Protein Alignment ABL2 and Src42A

DIOPT Version :9

• Sequence 1: NP_009298.1
• Gene: ABL2 / 27
• HGNCID: 77
• Length: 1182
• Species: Homo sapiens
• Sequence 2: NP_610191.2
• Gene: Src42A / 35524
• FlyBaseID: FBgn0264959
• Length: 1597
• Species: Drosophila melanogaster
• Alignment Length: 434
• Identity: 188/434 - (43%)
• Similarity: 259/434 - (59%)
• Gaps: 29/434 - (6%)

Human   122 GDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQGWVPSNYITPVNSLEKHSWYHGPVSRSAAE-- 184
            |..:|:..|..|.|.|.....||:                      |.:.|||...:.|..||
  Fly  1181 GKTSLTTAKKGKSRRLSEFTRGEF----------------------LNEKSWYFRKIKRIEAEKK 1223

Human   185 YLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTADGKVYVTAESRFSTLAELVHHHS 249
            .||....:|:||:|:|||.....|:|:|....|.||||....:|..::...:.|.||.|||.|:|
  Fly  1224 LLLPENEHGAFLIRDSESRHNDYSLSVRDGDTVKHYRIRQLDEGGFFIARRTTFRTLQELVEHYS 1288

Human   250 TVADGLVTTLHYPAPKCNKPTVYGVS-PIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLT 313
            ..:|||...|..|..:..||...|:| ...|:||::||.:....|||.||:|:|:.|:|.. :..
  Fly  1289 KDSDGLCVNLCKPCVQIEKPVTEGLSHRTRDQWEIDRTSLKFVRKLGSGQFGDVWEGLWNN-TTP 1352

Human   314 VAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLREC-- 376
            ||:||||..||:.::||.||.:||:::|..|:||..|||:|.|.||:||.|.:|:||:||:..
  Fly  1353 VAIKTLKSGTMDPKDFLAEAQIMKKLRHTKLIQLYAVCTVEEPIYIITELMKHGSLLEYLQAIAG 1417

Human   377 NREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTA 441
            ....:....|:.||.||::.|.|||.:|:|||||||||.|||:.::||:|||||:||:..|.|.|
  Fly  1418 KGRSLKMQTLIDMAAQIAAGMAYLESQNYIHRDLAARNVLVGDGNIVKIADFGLARLIKEDEYEA 1482

Human   442 HAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQ 506
            ..||:|||||||||:..|:.||||||||:||:||.|:.|||..||||:..::|...:|.||||.|
  Fly  1483 RVGARFPIKWTAPEAANYSKFSIKSDVWSFGILLTELVTYGRIPYPGMTNAEVLTQVEHGYRMPQ 1547

Human   507 PEGCPPKVYELMRACWKWSPADRPSFAETHQAFETMFHDSSISE 550
            |..|.|::||:|..||...|..||:| ||.|.....|:.|..|:
  Fly  1548 PPNCEPRLYEIMLECWHKDPMRRPTF-ETLQWKLEDFYTSDQSD 1590

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ABL2	NP_009298.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..47
		CAP	2..106
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	60..80
		SH3_Abl	111..164	CDD:212784	8/41 (20%)
		SH2_ABL	169..262	CDD:198189	36/94 (38%)
		PTKc_Abl	281..543	CDD:270645	134/263 (51%)
		Pkinase_Tyr	288..539	CDD:285015	130/252 (52%)
		Kinase activation loop. /evidence=ECO:0000250	427..451		14/23 (61%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	611..641
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	654..674
		Nuclear localization signal. /evidence=ECO:0000255	658..660
		F-actin-binding. /evidence=ECO:0000250	694..930
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	763..794
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	807..851
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	964..1024
		F-actin-binding. /evidence=ECO:0000250	1020..1182
		FABD	1063..1182	CDD:197885
Src42A	NP_610191.2	SH2_Src_Src42	1210..1301	CDD:198233	35/90 (39%)
		PTKc_Frk_like	1319..1587	CDD:270653	136/269 (51%)
		Pkinase_Tyr	1328..1580	CDD:285015	130/253 (51%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910