DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ABL2 and shd1

DIOPT Version :10

Sequence 1:NP_009298.1 Gene:ABL2 / 27 HGNCID:77 Length:1182 Species:Homo sapiens
Sequence 2:NP_594213.1 Gene:shd1 / 2542338 PomBaseID:SPAC16E8.01 Length:1420 Species:Schizosaccharomyces pombe


Alignment Length:1168 Identity:201/1168 - (17%)
Similarity:329/1168 - (28%) Gaps:466/1168 - (39%)


- Green bases have known domain annotations that are detailed below.


Human     8 VGEAPGLQQPQPRGIRGSSAARPSGRRRDPAGRTTETGFNIFTQHDHFASCVED--GFEGDKTGG 70
            :|:..|  ..:..|:|..:||..|...:.|:....           |..:...|  |..|.:||.
pombe   433 LGDVAG--SARAAGLREIAAASGSPMPKLPSDSAL-----------HRLNAASDAAGVNGGRTGD 484

Human    71 SSPEALHRPYGCDVEPQALNEAIRWSSKENLLGATESDPNLFVALYDFVASGDNTLSITKGEKLR 135
            .....:   || |...:|.:...:.||....:|         ..||||:|...:.|::....::.
pombe   485 YEMSTV---YG-DRSARAEDHKPKDSSAGQKMG---------TVLYDFIAEAADELTVKANMRVV 536

Human   136 VLGYNQNGEWSEVRSKNGQGWVPSNYITPVNSLEKHSWYHGPVSRSAAEYLLSSLINGSFLVRES 200
            ::....:.:|.:......:|.||||:|.|....:..|    |.|.|.:.       .||.|.|.:
pombe   537 IVNDTASSDWWKCSVDGKEGVVPSNFIKPDTEGDAKS----PPSSSKSG-------QGSSLSRRA 590

Human   201 ESSPGQLSISLRYEGRVYHYRINTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPK 265
            .          ::|.:  |.|     |.|.....||:..:     |..|..|             
pombe   591 S----------KHESK--HKR-----DSKHEARPESKHES-----HRESKSA------------- 620

Human   266 CNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFL 330
                            |.::.|                                |:|..|..:..
pombe   621 ----------------EKDKKD--------------------------------KKDKKEDSKRS 637

Human   331 KEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISS 395
            :..:|.|    |:..:|.........|.:..|::.|.:...:|.:.|..:::..         |:
pombe   638 RSHSVSK----PDSSKLRTWTDRTGAFKVEAEFLGYSDDKIHLHKTNGVKISVP---------SA 689

Human   396 AMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYN 460
            .|.|                          .|.....||||                   ...|:
pombe   690 KMSY--------------------------KDLDYVELMTG-------------------KKVYS 709

Human   461 TFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYD-------LLEKGYRM-----EQPEGCPPK 513
            ....|.|            |...|...|...|:.:|       ..::.:|.     |:.||.||:
pombe   710 RTERKKD------------TQKQSHDHGHSHSKSHDREKEKEKKKDREHRKHRETEEEDEGPPPQ 762

Human   514 ---------------------VYELMRACWKWSPADRPSFAETHQAFETMFH---DSSISEEVAE 554
                                 .|::::        :||..  ::..|:....   |.::......
pombe   763 PARPESTRPALAPPSSSHSNDKYDVIQ--------ERPKI--SYDWFDFFLRCGVDFTVCNRYTH 817

Human   555 ELGRAASSSSVVPYLPRLPILPSKTRTLKKQ----VENKENIEGAQDATENSASSLAP------- 608
            .........:.:|.|.     |...|||..:    :....::......:...||::.|       
pombe   818 NFNNEHLDEACIPSLN-----PDTLRTLGLKEGDIIRVMNHVNELNGVSTKPASAITPETKSTVN 877

Human   609 GFIRGAQASSGSPALPRKQRDKSPSSLLEDAKETCFTRDRKGGFFSSFMKKRNAPTPPKRSSSFR 673
            ..:.|.:|.:...|:|.    ..|:.:.|                         |.||...:. .
pombe   878 QIMSGGEALAAPVAVPA----PIPAPVAE-------------------------PAPPAAPAK-E 912

Human   674 EMENQPHKKYELTGNFSSVASLQHADGFSFTPAQQEANLVPPKCYGGSFAQRNLCNDDGGGGGGS 738
            .:|..|.                       .||.:..:..|.|           .:||       
pombe   913 VVEKAPS-----------------------PPATRPKSTTPQK-----------FDDD------- 936

Human   739 GTAGGGWSGITGFFTPRLIKKTLGLRAGKPT------ASDDTSKPFPRSNSTSSMSSGLPEQDRM 797
                 .|                   |.||.      ||..|.:|...:.|.:.|:.....:...
pombe   937 -----AW-------------------ANKPVTEPPVRASSVTVEPARVTESMNKMNISEEAKKPE 977

Human   798 AMTLPRNCQRSKLQLERTVSTSSQPEENVDRANDMLPKKSEESAAPSRERPKAKLLPRGATALPL 862
            |.:.||...                          :|:..|:..||..::...|.:   ...:|.
pombe   978 APSRPRTAP--------------------------IPEPEEQKKAPVEKKDAEKSV---QAPIPA 1013

Human   863 RTPSGDLAITEKDPPGVGVAGVAAAPKGKEKNGGARLGMAGVPEDGE---QP-GWPSPAKAAPVL 923
            : |:|::.|..         ....||:          .||..|....   || |:..|..|.|:.
pombe  1014 Q-PTGNITIQN---------AYFTAPQ----------PMAADPFQSPLYVQPTGFQPPPSALPIQ 1058

Human   924 PTTHNHKVPVLISPTLKHTPADVQLIGTDSQGNKFKLLSEH------QVTS-----SGDKDRPRR 977
            ||.:...:||   ....:.|..||..|          |..|      |||.     :|...:...
pombe  1059 PTGYMQPIPV---QATGYQPLMVQPTG----------LQPHMTGVMPQVTGVMPQMTGVVPQMTG 1110

Human   978 VKPKC---------APPPPPV--------MRLLQHPSICSDPT----------EEPTALTAGQST 1015
            |.|:.         |.|..||        |: .|...|.|.||          .:||.|.. |:|
pombe  1111 VMPQMTGVQVQKTGAMPQQPVNYGYQVAGMQ-PQATGIISQPTGIRAQATGIMTQPTGLHT-QAT 1173

Human  1016 SETQEGG-KKAALGAVPISGKAGRPVMPPPQVPLPTSSISPAKMANGTAGTKVALRKTKQAAE 1077
            ...|..| :..|.|.:|.:....:|....|||    :.|.|..|......|.|.::||...|:
pombe  1174 GMMQPTGMQPQATGIMPQATGMMQPTGMQPQV----TGIMPQSMPMQPQMTGVQVQKTGMVAQ 1232

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ABL2NP_009298.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..47 8/38 (21%)
CAP 2..106 21/99 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 60..80 5/21 (24%)
SH3_Abl 111..164 CDD:212784 13/52 (25%)
SH2_ABL 169..262 CDD:198189 18/92 (20%)
PTKc_Abl 281..543 CDD:270645 40/294 (14%)
Kinase activation loop. /evidence=ECO:0000250 427..451 5/23 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 611..641 6/29 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 654..674 3/19 (16%)
Nuclear localization signal. /evidence=ECO:0000255 658..660 0/1 (0%)
F-actin-binding. /evidence=ECO:0000250 694..930 41/245 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 763..794 9/36 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 807..851 4/43 (9%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 964..1024 24/98 (24%)
F-actin-binding. /evidence=ECO:0000250 1020..1182 16/59 (27%)
FABD 1063..1182 CDD:197885 5/15 (33%)
shd1NP_594213.1 SH3_Sla1p_1 9..75 CDD:212707
SH3_Sla1p_2 84..134 CDD:212708
SH3_Sla1p_3 511..565 CDD:212709 14/62 (23%)
SHD1 641..706 CDD:427630 17/122 (14%)
SAM_SLA1_fungal 796..857 CDD:188931 8/65 (12%)
PRK10263 <918..>1068 CDD:236669 42/263 (16%)
Med15 1004..>1407 CDD:312941 64/271 (24%)
DUF1720 1044..1117 CDD:369766 22/85 (26%)
DUF1720 1140..1221 CDD:369766 23/86 (27%)
Blue background indicates that the domain is not in the aligned region.

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