDATENSASSLAPGFIRGAQASSGSPALPRKQRDKSPSSLLEDAKET 642
            |:.:|.|.    :..|.:..::.:|.|...||       |||:..:.......:|::|....
  Fly   457 KSDSLSKH----KRSESSASSSPSSGSGSGPG-------SSGTSGVSSVNGPGTPTNLTSGT--- 507

Human   643 CFTRDRKGGFFSSFMKKRNAPTPPKRSSSF----REMENQPHKKYELT 686
                   .|.....:|:.:..:....|.|.    ||.|.:..|.|..|
  Fly   508 -------AGCLVGLLKRHSNDSSGAVSISMAEREREREREMFKTYIAT 548

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ABL2	NP_009298.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..47		10/46 (22%)
		CAP	2..106		23/107 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	60..80		5/19 (26%)
		SH3_Abl	111..164	CDD:212784	7/52 (13%)
		SH2_ABL	169..262	CDD:198189	36/95 (38%)
		PTKc_Abl	281..543	CDD:270645	37/262 (14%)
		Pkinase_Tyr	288..539	CDD:285015	36/251 (14%)
		Kinase activation loop. /evidence=ECO:0000250	427..451		6/24 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	611..641		5/29 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	654..674		3/23 (13%)
		Nuclear localization signal. /evidence=ECO:0000255	658..660		1/1 (100%)
		F-actin-binding. /evidence=ECO:0000250	694..930
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	763..794
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	807..851
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	964..1024
		F-actin-binding. /evidence=ECO:0000250	1020..1182
		FABD	1063..1182	CDD:197885
csw	NP_477131.1	SH2_C-SH2_SHP_like	211..307	CDD:198185	37/96 (39%)
		PTPc	326..744	CDD:214550	63/387 (16%)
		PTPc	543..743	CDD:238006	3/6 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910