DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ABL2 and Cad96Ca

DIOPT Version :9

Sequence 1:	NP_009298.1	Gene:	ABL2 / 27	HGNCID:	77	Length:	1182	Species:	Homo sapiens
Sequence 2:	NP_651349.1	Gene:	Cad96Ca / 43026	FlyBaseID:	FBgn0022800	Length:	773	Species:	Drosophila melanogaster

Alignment Length:	704	Identity:	185/704 - (26%)
Similarity:	268/704 - (38%)	Gaps:	229/704 - (32%)

- Green bases have known domain annotations that are detailed below.

Human    33 RRRDPAGRTTETGFNIFTQHDHFASCVEDGFE--GDKTGGSSPEALHRPYGCDVEP--QALNEAI 93
            |..||.|             |.....:|..|.  |.:...|.||.:  |:..|.|.  ..|||::
  Fly    80 RAEDPDG-------------DDLIFGIEPRFSLPGGENDASPPEKI--PFQIDRETGVVTLNESL 129

Human    94 RWSSKENLLGATESDPNLFVALYD--FVASGDNTLSITKGEKLRVLGYNQNGEWSEV-------- 148
            ...:.:|.|        :::.:.|  :.|..:..::|. ||:....||......|.|
  Fly   130 AGRAGQNFL--------IYITVTDGSYTAKNEVFINIL-GERENSSGYRPQTSISNVVHNISQFL 185

Human   149 ----------RSKNG------QGWVP--------------SNY---------------------- 161
                      ..:||      .||.|              :||
  Fly   186 PRFDQLPGVQSIRNGLPNSRPGGWYPPVPQNNIFGPPPFGNNYPPPPPNIPGVRGEQSGEEEQPD 250

Human   162 ---------------------ITPV---NSLEKHS-----------WYHGPVSRSAAEYLLSS-- 189
                                 :||:   ||....|           .:|...|.....:.|.|
  Fly   251 EEVTPTTPVRISSTTPKSRTKLTPITANNSTRVESAIPAETTTPSGGHHNNSSSPITIFSLKSGT 315

Human   190 -----LINGSFL-----------------------VRESE-----SSPGQLSISLRYEGR---VY 218
                 .:.|.|:                       .:|.|     |:..|||.:|..:.|   |.
  Fly   316 IPIVVTVGGFFVAIAVLLAYLCRRRLCAISRTLKKTKEKEELAKKSNQSQLSSTLTDDSRNSMVM 380

Human   219 HYRINTTADGKVYV---------TAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKP----- 269
            .......|....||         .|.|:.||         .|.:|.|::...|:|...:|
  Fly   381 QQWQGPVAFANRYVPWERDQQMGIATSQLST---------GVTNGGVSSPGVPSPGTGEPGSNLG 436

Human   270 ---------------TVYGVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWK---------KY 310
                           ..:......|:||..|..:...:.||.|.:|:    ||:         :.
  Fly   437 PGCLTGGAGSSGAPENAFAGEANCDRWEFPRYRLKFFNILGEGAFGQ----VWRCEATNINGNEG 497

Human   311 SLTVAVKTLKEDTMEVE--EFLKEAAVMKEIK-HPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDY 372
            ..|||||||||...||:  :.|.|..|||.:: |.|:|.|||.||.:.|.:::.||:..|.|..|
  Fly   498 ITTVAVKTLKESATEVDRKDLLSELEVMKSLEPHINVVHLLGCCTDKDPTFVILEYVNRGKLQTY 562

Human   373 LRECNREE-----------VTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVA 426
            ||....|.           :|:..|.....|::..|:||..:..|||||||||.|:.::|..|||
  Fly   563 LRSSRAERHYGNTHGKSNVLTSCDLTSFMYQVAKGMDYLTSRGIIHRDLAARNILITDDHTCKVA 627

Human   427 DFGLSR-LMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGID 490
            |||.:| ::|...|...:..|.||:|.|.|||..|.||:|||:|:||:|:|||.|.|.:|||||.
  Fly   628 DFGFARDVITSKIYERKSEGKLPIRWMATESLYDNIFSVKSDIWSFGILMWEIVTLGSTPYPGIS 692

Human   491 LSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFETMFH 544
            .:.|...:..|||:|:||.|..::|.:|..||...|.:||.|||..|..:.:.|
  Fly   693 AADVMRKVRDGYRLEKPEHCRRELYNIMYYCWSHDPQERPLFAEIIQMLDKLLH 746

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ABL2	NP_009298.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..47		4/13 (31%)
		CAP	2..106		19/76 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	60..80		6/21 (29%)
		SH3_Abl	111..164	CDD:212784	16/135 (12%)
		SH2_ABL	169..262	CDD:198189	26/150 (17%)
		PTKc_Abl	281..543	CDD:270645	115/285 (40%)
		Pkinase_Tyr	288..539	CDD:285015	112/274 (41%)
		Kinase activation loop. /evidence=ECO:0000250	427..451		9/24 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	611..641
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	654..674
		Nuclear localization signal. /evidence=ECO:0000255	658..660
		F-actin-binding. /evidence=ECO:0000250	694..930
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	763..794
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	807..851
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	964..1024
		F-actin-binding. /evidence=ECO:0000250	1020..1182
		FABD	1063..1182	CDD:197885
Cad96Ca	NP_651349.1	Cadherin_repeat	65..164	CDD:206637	24/107 (22%)
		STYKc	470..741	CDD:214568	112/274 (41%)
		PTKc	474..742	CDD:270623	112/271 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910