Protein Alignment ABL2 and nwk

DIOPT Version :9

• Sequence 1: NP_009298.1
• Gene: ABL2 / 27
• HGNCID: 77
• Length: 1182
• Species: Homo sapiens
• Sequence 2: NP_001286994.1
• Gene: nwk / 39052
• FlyBaseID: FBgn0263456
• Length: 1075
• Species: Drosophila melanogaster
• Alignment Length: 740
• Identity: 146/740 - (19%)
• Similarity: 224/740 - (30%)
• Gaps: 283/740 - (38%)

Human    56 ASCVEDGFEGDKTGG-SSPEALHRPYGCDVEPQALNEAIRWSSKENLLGATESDPNLFVALYDFV 119
            |:...........|| ..|..::  :|...|....:|.|....||.:...|        |||.:.
  Fly   500 AAAASSSMMASSAGGWDDPTEVN--WGAGEEEDDKDEPIVPEPKEAIFKCT--------ALYSYT 554

Human   120 ASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNG-QGWVPSNYITPVNSLEKHSWYHG------- 176
            |...:.|:|.:.|:|.|:|......|...|:..| :|:||.||: .::.....|.::|
  Fly   555 AQNPDELTIVENEQLEVVGEGDGDGWLRARNYRGEEGYVPHNYL-DIDQETAGSAFNGTSGNQLR 618

Human   177 -PVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRV----------YHYRINTTADGKV 230
             .:|.|:.:|    .::......:|..||.|:|:.:..:.||          |.|  :.||:.::
  Fly   619 SQISFSSVDY----TVDNEDQTVDSMQSPDQVSVIMAPQKRVKSDVEWCIALYDY--DATAEDEL 677

Human   231 YVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDKWEMERTDITMKHKLG 295
            ......:...:.:..|   .|.||.                         ||.|.
  Fly   678 TFEEGDKIKIITKTAH---GVDDGW-------------------------WEGEL---------- 704

Human   296 GGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIV 360
            .|::|..       .||.|      |:..|:.|.|.|                |.....||....
  Fly   705 DGKFGNF-------PSLVV------EECDEMGEPLSE----------------GGDESPPPTAAP 740

Human   361 TEYMPYGNLL--DYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVV 423
            |..:|....|  :|..|...|
  Fly   741 TFALPPAPALPPEYAHELELE-------------------------------------------- 761

Human   424 KVADFGLSRLMTGDTYTAHAGAKF-PIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYP 487
                  |:..|.|...||...:.: |....||        ||...     ||:.|         |
  Fly   762 ------LTEDMFGSQDTADEDSGYIPNGAAAP--------SIPPP-----VLIQE---------P 798

Human   488 GIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFETMFHDSSISEEV 552
            |::    .||.:.|   :.|...||                 |..|:.        ..|:.....
  Fly   799 GME----DDLSDDG---QPPPSLPP-----------------PQLAKA--------GGSAPGSGS 831

Human   553 AEELGRAASSSSVVPYLPRLPILPSKTRTLKKQVENKENIEGAQDA----TENSASSLAPGFIRG 613
            ..|.|.||..::.:.......|:.:.|..::         :||..:    .|:.|..:.|
  Fly   832 KVEKGAAAGGANTLNLGMAQIIVTAATPMVE---------DGADKSFPPVGESDAQPVEP----- 882

Human   614 AQASSGSPALPRKQRDKSPSSLLEDAKETCFTRDRKGGFFSSFMKKRNAPTPPKRSSSFREM--- 675
              .|...||...|:.|.:|..|.:.|.:            |:..|:.||...|..|.:..|.
  Fly   883 --VSKEQPAEVAKKPDIAPKPLAKVAPQ------------SAPAKEGNAGVRPVVSITLTEYPSC 933

Human   676 ---ENQPHKKYELTGNFSSVASLQHA-------------DGFSFTPAQQEANLVPPKCYGGSFAQ 724
               :.|...:...:.:.:.|..||.|             ||..| .|..|||      :..:|
  Fly   934 DAEDQQSFSEGTDSASVADVPVLQDAEDPFNEKAKGESGDGSGF-EANFEAN------FDANF-- 989

Human   725 RNLCNDD-----GGGGGGSGTAGGG 744
                 ||     ||||||.|  |||
  Fly   990 -----DDAFAGIGGGGGGGG--GGG 1007

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ABL2	NP_009298.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..47
		CAP	2..106		10/50 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	60..80		3/20 (15%)
		SH3_Abl	111..164	CDD:212784	18/53 (34%)
		SH2_ABL	169..262	CDD:198189	20/110 (18%)
		PTKc_Abl	281..543	CDD:270645	45/264 (17%)
		Pkinase_Tyr	288..539	CDD:285015	42/253 (17%)
		Kinase activation loop. /evidence=ECO:0000250	427..451		6/24 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	611..641		8/29 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	654..674		6/19 (32%)
		Nuclear localization signal. /evidence=ECO:0000255	658..660		1/1 (100%)
		F-actin-binding. /evidence=ECO:0000250	694..930		23/69 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	763..794
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	807..851
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	964..1024
		F-actin-binding. /evidence=ECO:0000250	1020..1182
		FABD	1063..1182	CDD:197885
nwk	NP_001286994.1	BAR	16..281	CDD:353336
		SH3_FCHSD_1	545..600	CDD:212695	19/63 (30%)
		SH3	663..718	CDD:354299	16/107 (15%)
		PRK12323	<725..956	CDD:237057	63/378 (17%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910