DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ABL2 and htl

DIOPT Version :9

Sequence 1:	NP_009298.1	Gene:	ABL2 / 27	HGNCID:	77	Length:	1182	Species:	Homo sapiens
Sequence 2:	NP_524394.2	Gene:	htl / 42160	FlyBaseID:	FBgn0010389	Length:	729	Species:	Drosophila melanogaster

Alignment Length:	595	Identity:	164/595 - (27%)
Similarity:	248/595 - (41%)	Gaps:	137/595 - (23%)

- Green bases have known domain annotations that are detailed below.

Human   100 NLLGATESDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEW-----SEVRSKNGQGWVPS 159
            |.||....|..:.|:  |.|   ::...:..|.....|..|..|..     |::.||....:||.
  Fly   178 NSLGCIRHDTQVIVS--DRV---NHKPILMTGPLNLTLVVNSTGSMHCKYLSDLTSKKAWIFVPC 237

Human   160 NYITPVNS------------------LEKHSWYHGPVSRSAAEYLLSSLINGSFLVRESES---- 202
            :.:|..::                  :|:..||....|.|..:      .|.:..:|...|
  Fly   238 HGMTNCSNNRSIIAEDKDQLDFVNVRMEQEGWYTCVESNSLGQ------SNSTAYLRVVRSLHVL 296

Human   203 SPGQLSISLRYEGRVYHYRINTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKC- 266
            ..|..|.||.....||.:    ...|.:::...:.|...|.....|..|....:.|:|....|.
  Fly   297 EAGVASGSLHSTSFVYIF----VFGGLIFIFMTTLFVFYAIRKMKHEKVLKQRIETVHQWTKKVI 357

Human   267 -----------------------------------NKPTVYG--VSPIHDKWEMERTDITMKHKL 294
                                               |:|..:.  ..|:...||:.|:.:.:...|
  Fly   358 IFKPEGGGDSSGSMDTMIMPVVRIQKQRTTVLQNGNEPAPFNEYEFPLDSNWELPRSHLVLGATL 422

Human   295 GGGQYGEVYVGVWKKYSLTVAVKTLKEDTM--EVEEFLKEAAVMKEI-KHPNLVQLLGVCTLEPP 356
            |.|.:|.|.:.  :..:..||||.:||...  ::...::|..|||.| :|.|::.|||.|:...|
  Fly   423 GEGAFGRVVMA--EVNNAIVAVKMVKEGHTDDDIASLVREMEVMKIIGRHINIINLLGCCSQNGP 485

Human   357 FYIVTEYMPYGNLLDYL-------RECNREE-----------VTAVVLLYMATQISSAMEYLEKK 403
            .|::.||.|:|||.|:|       |:.:|:.           :|...|:..|.||:..|:||..:
  Fly   486 LYVIVEYAPHGNLKDFLYKNRPFGRDQDRDSSQPPPSPPAHVITEKDLIKFAHQIARGMDYLASR 550

Human   404 NFIHRDLAARNCLVGENHVVKVADFGLSR-LMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSD 467
            ..|||||||||.||.:::|:|:|||||:| :.:.|.|..:...:.||||.|||||....:..|||
  Fly   551 RCIHRDLAARNVLVSDDYVLKIADFGLARDIQSTDYYRKNTNGRLPIKWMAPESLQEKFYDSKSD 615

Human   468 VWAFGVLLWEIATYGMSPYPGI-DLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPS 531
            ||::|:|||||.|||..|||.| ...::|..|..|.|||:|..|...:|.|||.||.::..|||.
  Fly   616 VWSYGILLWEIMTYGQQPYPTIMSAEELYTYLMSGQRMEKPAKCSMNIYILMRQCWHFNADDRPP 680

Human   532 FAETHQAFETMFHDSSISEEVAEELGRAASSSSVVPYLPRLPILPSKTRTLKKQVENKENIEGAQ 596
            |.|                              :|.|:.:|  |.:|...|...:.|.:......
  Fly   681 FTE------------------------------IVEYMDKL--LQTKEDYLDVDIANLDTPPSTS 713

Human   597 DATENSASSL 606
            |..|:...:|
  Fly   714 DEEEDETDNL 723

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ABL2	NP_009298.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..47
		CAP	2..106		3/5 (60%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	60..80
		SH3_Abl	111..164	CDD:212784	12/57 (21%)
		SH2_ABL	169..262	CDD:198189	21/96 (22%)
		PTKc_Abl	281..543	CDD:270645	112/284 (39%)
		Pkinase_Tyr	288..539	CDD:285015	109/273 (40%)
		Kinase activation loop. /evidence=ECO:0000250	427..451		9/24 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	611..641
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	654..674
		Nuclear localization signal. /evidence=ECO:0000255	658..660
		F-actin-binding. /evidence=ECO:0000250	694..930
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	763..794
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	807..851
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	964..1024
		F-actin-binding. /evidence=ECO:0000250	1020..1182
		FABD	1063..1182	CDD:197885
htl	NP_524394.2	Ig	112..191	CDD:299845	4/12 (33%)
		IG_like	113..191	CDD:214653	4/12 (33%)
		IG_like	205..289	CDD:214653	15/89 (17%)
		PKc_like	404..692	CDD:304357	116/321 (36%)
		STYKc	416..688	CDD:214568	110/303 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100013
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810