DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ABL2 and Ret

DIOPT Version :9

Sequence 1:	NP_009298.1	Gene:	ABL2 / 27	HGNCID:	77	Length:	1182	Species:	Homo sapiens
Sequence 2:	NP_477044.1	Gene:	Ret / 43875	FlyBaseID:	FBgn0011829	Length:	1235	Species:	Drosophila melanogaster

Alignment Length:	500	Identity:	155/500 - (31%)
Similarity:	224/500 - (44%)	Gaps:	93/500 - (18%)

- Green bases have known domain annotations that are detailed below.

Human   280 KWEMERTDITMKHKLGGGQYGEVYVGVWKKYS-----LTVAVKTLKEDTMEVE--EFLKEAAVMK 337
            |||..|..:.:...||.|::|:|..|...:.:     .|||||.||:.:..||  ..|.|..:::
  Fly   763 KWEFPREKLQLDTVLGEGEFGQVLKGFATEIAGLPGITTVAVKMLKKGSNSVEYMALLSEFQLLQ 827

Human   338 EIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLR-----EC-------NREEVTAVVLLYMA 390
            |:.|||:::|||.||......::.||..||:|..|||     ||       ..|.|...::|..|
  Fly   828 EVSHPNVIKLLGACTSSEAPLLIIEYARYGSLRSYLRLSRKIECAGVDFADGVEPVNVKMVLTFA 892

Human   391 TQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSR-LMTGDTYTAHAGAKFPIKWTAP 454
            .||...|.||.:...:||||||||.|:.:..:.|::||||:| :...|.|...:..:.|:||.||
  Fly   893 WQICKGMAYLSELKLVHRDLAARNVLLADGKICKISDFGLTRDVYEDDAYLKRSRDRVPVKWMAP 957

Human   455 ESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMR 519
            ||||.:.::.|||||:||||.||:.|.|.||||||....::.||:.||||::||.|...||.::|
  Fly   958 ESLADHVYTSKSDVWSFGVLCWELITLGASPYPGIAPQNLWSLLKTGYRMDRPENCSEAVYSIVR 1022

Human   520 ACWKWSPADRPSFAETHQAFETMF---------------------HDSSISEEVAEELGRAASSS 563
            .||...|..||||......||.:.                     .||::   :..|||...|
  Fly  1023 TCWADEPNGRPSFKFLASEFEKLLGNNAKYIDLETNAVSNPLYCGDDSAL---ITTELGEPES-- 1082

Human   564 SVVPYLPRLPILPSKTRTLKKQVENKENIEGAQDATENSASSLAPGFIRGAQASSGSPALPRKQR 628
                 |..|...|.....:..|..:.:..|.....|    |:..||:           .|||...
  Fly  1083 -----LQHLWSPPKIAYDIHDQATSYDQSEEEMPVT----STAPPGY-----------DLPRPLL 1127

Human   629 DKSPS-SLLEDAKETCFTRD-RKGGFFSSFMKKRNAP----------TPPKRSSSFREMEN---- 677
            |.:.: .:|....:..|..: ||.....|:....:.|          .|.||..|:.:|.|
  Fly  1128 DATANGQVLRYENDLRFPLNIRKSSCTPSYSNMTSEPPATTSLPHYSVPVKRGRSYLDMTNKSLI 1192

Human   678 ---------QPHKKYELTGNFSSVASLQHADGFSFTPAQQEANLV 713
                     :.|....::..|||:.:|......|  |..|..:.|
  Fly  1193 PDNLDSREFEKHLSKTISFRFSSLLNLSETKEVS--PGWQAEDAV 1235

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ABL2	NP_009298.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..47
		CAP	2..106
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	60..80
		SH3_Abl	111..164	CDD:212784
		SH2_ABL	169..262	CDD:198189
		PTKc_Abl	281..543	CDD:270645	114/281 (41%)
		Pkinase_Tyr	288..539	CDD:285015	109/270 (40%)
		Kinase activation loop. /evidence=ECO:0000250	427..451		8/24 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	611..641		5/30 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	654..674		6/29 (21%)
		Nuclear localization signal. /evidence=ECO:0000255	658..660		0/1 (0%)
		F-actin-binding. /evidence=ECO:0000250	694..930		4/19 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	763..794
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	807..851
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	964..1024
		F-actin-binding. /evidence=ECO:0000250	1020..1182
		FABD	1063..1182	CDD:197885
Ret	NP_477044.1	PKc_like	770..1049	CDD:304357	111/278 (40%)
Ret	NP_477044.1	TyrKc	771..1042	CDD:197581	109/270 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910