DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ABL2 and spri

DIOPT Version :9

Sequence 1:	NP_009298.1	Gene:	ABL2 / 27	HGNCID:	77	Length:	1182	Species:	Homo sapiens
Sequence 2:	NP_001259418.1	Gene:	spri / 31987	FlyBaseID:	FBgn0085443	Length:	2043	Species:	Drosophila melanogaster

Alignment Length:	849	Identity:	171/849 - (20%)
Similarity:	256/849 - (30%)	Gaps:	315/849 - (37%)

- Green bases have known domain annotations that are detailed below.

Human   544 HDSSISEEVAEELGRAASSSSVVPYLPRLPILPSKTRTLKKQVENKENIEGAQDATENSASSLAP 608
            |.||.:..|:|    :.|.||...|            :|::|::|..|.......|.:|.:.|..
  Fly   425 HSSSSTSSVSE----STSCSSSADY------------SLREQLKNFANRNSEGGGTIDSTARLIK 473

Human   609 GF---IRGAQASSGSPALPRKQRDKSPSSLLEDAKETCFTRDRKGGFFSSFMKKRNA-PTP---- 665
            |.   :......|.:|||        ..|||...:.....|..:...|....|.|.: |.|
  Fly   474 GMSLPVGDQSVQSVAPAL--------CDSLLSPQEVPLGRRYAEVAQFKGHPKARTSEPIPSGVA 530

Human   666 -PKRSSSFREMENQPHKKYELTGNFSSVASLQHADGFSFTPAQQEANLVPPKCYGGSFAQRNLCN 729
             |....|......:.|     |||.:::.:  :.:|.....:||:|.|....   ...||.||.|
  Fly   531 TPSSLDSASVDGGKSH-----TGNNNNINN--NHNGQQSQKSQQQAGLAAKL---NVLAQSNLNN 585

Human   730 DDGGGGGGSGTAGGGWSGIT----------------------------------GFF-------T 753
            ::.....||.|.....:|:.                                  |.|       .
  Fly   586 NNTTNQPGSMTPASNRTGLDSNQNQKQNLNADSRRSSSVDPDADADDVVDAAHGGAFEDDMQALL 650

Human   754 PR---------------LIKKTLG--LRAGKPTASDDTSKPF---------PRSNSTSSMSSGLP 792
            |:               |:..:.|  |..|:.::.||..:|.         .|.:|.:|....|.
  Fly   651 PKCSRRSRDELSQSRTSLVSSSEGGILAEGETSSEDDEEEPVEAEDEGEESSRDSSDNSPPCDLG 715

Human   793 EQDRMAMTLPR----NCQRS--------KLQLERTVSTSSQP-----------------EENVDR 828
            ..:|:.:|.|.    ..|||        |.:....|..||||                 |..:.:
  Fly   716 LMERLLVTHPMWFLPGIQRSGAVHLLQGKEEGTFIVRGSSQPNTMAVSVRLPQDTGPYIEHYLIQ 780

Human   829 AND-------------MLPKKSEESAAPSRERPKAKLLPR------------------------- 855
            ::|             .:|......|....|.|...:|||
  Fly   781 SHDNVLSLESSRFTFGSIPSLIAHYAQCCDELPVQLMLPRVLREANNRKKLSSLALLGQEFWSYV 845

Human   856 GATAL-----PLRTPSGD---------LAITE---------------KDPPGVGVAGVAAAPKG- 890
            .:.||     |...||.|         |::||               |.||    .|....|.|
  Fly   846 SSPALLGPLTPSVAPSKDQQLLDAKSPLSLTETSGLGTATFFSDTVSKPPP----TGAPPLPGGG 906

Human   891 --KEKNGGARLG---MAGVPED-------------GEQPGWPSPAKAAPVLPT-----THNHKVP 932
              .....|..||   .||.|.|             |:.....||.....|:.|     ...|.:|
  Fly   907 LFSPTGSGQLLGFFSQAGTPSDTTNSSLSSFTTSGGQHMQLLSPNSVDSVILTMSPVDNPGHYLP 971

Human   933 VLI-SPTLKHTPADVQLIGTDSQGNKFKLLSEHQVTSSGDKDRPRRVKP----KCAPPPPPVMRL 992
            ... :|.....|:.|     |.|.:.||:.   |.....|:.||:|.||    ...||.||:...
  Fly   972 GSTGAPMAPLCPSVV-----DQQLSTFKVA---QTAPEVDQVRPQRPKPPNTLNLKPPAPPLRWS 1028

Human   993 LQH-------------------------------PSI--------------CSDPTEEPTALTAG 1012
            ..|                               |::              .|:|.   .||..|
  Fly  1029 KPHSPDQNGSANGNFTVTTTVTFSMENGGGGGSGPTVGNGNGKFVEVTTPAASNPF---NALLNG 1090

Human  1013 Q-STSET------QEGGKKAALGAVPISGKAGRPVMPPPQVPLPTSSISPAKMANGTAGTKVALR 1070
            | ||.:|      .||..|..|.:...|....|  .|||...|.||.::|...:.|::.:....|
  Fly  1091 QASTFQTFAKRLSPEGECKDTLSSQGSSSNDSR--WPPPARKLLTSPMTPLTPSGGSSSSGGKSR 1153

Human  1071 KT---KQAAEKISADKISKEALLECADLLSSALT--------EPVPNSQLVDTGHQLLDYCSGYV 1124
            |:   |::.....:|.:....:..||..||..::        :|...:.|:.:....||...|.:
  Fly  1154 KSRAGKESQHYKESDILESPPMQYCASALSDKISDYEDVWSHDPSDRASLLTSFRPALDTVGGVM 1218

Human  1125 DCIP 1128
            :..|
  Fly  1219 NRRP 1222

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ABL2	NP_009298.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..47
		CAP	2..106
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	60..80
		SH3_Abl	111..164	CDD:212784
		SH2_ABL	169..262	CDD:198189
		PTKc_Abl	281..543	CDD:270645
		Pkinase_Tyr	288..539	CDD:285015
		Kinase activation loop. /evidence=ECO:0000250	427..451
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	611..641		7/29 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	654..674		6/25 (24%)
		Nuclear localization signal. /evidence=ECO:0000255	658..660		1/1 (100%)
		F-actin-binding. /evidence=ECO:0000250	694..930		76/422 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	763..794		9/39 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	807..851		14/81 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	964..1024		24/115 (21%)
		F-actin-binding. /evidence=ECO:0000250	1020..1182		28/120 (23%)
		FABD	1063..1182	CDD:197885	14/77 (18%)
spri	NP_001259418.1	SH2	716..813	CDD:301589	17/96 (18%)
		VPS9	1821..1922	CDD:280383
		UBQ	1946..2026	CDD:294102
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910