DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ABL2 and PVRAP

DIOPT Version :9

Sequence 1:	NP_009298.1	Gene:	ABL2 / 27	HGNCID:	77	Length:	1182	Species:	Homo sapiens
Sequence 2:	NP_729124.1	Gene:	PVRAP / 38677	FlyBaseID:	FBgn0052406	Length:	474	Species:	Drosophila melanogaster

Alignment Length:	218	Identity:	57/218 - (26%)
Similarity:	86/218 - (39%)	Gaps:	26/218 - (11%)

- Green bases have known domain annotations that are detailed below.

Human    65 GDKTGGSSPEALHRPYGCDVEPQALNEAIRWSSK-ENLLGATESDPNLFVALYDFVASGDNTLSI 128
            ||.|..|:|        .|::|...|..|...|. ::..|.:.......:.:.|.|...||....
  Fly   228 GDMTPLSAP--------LDIQPVYSNGYINEDSYIDSKFGDSCRQSLTAIPMLDNVNLNDNNEFN 284

Human   129 TKGEKLR-VLGYNQNGEWSEVRSKNGQGWVPSNYITPVNS------------LEKHSWYHGPVSR 180
            .|...|| ....|.:.:....|.:..||.|.....:..|:            |:...||...:||
  Fly   285 LKKRYLRETSSANSSPKIFANRLRMNQGAVGQRCSSLANAFGNVGSDEEDLELKDACWYQAGISR 349

Human   181 SAAEYLLSSLINGSFLVRESESSPGQLSISLRYEG----RVYHYRINTTADGKVYVTAESRFSTL 241
            ..|..:|.|...|:||||:|.|.||..:::||...    ::.:|.|..:..|.........||:|
  Fly   350 DIAVEVLQSKSPGAFLVRKSSSKPGCYALTLRVPSPPGPKIANYIILRSPRGYKIKGFRKEFSSL 414

Human   242 AELVHHHSTVADGLVTTLHYPAP 264
            ..|:.|||.:.:.|...|..|.|
  Fly   415 KALITHHSVMPELLPVPLAMPRP 437

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ABL2	NP_009298.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..47
		CAP	2..106		11/41 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	60..80		5/14 (36%)
		SH3_Abl	111..164	CDD:212784	12/53 (23%)
		SH2_ABL	169..262	CDD:198189	30/96 (31%)
		PTKc_Abl	281..543	CDD:270645
		Pkinase_Tyr	288..539	CDD:285015
		Kinase activation loop. /evidence=ECO:0000250	427..451
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	611..641
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	654..674
		Nuclear localization signal. /evidence=ECO:0000255	658..660
		F-actin-binding. /evidence=ECO:0000250	694..930
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	763..794
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	807..851
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	964..1024
		F-actin-binding. /evidence=ECO:0000250	1020..1182
		FABD	1063..1182	CDD:197885
PVRAP	NP_729124.1	SH2	342..435	CDD:301589	30/92 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910