DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ABL2 and Takl1

DIOPT Version :9

Sequence 1:	NP_009298.1	Gene:	ABL2 / 27	HGNCID:	77	Length:	1182	Species:	Homo sapiens
Sequence 2:	NP_732554.1	Gene:	Takl1 / 318725	FlyBaseID:	FBgn0046689	Length:	393	Species:	Drosophila melanogaster

Alignment Length:	368	Identity:	89/368 - (24%)
Similarity:	167/368 - (45%)	Gaps:	51/368 - (13%)

- Green bases have known domain annotations that are detailed below.

Human   282 EMERTDITMKHK-LGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLV 345
            :::..::.:..| ||.|..|.|....::...:.|.:....|:|:: :...:|...:.||.|.|::
  Fly     4 QVDFAEVKLSEKFLGAGSGGAVRKATFQNQEIAVKIFDFLEETIK-KNAEREITHLSEIDHENVI 67

Human   346 QLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEK--KNFIHR 408
            :::|..:.....|::.||:..|:|.:||...::.|.|....:..|.|.:.|:.||..  :..:||
  Fly    68 RVIGRASNGKKDYLLMEYLEEGSLHNYLYGDDKWEYTVEQAVRWALQCAKALAYLHSLDRPIVHR 132

Human   409 DLAARNCLVGENHV-VKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFG 472
            |:..:|.|:...|. :|:.||||:..|:.:. |...|.   :::.|||::.:..::.|.||::||
  Fly   133 DIKPQNMLLYNQHEDLKICDFGLATDMSNNK-TDMQGT---LRYMAPEAIKHLKYTAKCDVYSFG 193

Human   473 VLLWEIATYGMSPYPGID--LSQ--VYDLLEKGYRMEQP---EGCPPKVYELMRACWKWSPADRP 530
            ::|||:.|..: ||..::  .||  :...:..|.::...   ..||..:.:||..|...:|..||
  Fly   194 IMLWELMTRQL-PYSHLENPNSQYAIMKAISSGEKLPMEAVRSDCPEGIKQLMECCMDINPEKRP 257

Human   531 SFAETHQAFETMFHDSSISEEVAEELGRAASSSSVVPY------------------LPRL----P 573
            |..|. :.|....::|...|:..:.|..  .:.:||.|                  ||.:    |
  Fly   258 SMKEI-EKFLGEQYESGTDEDFIKPLDE--DTVAVVTYHVDSSGSRIMRVDFWRHQLPSIRMTFP 319

Human   574 ILPSKTRTLKKQV---------ENKENIEGAQDATENSASSLA 607
            |:..:...|.|.|         :....:..|:..||...|..|
  Fly   320 IVKREAERLGKTVVREMAKAAADGDREVRRAEKDTERETSRAA 362

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ABL2	NP_009298.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..47
		CAP	2..106
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	60..80
		SH3_Abl	111..164	CDD:212784
		SH2_ABL	169..262	CDD:198189
		PTKc_Abl	281..543	CDD:270645	71/271 (26%)
		Pkinase_Tyr	288..539	CDD:285015	70/261 (27%)
		Kinase activation loop. /evidence=ECO:0000250	427..451		7/23 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	611..641
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	654..674
		Nuclear localization signal. /evidence=ECO:0000255	658..660
		F-actin-binding. /evidence=ECO:0000250	694..930
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	763..794
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	807..851
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	964..1024
		F-actin-binding. /evidence=ECO:0000250	1020..1182
		FABD	1063..1182	CDD:197885
Takl1	NP_732554.1	S_TKc	15..262	CDD:214567	69/252 (27%)
Takl1	NP_732554.1	STKc_TAK1	17..274	CDD:270960	71/263 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910