DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ABL2 and Wsck

DIOPT Version :9

Sequence 1:	NP_009298.1	Gene:	ABL2 / 27	HGNCID:	77	Length:	1182	Species:	Homo sapiens
Sequence 2:	NP_733018.1	Gene:	Wsck / 318600	FlyBaseID:	FBgn0046685	Length:	791	Species:	Drosophila melanogaster

Alignment Length:	626	Identity:	132/626 - (21%)
Similarity:	224/626 - (35%)	Gaps:	133/626 - (21%)

- Green bases have known domain annotations that are detailed below.

Human    40 RTTETGFNIFTQHDHF-------ASCVEDGFEGDKTGGSSPEA---LHRPYGCDVEPQALNEAIR 94
            ::|||.|.:...|...       |.|.:......:.|.:|.||   :..|.....:|:.|:...|
  Fly   199 QSTETQFELTDLHPATLYNISVRAMCKDAQVGQSECGQASIEATTEVGLPSPVPAQPKILSRTDR 263

Human    95 WSSKENLLGATESDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQGWVPS 159
            ..:.|  |....:|......|...|...||.||.....:|.       |.|.:.:    |..||
  Fly   264 TVTIE--LSPIRNDNGPLSKLLVIVEYVDNALSQPFDAQLL-------GSWQQAQ----QDGVP- 314

Human   160 NYITPVNSLEKHSWYHGPVSRSAAEYLL-SSLINGSFLVRESESSPGQLSISL----RYEG---- 215
            .||..  .|:    |..|.......::: .....|.|..:..:.....:.|||    ..||
  Fly   315 YYIAA--ELD----YDRPEDNRTRRFVVGDGKRYGRFTNKPLDQPDAHVHISLGLVSTLEGVTKT 373

Human   216 ---RVYHYRINTTADGKVYVTAESRFSTLAEL----VHHHSTVADGLVTTLHYPAPKCNKPTVYG 273
               |..|.:..|:.|...|.|.|...|::..|    |...|.:...|:...:.....|....:.|
  Fly   374 MYSRGTHDQHVTSLDDFSYATFEKGQSSVVALAVTCVIFGSCLLLSLIAYFYLRYKTCRGRRLTG 438

Human   274 ----------------------------VSPIHDKWEMER------------TDITMKHKLGGGQ 298
                                        .||.:.|.::::            ..:.:...:|.|:
  Fly   439 GNTHEMTLQTPIIERENNGYLVEDDPLPHSPENFKQQLQQLVEGYERIPRNALRLNVNDVIGDGR 503

Human   299 YGEVYVGVWKKYSLTVAVKTLKED-TMEV-----------EEFLKEAAVMKEIK-HPNLVQLLGV 350
            :||:..|       .|:......| |:.|           .:.|:|...:.::| ..:|:...||
  Fly   504 FGEIITG-------KVSTNDFARDCTLHVLCLDDLNGTTQAQLLRELRQLSQLKRQEHLLDFYGV 561

Human   351 CTLEPPFYIVTEYMPYG---NLLDYLRECNREEVTAV---VLLYMATQISSAMEYLEKKNFIHRD 409
            ......||::.|.....   .|::.........:|::   ::|....:::|||.||.....:||.
  Fly   562 SASPDWFYLIFEQQRMSLKRKLVESRLMAPSPRLTSLSEQLVLQWIYELASAMNYLSSCQVVHRQ 626

Human   410 LAARNCLVGENHVVKVADFG-LSRLMTGDTYTAHAGAKFPIKWTAPESLAY-NTFSIKSDVWAFG 472
            |.:.:..|..:..:|::.|| |..:........|.      :|.|||.|.: :..|.:||||:..
  Fly   627 LCSHSVFVTSDFKLKLSVFGPLPYMNIARQQPDHN------RWLAPEVLRHQHHHSTRSDVWSLA 685

Human   473 VLLWEIATYGMSPYPGIDLS--QVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAE- 534
            .:.||....|.:||.....|  |:.:.:....|..||......:|:|:..||:..|::|.|..:
  Fly   686 CVAWECCALGGTPYANAVASNQQLLEAIRAAVRPAQPAYVYGDLYQLLLNCWQLEPSERSSCEDV 750

Human   535 ---THQAFETMFHDSSISEEVAEELGRAASSSSVVPYLPRL 572
               ..|...:..|..|. :.||..|      .::.||||:|
  Fly   751 AFGVRQLMTSPRHALSF-DRVAGGL------DTLPPYLPQL 784

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ABL2	NP_009298.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..47		3/6 (50%)
		CAP	2..106		17/75 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	60..80		4/22 (18%)
		SH3_Abl	111..164	CDD:212784	14/52 (27%)
		SH2_ABL	169..262	CDD:198189	21/108 (19%)
		PTKc_Abl	281..543	CDD:270645	63/300 (21%)
		Pkinase_Tyr	288..539	CDD:285015	63/277 (23%)
		Kinase activation loop. /evidence=ECO:0000250	427..451		4/24 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	611..641
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	654..674
		Nuclear localization signal. /evidence=ECO:0000255	658..660
		F-actin-binding. /evidence=ECO:0000250	694..930
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	763..794
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	807..851
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	964..1024
		F-actin-binding. /evidence=ECO:0000250	1020..1182
		FABD	1063..1182	CDD:197885
Wsck	NP_733018.1	WSC	42..115	CDD:280068
		fn3	130..222	CDD:278470	5/22 (23%)
		TyrKc	493..746	CDD:197581	61/265 (23%)
		PTKc	497..750	CDD:270623	62/265 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910