DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ABL2 and Crk

DIOPT Version :9

Sequence 1:	NP_009298.1	Gene:	ABL2 / 27	HGNCID:	77	Length:	1182	Species:	Homo sapiens
Sequence 2:	NP_651908.1	Gene:	Crk / 43775	FlyBaseID:	FBgn0024811	Length:	271	Species:	Drosophila melanogaster

Alignment Length:	222	Identity:	54/222 - (24%)
Similarity:	87/222 - (39%)	Gaps:	63/222 - (28%)

- Green bases have known domain annotations that are detailed below.

Human   169 EKHSWYHGPVSR-SAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTT--ADGKV 230
            :::|||.||:|| .|.|.|::....|.||||:|.|..|...:.:|.:.:|.:|.||..  .|..|
  Fly     8 DRNSWYFGPMSRQDATEVLMNERERGVFLVRDSNSIAGDYVLCVREDTKVSNYIINKVQQQDQIV 72

Human   231 YVTAESRFSTLAELVHHHSTVADGLVTTLHY------PAPKCNKPTVYGVSPIHDKWEMERTD-- 287
            |...:..|..|.:|:..:         ||||      ..|.|.:     |..:..|::...:|
  Fly    73 YRIGDQSFDNLPKLLTFY---------TLHYLDTTPLKRPACRR-----VEKVIGKFDFVGSDQD 123

Human   288 ---------ITMKHK---------LGGGQYGEVYVGVWKKY------------------SLTVAV 316
                     :|:..|         ...|:.|::.|...::|                  |..|..
  Fly   124 DLPFQRGEVLTIVRKDEDQWWTARNSSGKIGQIPVPYIQQYDDYMDEDAIDKNEPSISGSSNVFE 188

Human   317 KTLKEDTMEVEEFLKEAAVMKEIKHPN 343
            .|||.  .::...|...|.:|:.:.||
  Fly   189 STLKR--TDLNRKLPAYARVKQSRVPN 213

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ABL2	NP_009298.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..47
		CAP	2..106
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	60..80
		SH3_Abl	111..164	CDD:212784
		SH2_ABL	169..262	CDD:198189	33/101 (33%)
		PTKc_Abl	281..543	CDD:270645	17/101 (17%)
		Pkinase_Tyr	288..539	CDD:285015	16/83 (19%)
		Kinase activation loop. /evidence=ECO:0000250	427..451
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	611..641
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	654..674
		Nuclear localization signal. /evidence=ECO:0000255	658..660
		F-actin-binding. /evidence=ECO:0000250	694..930
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	763..794
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	807..851
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	964..1024
		F-actin-binding. /evidence=ECO:0000250	1020..1182
		FABD	1063..1182	CDD:197885
Crk	NP_651908.1	SH2_CRK_like	4..108	CDD:198180	35/113 (31%)
		SH3_CRK_N	109..163	CDD:212692	7/53 (13%)
		SH3_CRK_C	201..257	CDD:212693	4/13 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910