DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ABL2 and Ack

DIOPT Version :9

Sequence 1:NP_009298.1 Gene:ABL2 / 27 HGNCID:77 Length:1182 Species:Homo sapiens
Sequence 2:NP_647859.1 Gene:Ack / 38489 FlyBaseID:FBgn0028484 Length:1073 Species:Drosophila melanogaster


Alignment Length:1066 Identity:246/1066 - (23%)
Similarity:381/1066 - (35%) Gaps:317/1066 - (29%)


- Green bases have known domain annotations that are detailed below.


Human   277 IHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYS----LTVAVKTLKEDTME----VEEFLKEA 333
            ||:|      ||||..|||.|.:|.|..|.|....    :.||||.||.|.:.    :::|.:|.
  Fly   118 IHEK------DITMGLKLGDGSFGVVRRGEWSASPAGKVIPVAVKVLKSDNLTQPGIIDDFFREV 176

Human   334 AVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLR-ECNREEVTAVVLLYMATQISSAM 397
            ..|..:.|.|||:|.|| .|..|..::||....|:|||.|| :|....:|  ::...:.||.:.|
  Fly   177 QAMHALDHANLVRLYGV-VLSQPMMMITELAERGSLLDTLRKQCRHTSLT--IIWNWSVQIVTGM 238

Human   398 EYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLM--TGDTYTAHAGAKFPIKWTAPESLAYN 460
            .|||:|.|:|||||.||.|:...:.:|:.||||.|.:  ..|.|......|.|..|.|||||.:.
  Fly   239 AYLEQKRFLHRDLACRNVLLAAGNKIKIGDFGLMRALPQEDDCYVMSEHKKVPFPWCAPESLRFR 303

Human   461 TFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEK-GYRMEQPEGCPPKVYELMRACWKW 524
            .||..||.|.|||.|||:.::|..|:.|::.||:...::: |.|:.||:.|||.||.:|..||..
  Fly   304 QFSHASDTWMFGVTLWEMFSFGEDPWVGLNGSQILRKIDREGERLHQPDACPPDVYAMMLQCWDK 368

Human   525 SPADRPSFAETHQAFETM----------FHDS-SISEEVAEELGRAASSSSVVPYLPRLPILPSK 578
            :||:||:||...:...:|          .|:| .:..|..:.:       :::.....|.::..:
  Fly   369 TPAERPTFAALKEYLASMSPPVMRASRSHHESKGLQIEPGDTI-------AIIDGRHELKLIKGQ 426

Human   579 T-RT-----LKKQVENKENIEGAQDATENSA----SSLAP-GFIRGAQASSGSPALPRKQRDKSP 632
            . ||     ..:.:..:..:..|.|....|:    ||.:| ||..|..|:..:.           
  Fly   427 NQRTFDIGIFPRNLLEQRKVGAAGDVVMRSSVGNGSSSSPFGFCWGGAAAMANG----------- 480

Human   633 SSLLEDAKETCFTRDRKGGFFSSFMKKRNAPTPPKRSSSFREMENQPHKKYELTGNFSSVASLQ- 696
                :|.:..|                             ..|.||||.|..     .|.:|.| 
  Fly   481 ----DDRQRKC-----------------------------ASMTNQPHAKER-----KSTSSKQF 507

Human   697 --------HADGFSFTPAQQEANLV-------PPKCYGGSFAQRNLCND---------DGGGGGG 737
                    .|.|.....|.:...:|       ||:     |.|..:..|         :.|.||.
  Fly   508 AYNKLVNDSATGLQRRNAVKHKGVVVGPQRPPPPQ-----FQQEGILIDISPDMRPIAEAGTGGA 567

Human   738 SGT------------------------AGGGWSGITGF------------FTPRLIKKTLGLRAG 766
            .|.                        ||...||....            |.|           .
  Fly   568 KGAGDSSSLQADSSFCILDAPIDVPTYAGSSGSGDLNVSPTYYNEQPQFDFDP-----------A 621

Human   767 KPTASDDTSKPFP------RSNSTSSMSSGLPEQDRMAMTLPRNCQRSKLQLERTVSTSSQPEEN 825
            |.|||....:|.|      .||:...:......|.::|..:..........:|.||:..|...::
  Fly   622 KMTASPGRLQPPPYQMPPTYSNTMEFVQKRDLHQQQLATPVRERDPFDTTNVETTVALYSNFNQS 686

Human   826 VDRANDMLP--------------KKSEESAAPSRERPKAKL------LPR-GATAL----PLRTP 865
            ::.|:...|              .||.:...|:.|....:|      |.| .||.:    |:..|
  Fly   687 LEAASPPAPIYNSPSVRKSLFGGSKSNKENIPALESAAMQLNLSNLTLERHDATCIQPVEPVPAP 751

Human   866 SGDLAITEKDPPGVGVAGVAAAPKGKEKNGGARL---------------------GMAGVPEDGE 909
            .||..:.:|       :.:|...|....||..|.                     .:..: ::|.
  Fly   752 PGDGVLLDK-------SFIAELEKDMYSNGQNRAQEEYQRNSTQMYASKDMVYKQNLTPL-KNGA 808

Human   910 QPG-----WPSPAKAAPVLPTTHNHKVPVLISPTLKHTPADV---QLIGTDS------------- 953
            .||     ..||:..|.  |..:|.:.....:.|.:.....:   |:..|.|             
  Fly   809 APGSVHSNHSSPSSTAS--PKQNNVEAAAAAAATTQSVVNRIWYEQVASTQSEYYAQPPTEQAEE 871

Human   954 ---QGNKFKLLSEHQVTSSGDKDRPRRVKPKCAPPPPPVMRLLQHPSICSDPT--EEPTALTAGQ 1013
               |.::.:...:.::..|......|.|.||             :.:..|..:  :...|.|||.
  Fly   872 QIYQNHRHQQQQQQELNHSFVAISNRVVAPK-------------NNAYSSTASLYDAVAASTAGS 923

Human  1014 STSETQEGGKKAALGAVPISGKAGRPVMPPPQVPLPTSSISPAKMANGTAGTKVALRKTKQAAEK 1078
            :.......|..|.|..........||..|.|..|.|.|:                    :|...:
  Fly   924 TYYGQVPNGSGAVLYDEVTQDDYLRPTRPAPLAPPPLSA--------------------QQIQRR 968

Human  1079 ISADKISKEALLECADLLSSALTEPVPNSQLVDTGHQ-------LLDYCSGYVDCIPQTRNKFAF 1136
            :...::.::..|:.|..|.:    |||:    |.|.:       :.:..|..|:  ...||  |.
  Fly   969 MEKMRLQQQQQLDGAHQLYA----PVPS----DYGREQEKLQQLMQELGSSAVE--QDVRN--AL 1021

Human  1137 REAVSKLELSLQELQVSS-AAAGVPG 1161
            |.|...:.|:.:..::.. |..||.|
  Fly  1022 RAASGDVGLATRHYKIDQLARLGVAG 1047

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ABL2NP_009298.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..47
CAP 2..106
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 60..80
SH3_Abl 111..164 CDD:212784
SH2_ABL 169..262 CDD:198189
PTKc_Abl 281..543 CDD:270645 108/283 (38%)
Pkinase_Tyr 288..539 CDD:285015 106/262 (40%)
Kinase activation loop. /evidence=ECO:0000250 427..451 9/25 (36%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 611..641 3/29 (10%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 654..674 0/19 (0%)
Nuclear localization signal. /evidence=ECO:0000255 658..660 0/1 (0%)
F-actin-binding. /evidence=ECO:0000250 694..930 64/353 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 763..794 8/36 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 807..851 10/57 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 964..1024 11/61 (18%)
F-actin-binding. /evidence=ECO:0000250 1020..1182 31/150 (21%)
FABD 1063..1182 CDD:197885 21/107 (20%)
AckNP_647859.1 SAM_TNK-like 14..75 CDD:188938
PTKc_Ack_like 128..385 CDD:270636 103/259 (40%)
UBA_TNK1 1031..1070 CDD:270513 4/17 (24%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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