DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ABL2 and Nrk

DIOPT Version :9

Sequence 1:	NP_009298.1	Gene:	ABL2 / 27	HGNCID:	77	Length:	1182	Species:	Homo sapiens
Sequence 2:	NP_477255.1	Gene:	Nrk / 36445	FlyBaseID:	FBgn0020391	Length:	724	Species:	Drosophila melanogaster

Alignment Length:	537	Identity:	158/537 - (29%)
Similarity:	235/537 - (43%)	Gaps:	104/537 - (19%)

- Green bases have known domain annotations that are detailed below.

Human    52 HDHFAS--CVEDGFEGD----KTGGSSPEALHRPYGCDVEPQALNEAIRWSSKENLLGATESDPN 110
            |.||..  ......||:    ..||..|    .|: |    ..::|::||...:..:.....|||
  Fly   249 HKHFQPPLVFHQLLEGENYCRNAGGEEP----HPW-C----YTVDESVRWQHCDIPMCPDYVDPN 304

Human   111 ------------LFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQGWVPSNYIT 163
                        .|.....|:.:|...::|.....:.:|.|
  Fly   305 AVDLNTPIKMEKFFTPSMIFLLAGIGFVAIVTLHLMILLVY------------------------ 345

Human   164 PVNSLEKHSWYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTADG 228
               .|.||..|..|...:.||..:|        :|......|.|:.|            ..|..|
  Fly   346 ---KLSKHKDYSQPAGAATAECSVS--------MRGGGDCGGNLNTS------------RETLGG 387

Human   229 KVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDKWEMERTDITMKHK 293
            .......:::.|:......||... .|.|..:....|..||...     .:|.|..|.||.....
  Fly   388 NGNTNTLAKWGTIRSTATIHSNCV-ALTTVTNVSDAKGTKPNAR-----LEKLEYPRGDIVYVRS 446

Human   294 LGGGQYGEVYVG-----VWKKYSLTVAVKTLKEDT---MEVEEFLKEAAVMKEIKHPNLVQLLGV 350
            ||.|.:|.|:..     |..:..|.||||.||:|.   |:: :|.:||.::.|..|||:|:||||
  Fly   447 LGQGAFGRVFQARAPGLVPDQEDLLVAVKMLKDDASDQMQM-DFEREACLLAEFDHPNIVRLLGV 510

Human   351 CTLEPPFYIVTEYMPYGNLLDYLREC-----------NREEVTAVVLLYMATQISSAMEYLEKKN 404
            |.|..|..::.|||..|:|.::||.|           :|.::..:.||.||..|::.|.||.::.
  Fly   511 CALGRPMCLLFEYMAPGDLSEFLRACSPYATHQAPTQDRLQLNELHLLQMAANIAAGMLYLSERK 575

Human   405 FIHRDLAARNCLVGENHVVKVADFGLS-RLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDV 468
            |:|||||.||||:.|:..||:|||||| ::...|.|........||:|...||:.||.||::|||
  Fly   576 FVHRDLATRNCLINEHMAVKIADFGLSHKIYLQDYYKGDENDFIPIRWMPLESILYNKFSLESDV 640

Human   469 WAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFA 533
            ||:|:.|||:.::.:.||.|:...:|...:::|..:..|:..|..||.|||.||...|::||.||
  Fly   641 WAYGICLWEVFSFALQPYFGLTHEEVIKYIKEGNVLGCPDNTPLSVYALMRRCWNRKPSERPGFA 705

Human   534 ETHQAFETMFHDSSISE 550
            |.:...:   |..:.||
  Fly   706 EINHCIQ---HSIAESE 719

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ABL2	NP_009298.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..47
		CAP	2..106		13/59 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	60..80		5/23 (22%)
		SH3_Abl	111..164	CDD:212784	6/52 (12%)
		SH2_ABL	169..262	CDD:198189	18/92 (20%)
		PTKc_Abl	281..543	CDD:270645	110/281 (39%)
		Pkinase_Tyr	288..539	CDD:285015	107/270 (40%)
		Kinase activation loop. /evidence=ECO:0000250	427..451		9/24 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	611..641
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	654..674
		Nuclear localization signal. /evidence=ECO:0000255	658..660
		F-actin-binding. /evidence=ECO:0000250	694..930
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	763..794
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	807..851
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	964..1024
		F-actin-binding. /evidence=ECO:0000250	1020..1182
		FABD	1063..1182	CDD:197885
Nrk	NP_477255.1	CRD_FZ	67..212	CDD:295308
		KR	217..299	CDD:214527	13/58 (22%)
		PTKc_Musk	435..713	CDD:133181	110/281 (39%)
		Pkinase_Tyr	441..707	CDD:285015	106/266 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910