DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ABL2 and wnd

DIOPT Version :9

Sequence 1:	NP_009298.1	Gene:	ABL2 / 27	HGNCID:	77	Length:	1182	Species:	Homo sapiens
Sequence 2:	NP_649137.3	Gene:	wnd / 40143	FlyBaseID:	FBgn0036896	Length:	977	Species:	Drosophila melanogaster

Alignment Length:	909	Identity:	213/909 - (23%)
Similarity:	325/909 - (35%)	Gaps:	238/909 - (26%)

- Green bases have known domain annotations that are detailed below.

Human   266 CNKPTV-----YGV----SPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKE 321
            |.||.:     .||    |...:.|::....||....||.|..|.|:.|..|  :.|||||.:||
  Fly   130 CMKPVLSFIGKTGVIEVKSQRSEDWQIPFESITELEWLGSGAQGAVFSGRLK--NETVAVKKVKE 192

Human   322 DTMEVEEFLKEAAV--MKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAV 384
                    |||..:  ::::.|.|:::..||||..|.|.|:.|:.|||.|.:.|:|   |:|...
  Fly   193 --------LKETDIKHLRKLDHENIIKFKGVCTQSPVFCIIMEFCPYGPLQNILKE---EQVMLP 246

Human   385 V-LLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTG-DTYTAHAGAKF 447
            . |:..:.||:..|:||.....|||||.:.|.|:..|.|||::|||.||.... .|..:.||.
  Fly   247 SRLVSWSKQIALGMQYLHSHKIIHRDLKSPNILISTNEVVKISDFGTSREWNEISTKMSFAGT-- 309

Human   448 PIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQ-VYDLLEKGYRMEQPEGCP 511
             :.|.|||.:.....|.|.|:|::||:|||:.|..: ||..:|.|. ::.:.....::..|..||
  Fly   310 -VAWMAPEVIRNEPCSEKVDIWSYGVVLWEMLTCEI-PYKDVDSSAIIWGVGNNSLKLLVPSTCP 372

Human   512 PKVYELMRACWKWSPADRPSFAE--TH--------------QAFETMFHDSSISEEVAEELGRAA 560
            .....|::.|||..|.:||||.:  :|              |.|||   ..|..|||...|....
  Fly   373 EGFKLLVKLCWKSKPRNRPSFRQILSHLDIAGPELLRKTEKQYFET---QKSWKEEVRSHLKEIT 434

Human   561 SSSSVV-----------------------PYLPRLPILPSKTRTL-------KKQVENKENIEGA 595
            .:.:.:                       .|..:|    .||..|       ..|::.||. |.|
  Fly   435 QNGTNIHKYEQDLIKRRTAEWRHAQDIRMVYEDKL----QKTNQLFFELSECMSQLQEKEK-EIA 494

Human   596 QDATENSASSLAP-----GFIRGAQ----ASSGSPALPRKQR-----DKSPSS-----LLEDAKE 641
            :...:...|...|     ..||..|    ..:.:||..::|.     :.:|.|     |......
  Fly   495 ERERKLPGSGYKPNRRFGNTIRKMQHYRRRLNPAPAAIQQQSTTPDPETTPESPVKCMLYAQLDS 559

Human   642 TCFTRDRKGGFFSSFMKKRNAPTPPKRSSSFREMENQPHKKYELTGNFSSVASLQHADGFSFTPA 706
            .|..:........|  ....||.|.|....||...|       .:|:|.:..        .::|.
  Fly   560 NCQPKSYLANIIPS--SGLGAPMPNKNKKVFRHRRN-------ASGSFGAPP--------KYSPT 607

Human   707 QQEANLVPPKCYGGSFAQRNLCND--DGGGGGGSGTAGGGWSGITGFFTP-------------RL 756
            :.......|:.......:|....|  |......|.:|....|.......|             ::
  Fly   608 RDRRYQSEPENRKVQLVERQTQTDAMDVSETDISPSAEAPRSQPIDVPVPNHRQLPLQLQRVQKI 672

Human   757 IKKTLGLRAGKPTASDDTSKPFPRSNSTSSMSSGLPEQD-----------------RMAMTLPRN 804
            .:.....|:|..:::.....|...||..|..:|.|..||                 |:.||   .
  Fly   673 AQAQARARSGSTSSAAGAVNPACPSNGNSLSTSELTYQDACSSPDQLIDDVMNSNERLDMT---E 734

Human   805 CQRSKLQLER--------------TVSTSSQPEENVDRANDMLPKKSEESAAP--SRERPKAKLL 853
            |......|||              ::.:::....|.|..|.        .|:|  .||...:..|
  Fly   735 CCSDNENLERLGRKVIEFINENRLSIQSNTNSVSNADNGNG--------GASPLELRESGNSPCL 791

Human   854 PRGATALPLRT--PSGDLAITEKDPPGVGVAGVAAAPKGKEKNGGARLGMAGVPEDGEQPGW--- 913
            .|.::....|.  |.||      :|.|..:...         ||.:....:...|:||...:
  Fly   792 SRCSSTHSKRRKHPLGD------NPNGSSIGNA---------NGESHEQDSWSDEEGETTDYKYA 841

Human   914 ----------------PSPAKAAPVLPTTHNHKVPVLI-------------SPTLKHTP------ 943
                            |..:..||:......||..|:|             ||:.:|:.
  Fly   842 LRRRSIGRQPIARGMRPRRSYKAPLSQKIAIHKRNVVIVSDEEENTSEYSHSPSSQHSTLESNTD 906

Human   944 -ADVQLI-GTDSQGNKFKLLSEHQVTSSGDKDRPRRVKPKCAPPPPPVMRLLQHPSICSDPTEE 1005
             ||::.. .|.:..|.:....:....||.::...|..:.|...|..| |..::...|.|.||.|
  Fly   907 IADMKKTQATSTSSNSYSEPEDDSSDSSDEEQGNRPTEAKAEGPALP-MGAVRSSDIISIPTFE 969

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ABL2	NP_009298.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..47
		CAP	2..106
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	60..80
		SH3_Abl	111..164	CDD:212784
		SH2_ABL	169..262	CDD:198189
		PTKc_Abl	281..543	CDD:270645	98/282 (35%)
		Pkinase_Tyr	288..539	CDD:285015	94/271 (35%)
		Kinase activation loop. /evidence=ECO:0000250	427..451		8/24 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	611..641		9/43 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	654..674		6/19 (32%)
		Nuclear localization signal. /evidence=ECO:0000255	658..660		0/1 (0%)
		F-actin-binding. /evidence=ECO:0000250	694..930		49/304 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	763..794		8/30 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	807..851		10/59 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	964..1024		12/42 (29%)
		F-actin-binding. /evidence=ECO:0000250	1020..1182
		FABD	1063..1182	CDD:197885
wnd	NP_649137.3	STYKc	161..400	CDD:214568	92/255 (36%)
wnd	NP_649137.3	STKc_MAP3K12_13	167..403	CDD:270961	91/252 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910