DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ABL2 and Eph

DIOPT Version :9

Sequence 1:	NP_009298.1	Gene:	ABL2 / 27	HGNCID:	77	Length:	1182	Species:	Homo sapiens
Sequence 2:	NP_524625.3	Gene:	Eph / 43803	FlyBaseID:	FBgn0025936	Length:	1096	Species:	Drosophila melanogaster

Alignment Length:	529	Identity:	157/529 - (29%)
Similarity:	228/529 - (43%)	Gaps:	103/529 - (19%)

- Green bases have known domain annotations that are detailed below.

Human    93 IRWSSKENLLGATESDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWS-EVRSKNGQGW 156
            :||..|..|....:|..|                  ||..|..::|..:|.|:. :||.|...|:
  Fly   566 VRWFPKVELDAINKSALN------------------TKETKAHIVGLLENTEYGFQVRCKTNNGF 612

Human   157 VP-SNYITPVNSLEKHSWYHGPVSRSAAEYLLSSLING-SFLV----------RE------SESS 203
            .. ||.|.........|.|...|.   ..::..:::.| .|||          |.      .:.|
  Fly   613 GSYSNMIYAQTLQSVGSVYDDSVQ---IRFIAGAIVTGVLFLVIFIIATVYFMRSKHQDDLDKKS 674

Human   204 PGQLSISLRYEGRVYHYRINTTADGKVYVTAES-RFSTLAELVHHHSTVADGLVTTLHYPAPKCN 267
            ...|.:.|.|.....:....|....|:::...: .|......|..|:           |..|.
  Fly   675 TNHLPLPLDYASNEVNSMDTTPIVKKLHLNVTTPLFGNSRSYVDPHT-----------YEDPN-- 726

Human   268 KPTVYGVSPIHD-KWEMERTDITMKHKLGGGQYGEVYVGVWK-----KYSLTVAVKTLKEDTMEV 326
                   ..|.: ..|::...||::..:|||::|:|..|..|     ...:.||:||||..:.|.
  Fly   727 -------QAIREFAREIDANYITIEAIIGGGEFGDVCRGRLKIPPNFVQDIDVAIKTLKPGSSEK 784

Human   327 E--EFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYM 389
            .  :||.||::|.:..|||::.|.||.|...|..|:||||..|:|..:|| .|..:...:.|:.|
  Fly   785 ARCDFLTEASIMGQFDHPNVIYLQGVVTRSNPVMIITEYMENGSLDTFLR-VNDGKFQTLQLIVM 848

Human   390 ATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLM--TGDTYTAHAGAKFPIKWT 452
            ...|:|.|.||...|::||||||||.||....:.|:|||||||.:  ..|.||.. |.|.|::||
  Fly   849 LRGIASGMSYLSDMNYVHRDLAARNVLVNAQLICKIADFGLSREIENASDAYTTR-GGKIPVRWT 912

Human   453 APESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYEL 517
            |||::|:..|:..||||::||:|||:.:||..||.......|...:|||||:..|..||..:|:|
  Fly   913 APEAIAFRKFTSASDVWSYGVVLWEVMSYGERPYWNWSNQDVIKSIEKGYRLPAPMDCPEALYQL 977

Human   518 MRACWKWSPADRPSFAETHQAFETMFHDSSISEEVAEELGRAASSSSVVPYLPRLPILPSKTRTL 582
            |..||:.....||:||                              |:|..|..|...|....|.
  Fly   978 MLDCWQKQRTHRPTFA------------------------------SIVSTLDNLARQPQSLLTT 1012

Human   583 KKQVENKEN 591
            :...|:..|
  Fly  1013 RPSPESDGN 1021

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ABL2	NP_009298.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..47
		CAP	2..106		4/12 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	60..80
		SH3_Abl	111..164	CDD:212784	13/54 (24%)
		SH2_ABL	169..262	CDD:198189	17/110 (15%)
		PTKc_Abl	281..543	CDD:270645	110/270 (41%)
		Pkinase_Tyr	288..539	CDD:285015	109/259 (42%)
		Kinase activation loop. /evidence=ECO:0000250	427..451		12/25 (48%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	611..641
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	654..674
		Nuclear localization signal. /evidence=ECO:0000255	658..660
		F-actin-binding. /evidence=ECO:0000250	694..930
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	763..794
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	807..851
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	964..1024
		F-actin-binding. /evidence=ECO:0000250	1020..1182
		FABD	1063..1182	CDD:197885
Eph	NP_524625.3	EphR_LBD	85..260	CDD:198439
		FN3	387..476	CDD:238020
		FN3	536..623	CDD:238020	19/74 (26%)
		EphA2_TM	644..736	CDD:291255	17/111 (15%)
		PTKc_EphR	736..1002	CDD:270629	112/297 (38%)
		Pkinase_Tyr	741..999	CDD:285015	111/289 (38%)
		SAM_1	1033..1092	CDD:278937
		SAM	1039..1092	CDD:197735
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910