DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ABL2 and InR

DIOPT Version :9

Sequence 1:NP_009298.1 Gene:ABL2 / 27 HGNCID:77 Length:1182 Species:Homo sapiens
Sequence 2:NP_001138093.1 Gene:InR / 42549 FlyBaseID:FBgn0283499 Length:2144 Species:Drosophila melanogaster


Alignment Length:1199 Identity:269/1199 - (22%)
Similarity:410/1199 - (34%) Gaps:367/1199 - (30%)


- Green bases have known domain annotations that are detailed below.


Human    22 IRGSSAARPSGRRRDPA--GRTTETGFNIFTQH--------DHFASCVEDGFEGDKTGGSSPEAL 76
            |....|..||.||||.|  ....:...::..:|        |.|....::....|:...||.:..
  Fly  1072 IPNGGATNPSRRRRDVALEPELDDVEGSVLLRHVRSITDDTDAFFEKDDENTYKDEEDLSSNKQF 1136

Human    77 HRPYGCDVEP-------QALNEAIRW-----SSKENLLGATESDPNLFVALYDFVASGDNTLSIT 129
            :..:..::.|       :.|....|:     :.:|.:......|.:...:|   .:..|.....|
  Fly  1137 YEVFAKELPPNQTHFVFEKLRHFTRYAIFVVACREEIPSEKLRDTSFKKSL---CSDYDTVFQTT 1198

Human   130 KGEK-------LRVLGYNQNGEWSEVRSKNGQGWVPSNYITPVN------------SLEKHSWYH 175
            |.:|       |:|...:.|...|.||.:    |.|     ||:            .|:|.....
  Fly  1199 KRKKFADIVMDLKVDLEHANNTESPVRVR----WTP-----PVDPNGEIVTYEVAYKLQKPDQVE 1254

Human   176 GPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEG--------RVYHYRINTTAD-GKVY 231
            ......||::..::    .:|::.:|   |..|..:|...        .|.|.::..... .||:
  Fly  1255 EKKCIPAADFNQTA----GYLIKLNE---GLYSFRVRANSIAGYGDFTEVEHIKVEPPPSYAKVF 1312

Human   232 VTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCN--------KPTVYGVSPIHDKWEMERTDI 288
                  |..|...:........|.|..||......|        .|....:..|.|.||:.|.:|
  Fly  1313 ------FWLLGIGLAFLIVSLFGYVCYLHKRKVPSNDLHMNTEVNPFYASMQYIPDDWEVLRENI 1371

Human   289 TMKHKLGGGQYGEVYVGVWKKY-----SLTVAVKTLKEDTMEVE--EFLKEAAVMKEIKHPNLVQ 346
            .....||.|.:|.||.|:.|.:     ....|:||:.|:..:.|  .||.||:||||....::|:
  Fly  1372 IQLAPLGQGSFGMVYEGILKSFPPNGVDRECAIKTVNENATDRERTNFLSEASVMKEFDTYHVVR 1436

Human   347 LLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLY--------------------MAT 391
            |||||:...|..:|.|.|..|:|..|||....||....::.|                    ||.
  Fly  1437 LLGVCSRGQPALVVMELMKKGDLKSYLRAHRPEERDEAMMTYLNRIGVTGNVQPPTYGRIYQMAI 1501

Human   392 QISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSR-LMTGDTYTAHAGAKFPIKWTAPE 455
            :|:..|.||..|.|:|||||||||:|.::..||:.|||::| :...|.|........|::|..||
  Fly  1502 EIADGMAYLAAKKFVHRDLAARNCMVADDLTVKIGDFGMTRDIYETDYYRKGTKGLLPVRWMPPE 1566

Human   456 SLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRA 520
            ||....:|..|||::|||:|||:||....||.|:...||...:..|..||:||.||..:::||:.
  Fly  1567 SLRDGVYSSASDVFSFGVVLWEMATLAAQPYQGLSNEQVLRYVIDGGVMERPENCPDFLHKLMQR 1631

Human   521 CWKWSPADRPSFAE----------THQAFETMFHDSSISEEVAEELGRAASSSSVVPYLPRLPIL 575
            ||....:.||||.:          ..|..|..|:.|....:..|:..:..:.......:|     
  Fly  1632 CWHHRSSARPSFLDIIAYLEPQCPNSQFKEVSFYHSEAGLQHREKERKERNQLDAFAAVP----- 1691

Human   576 PSKTRTLKKQVENKENIEGAQ------DATENSA--------------------SSLAPGFIRGA 614
                  |.:.::::|..|.|.      |..:||:                    .||..|||   
  Fly  1692 ------LDQDLQDREQQEDATTPLRMGDYQQNSSLDQPPESPIAMVDDQGSHLPFSLPSGFI--- 1747

Human   615 QASSGSP-----------ALPRKQRDKSPSSLLEDAKETCFTRDRKGGFFSSFMKKRNAPTPPKR 668
              :|.:|           .:|..|.|.|.:.::.||  .....||....:....|....||....
  Fly  1748 --ASSTPDGQTVMATAFQNIPAAQGDISATYVVPDA--DALDGDRGYEIYDPSPKCAELPTSRSG 1808

Human   669 SSSFREMENQPH---KKYELTGNFSSVASLQHAD----GFSFTPAQQEANLVPPKCYGG------ 720
            |:...::..:.|   :|    |...::.|....|    |.|..|:...|.......:.|      
  Fly  1809 STGGGKLSGEQHLLPRK----GRQPTIMSSSMPDDVIGGSSLQPSTASAGSSNASSHTGRPSLKK 1869

Human   721 ----------SFAQRNLCNDDGGG-----------------------------------GGGSGT 740
                      :|..|:|.|....|                                   .||||:
  Fly  1870 TVADSVRNKANFINRHLFNHKRTGSNASHKSNASNAPSTSSNTNLTSHPVAMGNLGTIESGGSGS 1934

Human   741 AGGGWSGITGFFTPRLIKKTLGLRAGKPTASDDTSKPFPRSNSTSSMSSGLPEQDRMAMTLPRNC 805
            | |.::|...|:||                           ::|....||:...|.....|   .
  Fly  1935 A-GSYTGTPRFYTP---------------------------SATPGGGSGMAISDNPNYRL---L 1968

Human   806 QRSKLQLERTVSTSSQPEENVDRANDMLPKKSEESAAPSRERPKAKLLPRGATALPL-RTPSGDL 869
            ..|....:.|:.|:|.|..|.:..:                 |...|:......:|: .||    
  Fly  1969 DESIASEQATILTTSSPNPNYEMMH-----------------PPTSLVSTNPNYMPMNETP---- 2012

Human   870 AITEKDPPGVGVAGVAAA------PKGKEKNGGARLGMAGVPEDGEQ------------------ 910
                     |.:|||..:      |.....|  ||...:...||.||                  
  Fly  2013 ---------VQMAGVTISHNPNYQPMQAPLN--ARQSQSSSDEDNEQEEDDEDEDDDVDDEHVEH 2066

Human   911 ----------------PGWPSPAKAAPVLPTTHNHKVPVLISPTLKHTPADVQLIGTDSQGNKFK 959
                            |....|.::..|..|..        |||..::.     ||....||:..
  Fly  2067 IKMERMPLSRPRQRALPSKTQPPRSRSVSQTRK--------SPTNPNSG-----IGATGAGNRSN 2118

Human   960 LLSEHQVTSSGDKDRPRRVKPKCAPPPPP 988
            ||.|:.            ::|...|.|||
  Fly  2119 LLKENW------------LRPASTPRPPP 2135

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ABL2NP_009298.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..47 9/26 (35%)
CAP 2..106 19/105 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 60..80 3/19 (16%)
SH3_Abl 111..164 CDD:212784 13/59 (22%)
SH2_ABL 169..262 CDD:198189 18/101 (18%)
PTKc_Abl 281..543 CDD:270645 109/299 (36%)
Pkinase_Tyr 288..539 CDD:285015 105/288 (36%)
Kinase activation loop. /evidence=ECO:0000250 427..451 7/24 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 611..641 9/40 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 654..674 4/19 (21%)
Nuclear localization signal. /evidence=ECO:0000255 658..660 1/1 (100%)
F-actin-binding. /evidence=ECO:0000250 694..930 54/331 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 763..794 3/30 (10%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 807..851 7/43 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 964..1024 5/25 (20%)
F-actin-binding. /evidence=ECO:0000250 1020..1182
FABD 1063..1182 CDD:197885
InRNP_001138093.1 Recep_L_domain 356..465 CDD:279382
Furin-like 512..645 CDD:279142
FU 545..592 CDD:238021
Recep_L_domain 663..781 CDD:279382
FN3 1224..1302 CDD:238020 17/93 (18%)
PTKc_InsR_like 1364..1652 CDD:173625 107/287 (37%)
Pkinase_Tyr 1371..1650 CDD:285015 104/278 (37%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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