DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ABL2 and by

DIOPT Version :9

Sequence 1:	NP_009298.1	Gene:	ABL2 / 27	HGNCID:	77	Length:	1182	Species:	Homo sapiens
Sequence 2:	NP_001163569.1	Gene:	by / 41144	FlyBaseID:	FBgn0000244	Length:	720	Species:	Drosophila melanogaster

Alignment Length:	639	Identity:	125/639 - (19%)
Similarity:	197/639 - (30%)	Gaps:	233/639 - (36%)

- Green bases have known domain annotations that are detailed below.

Human   677 NQPHKKYEL--------TGNFSSVAS---LQHADGFSFTPAQQEANLVPPKCYG----------- 719
            |..:|.|.:        .||.|.:.:   :.:.:|:......:|.:|  |..||
  Fly    27 NNYYKNYNVNGNGQANGNGNLSGIGNGNGIGNGNGYGIPYHARENSL--PFSYGIAKTSTPLRKT 89

Human   720 ------GSF-------AQRNLCNDDGGGGGGSGTAGGGWSGITGFFTPRLIKKTLGLRAGKPTAS 771
                  .||       ...|:.::.....||:|......:.:|   :|.|::|||| .|..||:|
  Fly    90 PTPTRVDSFLDFDFGPTNTNVNSNSSSNNGGTGDMIKPPTRLT---SPLLVRKTLG-NAVSPTSS 150

Human   772 DDTSKPFPRSNSTSSMSSGLPEQDRMAMTLPRNCQRSKLQLERTVSTSSQPEENVDRANDMLPKK 836
            .:|:......:.|||.::..|.:|.....|..  :|.|:..|         ..|:||      :.
  Fly   151 TNTNTIANTYHYTSSSATPTPVRDNFEQLLRE--RREKVYNE---------YRNLDR------ES 198

Human   837 SEESAAPSRERPKAKLLPRGATALPLRTPSGDLAITEKDPPGVGVAGVAAAPKGKEKNGG--ARL 899
            |.|.|..:...|:.:..|.....:.|:..|.. .:..|.|...|        |..:.|..  ..|
  Fly   199 SGERARVAPAPPQRQYYPSDGYGIGLKNDSNG-TLYRKSPSSNG--------KSTKYNYDFEFNL 254

Human   900 GMAGV-PEDGEQPGWPSPAKAAPV------------------------------LPTTH------ 927
            .:..| ||       |:|.....:                              |.|||
  Fly   255 NLDDVRPE-------PTPYTTRNIHFEDLRLDQDVPDGVVNRRTMERNYHTINSLETTHKRQQLE 312

Human   928 -----------NHKVPVLISPTLKHTPADVQLIGTDSQGNKFKLLSEHQVTSSGDKDRPRRVKPK 981
                       ||     :..||..|..|               ||....||......|....|.
  Fly   313 PLEQLGAVYGQNH-----MEETLTRTRRD---------------LSASTSTSKSTSPLPAIGVPA 357

Human   982 CAPPPP---PVMRLLQHPS------ICSDPTEEPTALTAGQSTSETQEGGKKAALGAVPISGKAG 1037
            .||..|   ...:.:.:|:      :...||..|          ||.         |.|::
  Fly   358 IAPASPIYATSTKRVSNPNTNGQQQMTPSPTSRP----------ETP---------AFPVT---- 399

Human  1038 RPVMPPPQVPLPTSSISPAKMANGT-------------AGTKVALRKTKQAAEKISADKISKE-- 1087
                  |:.|...||.|.|.:|..|             .|...||:..:.:|:.:...:.|.:
  Fly   400 ------PRTPFGASSSSSASLAPTTQLPPESIYQTGPRRGVPPALQPLEVSADSVQFARSSSQFW 458

Human  1088 -----------ALLECAD----LLSSALT------------EPVPNSQLVDTGHQLLDYCSGYV- 1124
                       |||..|.    |:..:.|            :|.|.||.: ..|.|::...|.|
  Fly   459 YKPNLTREDAIALLASAQPGTFLVRDSTTYKDSYGLVVRVSQPPPGSQEL-VRHFLIEPTKGGVH 522

Human  1125 ------DCIPQTRNKFAFREAVSKLEL-SLQELQVSSAAAGVPGTNPVLNNLLS 1171
                  :.:..:.:...|..::|:|.| .|..|........|..|.|...:||:
  Fly   523 LKGCDDEPVFTSLSALVFEHSISQLALPCLLRLPDRDIVPPVRATTPAQQHLLA 576

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ABL2	NP_009298.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..47
		CAP	2..106
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	60..80
		SH3_Abl	111..164	CDD:212784
		SH2_ABL	169..262	CDD:198189
		PTKc_Abl	281..543	CDD:270645
		Pkinase_Tyr	288..539	CDD:285015
		Kinase activation loop. /evidence=ECO:0000250	427..451
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	611..641
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	654..674
		Nuclear localization signal. /evidence=ECO:0000255	658..660
		F-actin-binding. /evidence=ECO:0000250	694..930		59/312 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	763..794		9/30 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	807..851		10/43 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	964..1024		13/68 (19%)
		F-actin-binding. /evidence=ECO:0000250	1020..1182		40/202 (20%)
		FABD	1063..1182	CDD:197885	30/146 (21%)
by	NP_001163569.1	SH2_Tensin_like	454..559	CDD:198181	21/105 (20%)
by	NP_001163569.1	PTB_tensin	578..711	CDD:269924
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910