DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ABL2 and dock

DIOPT Version :9

Sequence 1:	NP_009298.1	Gene:	ABL2 / 27	HGNCID:	77	Length:	1182	Species:	Homo sapiens
Sequence 2:	NP_001259845.1	Gene:	dock / 33262	FlyBaseID:	FBgn0010583	Length:	548	Species:	Drosophila melanogaster

Alignment Length:	327	Identity:	74/327 - (22%)
Similarity:	132/327 - (40%)	Gaps:	87/327 - (26%)

- Green bases have known domain annotations that are detailed below.

Human    10 EAPGLQQ---PQPRGIRGSSAARPSGRRRDPAGRTTETGFNIFTQHDHFASCVEDGFEGDKTGGS 71
            |:|.:.:   |.|....|::..:.:.:.:.|...:...|..|......     .||:...::|.|
  Fly   238 ESPTMSRRLPPDPAEAIGTAVVKYNYQAQQPDELSLTKGTRILILEKS-----NDGWWRGQSGNS 297

Human    72 SP--EALHRPYGCDVEPQALNEAIRWSSKENLLGATESDPNLFVALYDFVASGDNTLSITKGEKL 134
            ..  .:.:....||.:    .|...::..||:|       ::.||||.|.::.|..||..||::|
  Fly   298 VGWFPSNYTTEDCDND----GEIHTYAMAENVL-------DIVVALYSFTSNNDQELSFEKGDRL 351

Human   135 RVLGY-NQNGEWSEVRSKNGQ-GWVPSNYITPVN------------------------------- 166
            .::.. ..:.:|.:.|:..|| |.||.||:..:|
  Fly   352 EIVDRPASDPDWYKARNNQGQVGLVPRNYLQELNDYLATPYRNASASAGNGNGGGSNGGAGGGGG 416

Human   167 --SLEKH-----------------------SWYHGPVSRSAAEYLLSSL-INGSFLVRESESSPG 205
              |:|:.                       |||:|.::||..:.:|:.. .:|.||:|:||::.|
  Fly   417 NDSMERRNEGNKPAAQSSGQPIERPNLAGKSWYYGAITRSQCDTVLNGHGHDGDFLIRDSETNMG 481

Human   206 QLSISLRYEGRVYHYRINTTADGKVYVTAESRFSTLAELVHHHS-----TVADGLVTTLHYPAPK 265
            ..|:||:..||..|:|::  .:..:|...:.:|.:|.:||.|:.     |...|....|....||
  Fly   482 DYSVSLKAPGRNKHFRVH--VEQNMYCIGQRKFHSLDQLVDHYQRAPIYTNKQGEKLYLVRSLPK 544

Human   266 CN 267
            .|
  Fly   545 AN 546

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ABL2	NP_009298.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..47		7/39 (18%)
		CAP	2..106		18/100 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	60..80		4/21 (19%)
		SH3_Abl	111..164	CDD:212784	20/54 (37%)
		SH2_ABL	169..262	CDD:198189	31/121 (26%)
		PTKc_Abl	281..543	CDD:270645
		Pkinase_Tyr	288..539	CDD:285015
		Kinase activation loop. /evidence=ECO:0000250	427..451
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	611..641
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	654..674
		Nuclear localization signal. /evidence=ECO:0000255	658..660
		F-actin-binding. /evidence=ECO:0000250	694..930
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	763..794
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	807..851
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	964..1024
		F-actin-binding. /evidence=ECO:0000250	1020..1182
		FABD	1063..1182	CDD:197885
dock	NP_001259845.1	SH3_Nck_1	154..204	CDD:212699
		SH3_Nck_2	256..308	CDD:212700	7/56 (13%)
		SH3_Nck_3	328..383	CDD:212701	20/54 (37%)
		SH2_Nck_family	446..538	CDD:198196	29/93 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910