DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ABL2 and Shark

DIOPT Version :9

Sequence 1:	NP_009298.1	Gene:	ABL2 / 27	HGNCID:	77	Length:	1182	Species:	Homo sapiens
Sequence 2:	NP_524743.2	Gene:	Shark / 44353	FlyBaseID:	FBgn0015295	Length:	939	Species:	Drosophila melanogaster

Alignment Length:	497	Identity:	140/497 - (28%)
Similarity:	220/497 - (44%)	Gaps:	108/497 - (21%)

- Green bases have known domain annotations that are detailed below.

Human   126 LSITKGEKLRVLGYNQNGEWSEVRSKNGQGWVPSNYITPVNSLEKHSWYHGPVSRSAAEYLLSSL 190
            |:|||.::..    |.:..::.:|..:     |...:..:|||.|:.   ....||.:|    |.
  Fly   450 LTITKKKQKE----NSSSMFNTLRLTS-----PKKALFDMNSLRKNK---SKGKRSDSE----SS 498

Human   191 INGSFLVRESE---SSPGQLSISLRYE-----------------GRVYHYRINTT---------- 225
            ::||....|.|   ::|...|:|...|                 |.||:...|.|
  Fly   499 VSGSLAGTEQELQAAAPMLKSLSFSTEFSTFNADGVTGSGAAAAGEVYNVPRNNTPIEIDLPPIA 563

Human   226 ---------------------------------------ADGKVYVTAESRFSTLAELVHHHSTV 251
                                                   .|.::...|.:|.::|.......|.:
  Fly   564 QKTEAEVEYFTKSDVAIERERAGQWIGNGYQPTMDVLSLLDQQIKAPAVARLNSLGPNASTESEM 628

Human   252 ADGLVTTLHYPAPKC----NKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVW----- 307
            |.       |...||    :.|:...|.....::.:|...:.:..::|.|::|.|:.| |
  Fly   629 AS-------YLHRKCSGTPSTPSATEVEAAKLRFFIEPEKLVLDREIGHGEFGSVHSG-WLLRKS 685

Human   308 ---KKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNL 369
               ::..|.||:|.|.::....:|||:||:||..::|..:|:|:|:...| ...:|.|..|.|::
  Fly   686 GAGEESRLEVAIKMLSDEHSNKQEFLREASVMMRLEHKCIVRLIGIAKGE-MLMMVQELAPLGSM 749

Human   370 LDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSR-L 433
            |.|:.:...|......|...|:||:..|.|||.::|:||||||||.|:...|..|::|||:|| |
  Fly   750 LQYILDHGHEITANAELKVWASQIACGMHYLESQHFVHRDLAARNILLTARHQAKISDFGMSRSL 814

Human   434 MTGDT-YTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDL 497
            ..|.| |....|.::||:|.||||.....||..||||:|||.:||:.:.|..||..|.......|
  Fly   815 RPGSTEYQFTQGGRWPIRWYAPESFNLGIFSHASDVWSFGVTIWEMFSLGAPPYGEISNVDAIKL 879

Human   498 LEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAF 539
            ::.|.|:.||..||..:|.:|::|||..|.|||:|....:.|
  Fly   880 VDSGERLPQPNLCPAYIYAVMQSCWKERPKDRPTFVYLTEFF 921

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ABL2	NP_009298.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..47
		CAP	2..106
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	60..80
		SH3_Abl	111..164	CDD:212784	7/37 (19%)
		SH2_ABL	169..262	CDD:198189	24/161 (15%)
		PTKc_Abl	281..543	CDD:270645	101/269 (38%)
		Pkinase_Tyr	288..539	CDD:285015	99/260 (38%)
		Kinase activation loop. /evidence=ECO:0000250	427..451		12/25 (48%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	611..641
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	654..674
		Nuclear localization signal. /evidence=ECO:0000255	658..660
		F-actin-binding. /evidence=ECO:0000250	694..930
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	763..794
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	807..851
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	964..1024
		F-actin-binding. /evidence=ECO:0000250	1020..1182
		FABD	1063..1182	CDD:197885
Shark	NP_524743.2	SH2_Nterm_shark_like	8..91	CDD:198210
		Ank_2	<112..184	CDD:289560
		ANK	117..241	CDD:238125
		ANK repeat	124..151	CDD:293786
		ANK repeat	153..184	CDD:293786
		Ank_2	158..247	CDD:289560
		ANK repeat	186..217	CDD:293786
		ANK repeat	220..245	CDD:293786
		Ank_4	224..274	CDD:290365
		SH2_Cterm_shark_like	287..395	CDD:198211
		TyrKc	662..921	CDD:197581	99/260 (38%)
		PTKc_Syk_like	666..926	CDD:270650	100/258 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910