DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ABL2 and Dlish

DIOPT Version :9

Sequence 1:	NP_009298.1	Gene:	ABL2 / 27	HGNCID:	77	Length:	1182	Species:	Homo sapiens
Sequence 2:	NP_611251.2	Gene:	Dlish / 37014	FlyBaseID:	FBgn0034264	Length:	355	Species:	Drosophila melanogaster

Alignment Length:	209	Identity:	54/209 - (25%)
Similarity:	89/209 - (42%)	Gaps:	34/209 - (16%)

- Green bases have known domain annotations that are detailed below.

Human    82 CDVEPQALNEAIRWSSKENLLGATESDP------NLFVALYDFVASGDNTLSITKGEKLRVLGYN 140
            ||   :.||.....|.:..||...|..|      ...:.||.|:|..:|.||:.:||.:.||. .
  Fly   155 CD---ETLNPGSANSIENTLLVEPECTPFVKEPSGRCIVLYTFIARDENDLSVERGEFVTVLN-R 215

Human   141 QNGEWSEVRSKNGQ-GWVPSNYITPVNS---LEKHSWYHGPVSRSAAEYLLSSLINGSFLVRESE 201
            ::.:|..:...:|| |:||:::|.|.:|   |::..     .:.:|.|.:|.....|....::.:
  Fly   216 EDPDWFWIMRSDGQEGFVPASFIYPADSVRVLQQQK-----ATLNAMETILQQGQQGQQSQQQQQ 275

Human   202 SSPGQLSISLRYEG----RVYHYRINTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYP 262
            ...|..:..|||.|    .:|.|:.....|  :|::........|:|.:.   ..||.:...
  Fly   276 PQLGLGTDDLRYHGTELVMLYDYKAQAPDD--LYLSVRRGDWIYADLTNQ---TVDGWLWAY--- 332

Human   263 APKCNKPTVYGVSP 276
            |||..|   ||..|
  Fly   333 APKTRK---YGFIP 343

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ABL2	NP_009298.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..47
		CAP	2..106		7/23 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	60..80
		SH3_Abl	111..164	CDD:212784	18/53 (34%)
		SH2_ABL	169..262	CDD:198189	17/96 (18%)
		PTKc_Abl	281..543	CDD:270645
		Pkinase_Tyr	288..539	CDD:285015
		Kinase activation loop. /evidence=ECO:0000250	427..451
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	611..641
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	654..674
		Nuclear localization signal. /evidence=ECO:0000255	658..660
		F-actin-binding. /evidence=ECO:0000250	694..930
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	763..794
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	807..851
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	964..1024
		F-actin-binding. /evidence=ECO:0000250	1020..1182
		FABD	1063..1182	CDD:197885
Dlish	NP_611251.2	SH3	61..111	CDD:212690
		SH3	184..238	CDD:214620	17/54 (31%)
		SH3	293..346	CDD:212690	15/62 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910