DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ABL2 and Socs16D

DIOPT Version :9

Sequence 1:	NP_009298.1	Gene:	ABL2 / 27	HGNCID:	77	Length:	1182	Species:	Homo sapiens
Sequence 2:	NP_001259662.1	Gene:	Socs16D / 32760	FlyBaseID:	FBgn0030869	Length:	1021	Species:	Drosophila melanogaster

Alignment Length:	230	Identity:	52/230 - (22%)
Similarity:	87/230 - (37%)	Gaps:	70/230 - (30%)

- Green bases have known domain annotations that are detailed below.

Human   161 YITPVNSLEKHSWYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRI--- 222
            :.:.:..::.:.||.||:|..|||.:|||..:|||:||:|.......|:|.:....|.|.||
  Fly   838 FTSSIEKVKDYGWYWGPLSSEAAEKVLSSEPDGSFIVRDSSDDHYIFSLSFKLNNCVRHVRIEQD 902

Human   223 -NTTADGKVYVTAESRFSTLAELVH---HHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDKWEM 283
             .|.:.|..   |:.:..|:.|.:.   .||. :...:..||.             .|.|....:
  Fly   903 QGTFSFGSY---AKFKSQTITEFIEKAVEHSR-SGRYLFFLHR-------------RPEHGPMRV 950

Human   284 ERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLL 348
            :.|:...:.|                     .|::|        :.:....::|.:...:|:|
  Fly   951 QLTNPVSRFK---------------------HVQSL--------QHMCRFVILKAVIRKDLIQ-- 984

Human   349 GVCTLEPPFYIVTEYMPYGNLLDYL--RECNREEV 381
               ||..|          ..|||||  :.|..|:|
  Fly   985 ---TLPLP----------RRLLDYLNYKHCYSEQV 1006

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ABL2	NP_009298.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..47
		CAP	2..106
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	60..80
		SH3_Abl	111..164	CDD:212784	0/2 (0%)
		SH2_ABL	169..262	CDD:198189	32/99 (32%)
		PTKc_Abl	281..543	CDD:270645	18/103 (17%)
		Pkinase_Tyr	288..539	CDD:285015	17/96 (18%)
		Kinase activation loop. /evidence=ECO:0000250	427..451
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	611..641
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	654..674
		Nuclear localization signal. /evidence=ECO:0000255	658..660
		F-actin-binding. /evidence=ECO:0000250	694..930
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	763..794
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	807..851
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	964..1024
		F-actin-binding. /evidence=ECO:0000250	1020..1182
		FABD	1063..1182	CDD:197885
Socs16D	NP_001259662.1	SH2_SOCS7	839..937	CDD:198251	30/101 (30%)
Socs16D	NP_001259662.1	SOCS_SOCS7	960..1009	CDD:239710	17/91 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910