DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ABL2 and cindr

DIOPT Version :9

Sequence 1:	NP_009298.1	Gene:	ABL2 / 27	HGNCID:	77	Length:	1182	Species:	Homo sapiens
Sequence 2:	NP_001263129.1	Gene:	cindr / 43654	FlyBaseID:	FBgn0027598	Length:	941	Species:	Drosophila melanogaster

Alignment Length:	838	Identity:	166/838 - (19%)
Similarity:	267/838 - (31%)	Gaps:	291/838 - (34%)

- Green bases have known domain annotations that are detailed below.

Human   531 SFAETHQAFETMFHDSSISEEVAEEL------GRAA--SSSSVVPYLP----------RLPILPS 577
            |.:.|.||.::....::.:...||..      |.||  .:::.||.||          ..|..|.
  Fly   203 STSTTKQATKSRATAAAAASAPAEPAAIVSGSGAAAGGGAAAAVPMLPPKPQREFCRVEFPYAPQ 267

Human   578 KTRTLKKQVEN---------------KENIEGAQDA-TENSASSLAPGFIRGAQASSGSPALPRK 626
            ....|:.:|::               |..|.|.... .:|....|||      ..::.:|.|||.
  Fly   268 NDDELELKVDDIIAVISTELPDKGWWKGEIRGKVGVFPDNFVKMLAP------SEATAAPPLPRP 326

Human   627 QRDKSP----------SSLLEDAKETCFTRDRKGGFF-------SSFMKKRNAP--TPPKR---S 669
            :....|          |.:::..:..  .|.::||.|       :||:....||  .||..   :
  Fly   327 RPRTRPGMGGTGAGSGSGIIDGVRTP--RRTQRGGSFEFLGARMASFITTIFAPINEPPSATQIT 389

Human   670 SSFREMENQPHKKYELTGNFSSVASLQHADGFSFTPAQQEANLVPPKCYGGSFAQRNLCNDDGGG 734
            .:.|::.|.......:|...||.:|..     |.|..||:..:
  Fly   390 QNQRKVSNTASTTSHMTTTNSSNSSTT-----SVTTQQQKEQI---------------------- 427

Human   735 GGGSGTAGGGWSGITGFFTPRLIKKTLGLRAGKPTASDDT-SKPFPRSNSTSSMSS--------G 790
            ||.|.|....:           |||| |..:...|:|..| |....|..|..|..|        |
  Fly   428 GGSSSTTSKVY-----------IKKT-GSSSNSTTSSTTTASSSAGRKESFGSRDSLNDILSETG 480

Human   791 LP-----------EQDRMAMTLPRNC--------QRSKLQLERTVS--------TSSQPEENVDR 828
            ||           |...:.:|.|...        |||......|.|        |||...::::
  Fly   481 LPTGNVAAQRKSLENKNLDLTKPPGVGASVSIGQQRSSTSSATTSSATTVATGLTSSSVSKSME- 544

Human   829 ANDMLPKKSEESAAP-SRERPKAKLLPRGATALPL-RTPSGDLAITEKDPPGVGVAGVAAAPKGK 891
              :||.:|.:....| ..::|          ::|| :||:|          ||.:.|....  ||
  Fly   545 --NMLDEKVKSPPPPVLSKKP----------SVPLKKTPTG----------GVPMTGNLLG--GK 585

Human   892 EKNGGARL----------GMAG---------VPEDG----------------------------- 908
            :||...:|          |:|.         :||.|
  Fly   586 KKNTEGKLTTAVSHDLADGLAASKMLSGANQLPESGAAGNVVIRRAATIAVEDTDFDRVERASIL 650

Human   909 --------EQPGWPSPAKAAPVLPTTHNHKVPVLISPTLKHTPADVQLIGTDSQGNKFKLLSEHQ 965
                    :.|....|:.|..||..::|:.|.|..|          .:.|:...|:..:|..:..
  Fly   651 TDMRQGRVKAPKRRPPSAAINVLGESNNNSVYVNGS----------GMSGSGGAGSASELSEDGG 705

Human   966 VTSSGDKDRPRRVKPKCAPPPP--------PVMRLLQHPSIC---SDPTEEPTALTAGQSTSETQ 1019
            .......|.....:|:.|.|.|        |.|..|:...:.   :.|:.||...:..:.||:..
  Fly   706 AGGKTSDDNSTGEEPQLAKPKPREWEKKKAPWMEELKASQVTRKKTSPSVEPRGASVAERTSKLF 770

Human  1020 EGGKKAALGAVPISGKAGRPVMPPPQVPLPTSSISPAKMANGTAGTKV-----------ALRKTK 1073
            ...:..:..:..|:.|.        |....|||:.   :.|.|..:.|           |:....
  Fly   771 AAEQAVSSNSSSITTKV--------QSSAVTSSMF---VENSTTSSSVITSSSHTTTNDAIMSRS 824

Human  1074 QAAEKISADKISKEA------------------LLECADLLSSALTEPVPNSQLVDTGHQLLDYC 1120
            .:|.|:......:|.                  |::.::..||...|..|.|||  ..||  |..
  Fly   825 LSAAKVQTASSDEETRATRPNSLAIRNQRSVSPLVKSSNASSSQSQEEKPTSQL--NNHQ--DAS 885

Human  1121 SGYVDCIPQTRNKFAFREAVSKLELSLQEL--QVSSAAAGVPGTNPVLNNLLSCVQEI 1176
            |..|..:.|..:|  ....|...:.:::||  .:.|.|..|......|:....||.::
  Fly   886 SSRVAQLEQRVDK--LEGLVLNQQRTIEELVNALKSEAERVKILRSELDKYAQCVTQV 941

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ABL2	NP_009298.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..47
		CAP	2..106
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	60..80
		SH3_Abl	111..164	CDD:212784
		SH2_ABL	169..262	CDD:198189
		PTKc_Abl	281..543	CDD:270645	4/11 (36%)
		Pkinase_Tyr	288..539	CDD:285015	3/7 (43%)
		Kinase activation loop. /evidence=ECO:0000250	427..451
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	611..641		6/39 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	654..674		6/24 (25%)
		Nuclear localization signal. /evidence=ECO:0000255	658..660		0/1 (0%)
		F-actin-binding. /evidence=ECO:0000250	694..930		65/329 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	763..794		11/50 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	807..851		12/52 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	964..1024		13/70 (19%)
		F-actin-binding. /evidence=ECO:0000250	1020..1182		37/188 (20%)
		FABD	1063..1182	CDD:197885	29/145 (20%)
cindr	NP_001263129.1	SH3_CD2AP-like_1	6..60	CDD:212806
		SH3_CD2AP-like_2	97..149	CDD:212807
		SH3_CD2AP-like_3	258..310	CDD:212808	8/51 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910